In Vitro Antimicrobial, Antibiofilm and Cytotoxic Activities of the Extracts of Arum Italicum Miller Leaves

Hacıoğlu, Mayram

doi:10.31925/farmacia.2021.5.3

Cited by 1 publication

(1 citation statement)

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“…Araceae family is represented in Turkey by 32 taxa, 22 species, 5 subspecies and 12 varieties. There are approximately ten Arum species (Araceae) seen in the Turkish flora (1,2). These species are known as 'yılan yastığı', 'domuz lahanası', 'nivik' etc (3).…”

Section: Introductionmentioning

confidence: 99%

The Cytotoxicity and the Antimicrobial Activities of Arum italicum Miller

Ulusoylu¹,

GÜRBÜZ²

2022

jrp

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In this study, the cytotoxicity potential and antibacterial and antifungal activities of two different extracts of fresh leaves of Arum italicum Miller were investigated. The saponin extract and the alkaloid extract were investigated by Brine Shrimp (Artemia salina L.) lethality bioassay method for evaluation of cytotoxic effect. Umbelliferone was used as standard, and both of the extracts showed cytotoxic effect by the Brine Shrimp (Artemia salina L.) lethality bioassay method. According to the LC50 results, saponin extract was found to be the most active extract, and classifiable as moderate to highly toxic (LC50 237.1437 mg/mL -1 ). Although, the alkaloid extract was showed cytotoxic activity lower than Umbelliferone, LC50 750.1920 mg/mL -1 value was classifiable as mildly cytotoxic. Antibacterial and antifungal activities were tested by the agar well diffusion and tube dilution methods. 6 bacteria and 6 yeasts were used in the methods Meropenem and Fluconazole were the standards of the methods. The saponin extract was found to be effective against Staphylococcus epidermidis and Sthaphylococcus aureus compared with Meropenem. Both of the extracts were not found to be effective against fluconazole as antifungal activity point of view. According to the all studied activity results the saponin contents of the fresh leaves of the plant emphasizing the antimicrobial activity. And, both of the extracts have cytotoxic activity potential.

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Section: Introductionmentioning

confidence: 99%