In vitro antioxidant activity and in vivo anti-fatigue effect of loach (Misgurnus anguillicaudatus) peptides prepared by papain digestion

You, Lijun; Zhao, Ming; Regenstein, Joe M.; Ren, Jiaoyan

doi:10.1016/j.foodchem.2010.06.007

Cited by 260 publications

(217 citation statements)

References 28 publications

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“…Our results are in agreement with those of You et al (2011) which showed that peptides from loach (Misgurnus anguillicaudatus) prepared by papain digestion reduce oxidative stress in vivo by increasing the SOD, CAT and GPx activities. Another study reported that the supplementation of the sardinelle muscle protein hydrolysates produced by enzymatic hydrolysis with cholesterol-enriched diet reduces oxidative stress in vivo and increases the SOD, CAT and GPx activities (Ben Khaled et al 2012).…”

Section: Antioxidant Enzyme Activities In the Liver And Kidneyssupporting

confidence: 93%

Beneficial effects of fermented sardinelle protein hydrolysates on hypercaloric diet induced hyperglycemia, oxidative stress and deterioration of kidney function in wistar rats

et al. 2017

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This study investigated the potential effects of fermented sardinelle protein hydrolysates (FSPHs) obtained by two proteolytic bacteria, Bacillus subtilis A26 (FSPH-A26) and Bacillus amyloliquefaciens An6 (FSPHAn6), on hypercaloric diet (HCD) induced hyperglycemia and oxidative stress in rats. Effects of FSPHs on blood glucose level, glucose tolerance, a-amylase activity and hepatic glycogen content were investigated, as well as their effect on the oxidative stress state. Biochemical findings revealed that, while undigested sardinelle proteins did not exhibit hypoglycemic activity, oral administration of FSPHs to HCD-fed rats reduced significantly a-amylase activity as well as glycemia and hepatic glycogen levels. Further, the treatment with FSPHs improved the redox status by decreasing the levels of lipid peroxidation products and increasing the activities of the antioxidant enzymes (superoxide dismutase, glutathione peroxidase and catalase) and the level of glutathione in the liver and kidneys, as compared to those of HCD-fed rats. FSPHs were also found to exert significant protective effects on liver and kidney functions, evidenced by a marked decrease in alkaline phosphatase activity and a modulation of creatinine and uric acid contents. These results indicated the beneficial effect of FSPHs on the prevention from hyperglycemia and oxidative stress.

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Section: Antioxidant Enzyme Activities In the Liver And Kidneyssupporting

confidence: 93%

Beneficial effects of fermented sardinelle protein hydrolysates on hypercaloric diet induced hyperglycemia, oxidative stress and deterioration of kidney function in wistar rats

et al. 2017

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“…Further cleavage of peptides in two-step hydrolysis process by papain led to an enhanced reducing ability, plausibly due to the increases in the exposure of some amino acids, such as leucine, lysine, methionine or isoleucine at terminal of released peptides. You et al (2011) reported that loach peptides having a stronger reducing power contained histidine, methionine, tryptophan, lysine, and tyrosine in theirs sequences. Rapeseed fraction with the strongest reducing power had abundant hydrophobic amino acids, which were considered to contribute to enhancing the reducing power of peptides (Zhang et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Preventive effect of Nile tilapia hydrolysate against oxidative damage of HepG2 cells and DNA mediated by H2O2 and AAPH

et al. 2015

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Antioxidant activities of protein hydrolysate prepared from Nile tilapia protein isolate using Alcalase (HA), Alcalase followed by papain (HAPa) and their Sephadex G-25 fractions (FHA and FHAPa) were investigated in both chemical and cellular based models. Amongst all samples, FHAPa showed the highest chemical antioxidant activities, however it had no metal chelation activity. Cellular antioxidant ability of HA, HAPa and their fractions against H 2 O 2 and AAPH induced oxidative damage of HepG2 cell and DNA were tested. When cells were pretreated with all hydrolysates or fractions at different concentrations (0.5-2 mg/mL) in the absence and presence of 50 μM Trolox, cell viability was in the range of 91.10-111.40 %. However, no difference in cell viability was observed among samples having various concentrations (P>0.05). Cell reactive oxygen species (ROS) generation as mediated by H 2 O 2 and AAPH decreased with treatment of hydrolysates or their fractions, especially in combination with 50 μM Trolox. FHAPa effectively inhibited H 2 O 2 and peroxyl radical induced DNA scission in a dose dependent manner. Therefore, Nile tilapia protein hydrolysates could serve as a functional food ingredient.

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“…Fatigue will happen when the glycogen is mostly consumed. So glycogen is a sensitive index to test fatigue (You, Zhao, Regenstein, & Ren, 2011). In our study, LG levels in CRW groups were significantly higher than that in control group ( p < 0.05), indicating that CRW can significantly increase the content of LG after swimming.…”

Section: Discussionmentioning

confidence: 99%

“…Protein and amino acids have a stronger catabolic metabolism when body cannot obtain enough energy by sugar and fat catabolic metabolism. The catabolism of protein and amino acid will be strengthened along with the increase of training intensity, which contribute to increase the level of BUN (You et al., 2011). Our results showed that CRW can significantly decrease the levels of BLA and BUN after swimming, which suggested the antifatigue effect of CRW.…”

Section: Discussionmentioning

confidence: 99%

Antifatigue and antiaging effects of Chinese rice wine in mice

Zhao

Wang

Zhao

et al. 2018

Food Science & Nutrition

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Chinese rice wine (CRW) is widely known for keeping good health and commonly used in the traditional Chinese medicine prescription guiding drug. This study assesses the effects of CRW on antifatigue and antiaging activities in mice models. Mice were randomly divided into four groups performing with 0.25 ml of distilled water, 0.15, 0.25, and 0.4 ml of CRW for 15 consecutive days. The CRW could obviously increase the content of liver glycogen (LG) and decrease the levels of blood lactic acid (BLA)and blood urea nitrogen (BUN) to improve antifatigue ability. In antiaging assay, CRW significantly increased the activity of SOD in liver, the activities of GSH‐Px and CAT in brain cortex, body quality, thymus index, and spleen index, and decreased liver MDA levels, liver total cholesterol content, and AChE levels in hippocampus. The CRW has potent antifatigue ability and could minimize the occurrence of age‐associated disorders.

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In vitro antioxidant activity and in vivo anti-fatigue effect of loach (Misgurnus anguillicaudatus) peptides prepared by papain digestion

Cited by 260 publications

References 28 publications

Beneficial effects of fermented sardinelle protein hydrolysates on hypercaloric diet induced hyperglycemia, oxidative stress and deterioration of kidney function in wistar rats

Beneficial effects of fermented sardinelle protein hydrolysates on hypercaloric diet induced hyperglycemia, oxidative stress and deterioration of kidney function in wistar rats

Preventive effect of Nile tilapia hydrolysate against oxidative damage of HepG2 cells and DNA mediated by H2O2 and AAPH

Antifatigue and antiaging effects of Chinese rice wine in mice

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