In vitro Antioxidant Activity of Salacia lehmbachii Ethanol Root Bark Extract

Akuodor, Godwin Christian; Essiet, Grace Akanimo; Essien, A; Udoh, Francis V.; Ogiji, Emeka; Nwadum, Solomon K.; Nworie, Emmanuel

doi:10.9734/ejmp/2017/32014

Cited by 2 publications

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“…The leaves are important in such conditions as pyrexia, diarrhea, motility and ulcers (5,6). The extracts from the root have antioxidants (7), analgesic, anti-inflammatory (8), anti-cholinergic (9), anti-infertility (10) and anti-hemorrhoid effects (11). The present study investigated the antidiarrheal and antimicrobial activities of ethanol extract of S. lehmbachii root bark.…”

Section: Introductionmentioning

confidence: 99%

Antidiarrhoael and antimicrobial effects of ethanol root bark extract from Salacia lehmbachii

Akuodor

Essiet

Ekenjoku

et al. 2021

J Herbmed Pharmacol

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Introduction: The roots of Salacia lehmbachii are used in Nigerian folklore medicine without scientific basis. The present study was aimed to investigate the antidiarrheal and antimicrobial activities of the ethanol extract of S. lehmbachii root bark. Methods: The antidiarrheal activity was examined using castor oil induced diarrhoea method. The ethanol root bark extract effects on intestinal transit time and enteropooling were also evaluated in rats, while antimicrobial activity was conducted on selected microorganisms. The acute toxicity test and phytochemical screening of the extract were also carried out. Results: The extract produced significant (P < 0.05) dose dependent protection on rats against castor oil induced diarrhoea. The extract inhibited intestinal transit time and caused significant dose related inhibition of castor oil induced enteropooling in rats, comparable to the standard drug, atropine (P < 0.05). The root bark extract significantly and dose dependently delayed the onset of castor oil induced diarrhoea, reduced the frequency of defecation and decreased the severity of diarrhoea in rats. S. lehmbachii ethanol root bark extract significantly and dose dependently decreased the volume of intestinal fluid accumulation in the castor oil induced enteropooling. The extract also significantly inhibited the growth of test organisms. The acute toxicity test produced no lethality in rats, whereas the phytochemical analysis revealed the presence of alkaloids, saponins, tannins, flavonoids, terpenoids, steroids, cardiac glycosides, resins and balsam. Conclusion: The results of this study confirm the ethnomedicinal use of S. lehmbachii root bark as a valuable natural agent for the treatment of diarrhoea and microbial infections.

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Section: Introductionmentioning

confidence: 99%

Antidiarrhoael and antimicrobial effects of ethanol root bark extract from Salacia lehmbachii

Akuodor

Essiet

Ekenjoku

et al. 2021

J Herbmed Pharmacol

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“…6,7 More so, anticholinergic activity, anti-infertility and anti-hemorroid effects, as well as antioxidant activity were studied. [8][9][10][11] The objective of this study was to evaluate the anti-nociceptive, anti-inflammatory and antipyretic activities of ethanol extract of S. lehmbachii root bark in rats and mice.…”

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confidence: 99%

Anti-nociceptive, anti-inflammatory and antipyretic activities of the ethanol root bark extract of Salacia lehmbachii in rats and mice

Akuodor¹,

Ohadoma

Ofor

et al. 2021

Int J Basic Clin Pharmacol

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Background: The decoction of the roots of Salacia lehmbachi is used in traditional medicine for the treatment different diseases such as malaria pains diabetes and microbial infections.Methods: Phytochemical screening and oral acute toxicity tests were carried out on the ethanol root extract of the plant. Anti-nocicetive activity using acetic acid induced writhing and tail immersion method in mice, anti-inflammatory activity using carrageenan induced paw oedema in rats and xylene induced ear oedema test in mice and antipyretic activity using Brewer’s yeast and D-amphetamine induced pyrexia in rats were determined at 50 mg/kg, 100 mg/kg and 200 mg/kg doses of the root extract.Results: The ethanol root extract contain alkaloids, saponins, tannins, flavonoids, terpenoids, steroids and cardiac glycosides. The oral acute toxicity tests was found to be greater than 5000 mg/kg. The root extract and the standard drug (Aspirin) significantly (p<0.05 and p<0.01) decreased the number of writhes caused by acetic acid. The extract and morphine significantly (p<0.05 and p<0.01) prolonged reaction time in tail immersion model. The extract produced significant (p<0.05 and p<0.01) dose dependent inhibition of oedema which was comparable to aspirin in carrageenan induced paw oedema model. The root extract also demonstrated significant (p<0.05 and p<0.01) effect in xylene induced mouse ear oedema test compared to dexamethasone. The extract significantly decreased high temperature in both Brewer’s yeast and d-amphetamine induced pyrexia.Conclusions: Findings show that S. lehmbachii may provide a good source of plant compounds with analgesic, anti-inflammatory and antipyretic activities.

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In vitro Antioxidant Activity of Salacia lehmbachii Ethanol Root Bark Extract

Cited by 2 publications

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Antidiarrhoael and antimicrobial effects of ethanol root bark extract from Salacia lehmbachii

Antidiarrhoael and antimicrobial effects of ethanol root bark extract from Salacia lehmbachii

Anti-nociceptive, anti-inflammatory and antipyretic activities of the ethanol root bark extract of Salacia lehmbachii in rats and mice

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