In vitro antioxidant activity of tissue extracts of green mussel Perna viridis

Sreejamole, K. L.; Radhakrishnan, C. K.

doi:10.6024/jmbai.2016.58.2.1947a-14

Cited by 7 publications

(6 citation statements)

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“…In the present study the EtOAc-MeOH extracts derived from the bivalve clams demonstrated higher TPC content, which might explain the greater ABTS and DPPH radical scavenging properties. The methanolic and EtOAc extract of bivalve mollusk, Perna viridis were reported to exhibit considerable scavenging property against DPPH radical, which support the outcome of the present study (Jena et al 2010;Sreejamole and Radhakrishnan 2013).…”

Section: Discussionsupporting

confidence: 89%

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Comparative Bioactive Properties of Bivalve Clams Against Different Disease Molecular Targets

Joy

Chakraborty

Vijayagopal

2016

Journal of Food Biochemistry

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Clams occupy a predominant share of the edible bivalve mollusks in the coastal regions, and are important seafood resources. Antioxidant, anti-diabetic, antiinflammatory and antihypertensive potential of ethyl acetate-methanol (EtOAcMeOH) extract of bivalve clams, Villorita cyprinoides and Paphia malabarica were evaluated using various in vitro systems. EtOAc-MeOH fraction of P. malabarica demonstrated greater 1, 1-diphenyl-2-picryl-hydrazil (0.76 mg/mL) and 2, 2 0 -azinobis-3-ethylbenzothiozoline-6-sulfonic acid (1.27 mg/mL) radical scavenging ability. A greater anti-ACE, anti-COX-2/5-LOX properties (1.11, 0.92 and 1.51 mg/mL, respectively), along with DPP-IV (1.00 mg/mL) and a-glucosidase (1.47 mg/mL) inhibitory activities were recorded in the EtOAc-MeOH fraction of P. malabarica than V. cyprinoides. A significant co-linearity was found between various bioactive properties and the down-fielded electronegative groups present in the 1 H-NMR spectra of the crude EtOAc-MeOH fractions of bivalve clams. The current findings showed the importance of the bivalves as potential source of antioxidative leads for use as functional food supplements to combat oxidative stress-induced diseases. PRACTICAL APPLICATIONSThe edible bivalve clams, V. cyprinoides and P. malabarica are broadly available in the coastal regions of India and demonstrated to possess a number of bioactivities against different disease targets induced by free radical formation. The EtOAcMeOH fractions obtained from these bivalve clams recorded the COX-1 and COX-2 ratio of greater than 2.0 compared with NSAIDs (<1.0), which implied their greater selectivity against inflammatory responses and lesser side effect profiles. This study demonstrated the candidacy of the bivalves particularly, P. malabarica as potential source of bioactive leads for use as functional food supplements to deter deleterious free radical induced diseases, such as, inflammation, diabetes and hypertension.

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Section: Discussionsupporting

confidence: 89%

“…The methanolic and EtOAc extract of bivalve mollusk, Perna viridis were reported to exhibit considerable scavenging property against DPPH radical, which support the outcome of the present study (Jena et al . ; Sreejamole and Radhakrishnan ).…”

Section: Discussionmentioning

confidence: 99%

Comparative Bioactive Properties of Bivalve Clams Against Different Disease Molecular Targets

Joy

Chakraborty

Vijayagopal

2016

Journal of Food Biochemistry

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“…The decreasing order of antiproliferative activity in different cell lines was found as Hep-G2 > MCF-7 > IMR32 > HeLa = A549. A similar result was observed in studies conducted by Sreejamole and Radhakrishnan [41]. They found phenols, flavonoids and alkaloids as prime factors responsible for such antiproliferative activity.…”

Section: Discussionsupporting

confidence: 88%

Polyphenols From Cutch Tree ( Acacia catechu Willd.): Normalize In Vitro Oxidative Stress and Exerts Antiproliferative Activity

Kumar

Arora

Mahajan

et al. 2018

Braz. arch. biol. technol.

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“…The increment in mortality with these plant fractions was significantly higher than positive control at all duration times. The nauplii attain the second and third instars of their life cycle within 48 hours hence reveal their greatest sensitivity to toxins at this time (Sreejamole and Radhakrishnan, 2013). However, the findings of this study indicate that the maximum sensitivity was reached after 72 hours of exposure.…”

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confidence: 54%

Antifungal activity and brine shrimp toxicity assessment of <i>Bulbine abyssinica</i> used in the folk medicine in the Eastern Cape Province, South Africa

Kibiti

Afolayan

2016

Bangladesh J Pharmacol

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Bulbine abyssinica is widely used in folk medicine in Eastern Cape Province, South Africa. The aim of this study was to evaluate the antifungal and toxicity potentials of essential oil, acetone and aqueous extracts of this species using standard procedures and brine shrimp test, respectively. The results showed that the species was active against the growth of Microsporum canis, Microsporum gypseum and Trichophyton rubrum among the evaluated opportunistic fungi. The toxicity results showed that the lowest cysts hatching success was observed with the essential oil, then acetone extract, with aqueous extract exhibiting the highest hatching success. Based on the criterion of toxicity indices of the lethality test, all the plant fractions exhibited LD50 values greater than 1 mg/mL hence are non-toxic. These findings indicate that B. abyssinica is a good source of antifungal agents.

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In vitro antioxidant activity of tissue extracts of green mussel Perna viridis

Cited by 7 publications

References 0 publications

Comparative Bioactive Properties of Bivalve Clams Against Different Disease Molecular Targets

Comparative Bioactive Properties of Bivalve Clams Against Different Disease Molecular Targets

Polyphenols From Cutch Tree ( Acacia catechu Willd.): Normalize In Vitro Oxidative Stress and Exerts Antiproliferative Activity

Antifungal activity and brine shrimp toxicity assessment of <i>Bulbine abyssinica</i> used in the folk medicine in the Eastern Cape Province, South Africa

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