In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol

Shi, Qiankun; Wang, Xinya; Tang, Xudong; Zhen, Nuo; Wang, Yupeng; Luo, Zhigang; Zhang, Hao; Liu, Jingsheng; Zhou, Dongfang; Huang, Keke

doi:10.1002/fsn3.2302

Cited by 21 publications

(14 citation statements)

References 33 publications

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“…However, RES-UA NPs exhibited increased ROS scavenging activity with decreasing pH values because RES-UA NPs could release higher amounts of RES from the NPs, as shown in Figure 3 . Additionally, RES-UA NPs displayed dose-dependent ROS scavenging activity at pH 5.0, which was associated with the amount of RES released from the NPs, consistent with the findings of previous studies [ 49 , 50 ].…”

Section: Resultssupporting

confidence: 90%

In Vitro Anti-Inflammatory and Antioxidant Activities of pH-Responsive Resveratrol-Urocanic Acid Nano-Assemblies

Song

Kang

Jung

et al. 2023

IJMS

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Inflammatory environments provide vital biochemical stimuli (i.e., oxidative stress, pH, and enzymes) for triggered drug delivery in a controlled manner. Inflammation alters the local pH within the affected tissues. As a result, pH-sensitive nanomaterials can be used to effectively target drugs to the site of inflammation. Herein, we designed pH-sensitive nanoparticles in which resveratrol (an anti-inflammatory and antioxidant compound (RES)) and urocanic acid (UA) were complexed with a pH-sensitive moiety using an emulsion method. These RES-UA NPs were characterized by transmission electron microscopy, dynamic light scattering, zeta potential, and FT-IR spectroscopy. The anti-inflammatory and antioxidant activities of the RES-UA NPs were assessed in RAW 264.7 macrophages. The NPs were circular in shape and ranged in size from 106 to 180 nm. The RES-UA NPs suppressed the mRNA expression of the pro-inflammatory molecules inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in a concentration-dependent manner. Incubation of LPS-stimulated macrophages with RES-UA NPs reduced the generation of reactive oxygen species (ROS) in a concentration-dependent manner. These results suggest that pH-responsive RES-UA NPs can be used to decrease ROS generation and inflammation.

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Section: Resultssupporting

confidence: 90%

In Vitro Anti-Inflammatory and Antioxidant Activities of pH-Responsive Resveratrol-Urocanic Acid Nano-Assemblies

Song

Kang

Jung

et al. 2023

IJMS

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“…The XRD pattern of complexes and their constituents were determined ( Figure 1 b) to confirm the complexation between resveratrol and phosphatidylcholine. Pure resveratrol showed the characteristic peaks at 6.66, 16.3, 19.7, 22.52, 23.66, 25.24, and 28.3, demonstrating the crystalline form of resveratrol [ 36 ]. A large (wide) diffraction peak was observed for phosphatidylcholine, indicating the amorphous structure of phosphatidylcholine.…”

Section: Resultsmentioning

confidence: 99%

A QbD Approach to Design and to Optimize the Self-Emulsifying Resveratrol–Phospholipid Complex to Enhance Drug Bioavailability through Lymphatic Transport

et al. 2022

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Objectives: Despite having profound therapeutic value, the clinical application of resveratrol is restrained due to its <1% bioavailability, arising from the extensive fast-pass effect along with enterohepatic recirculation. This study aimed to develop a self-emulsifying formulation capable of increasing the bioavailability of resveratrol via lymphatic transport. Methods: The resveratrol–phospholipid complex (RPC) was formed by the solvent evaporation method and characterized by FTIR, DSC, and XRD analyses. The RPC-loaded self-emulsifying drug delivery system (SEDDS) was designed, developed, and optimized using the QbD approach with an emphasis on resveratrol transport through the intestinal lymphatic pathway. The in vivo pharmacokinetic study was investigated in male Wister Albino rats. Results: The FTIR, DSC, and XRD analyses confirmed the RPC formation. The obtained design space provided robustness of prediction within the 95% prediction interval to meet the CQA specifications. An optimal formulation (desirability value of 7.24) provided Grade-A self-emulsion and exhibited a 48-fold bioavailability enhancement compared to the pure resveratrol. The cycloheximide-induced chylomicron flow blocking approach demonstrated that 91.14% of the systemically available resveratrol was transported through the intestinal lymphatic route. Conclusions: This study suggests that an optimal self-emulsifying formulation can significantly increase the bioavailability of resveratrol through lymphatic transport to achieve the desired pharmacological effects.

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“…With IC 50 values of 14.73 and 17.84 g mL -1 , respectively, this nanosystem also demonstrated more antiproliferative activity than free resveratrol in 4T1 murine breast cancer cells. [55] By encasing antioxidants in nanoparticles, researchers can increase the compounds' bioavailability, biodistribution and capacity to target specific tissues or receptors, resulting in a regulated release of chemicals over an extended period of time.…”

Section: Nanoparticle-mediated Suspension Of Moderate Oxidative Stres...mentioning

confidence: 99%

Nanomedicine-based modulation of redox status for cancer therapy

Park

Nice

et al. 2023

Aust. J. Chem.

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Cancer has always been a major disease with an unfavorable impact on human health worldwide. Redox biology has a close and complicated relationship to the initiation and progression of cancer. Continuous work is being conducted to develop novel approaches for cancer prevention and therapy by modulating redox homeostasis, but problems in drug targeting, drug resistance, adverse effects and recurrence are persistent challenges. Nanotechnology is emerging as a powerful tool to achieve specific targeting, non-invasive therapeutics, high therapeutic efficiency and improved drug sensitivity for cancers by exploiting the features of their microenvironment, especially the redox properties. In addition, nanoplatform-mediated delivery of anticancer drugs or exogenous antioxidants/oxidants affords a promising prospect for cancer therapy. In this review, we will summarize recent advances in redox species-responsive nanoplatforms for tumor treatment. Current nanocarrier mediated strategies that manage redox status for cancer treatment will also be discussed.

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In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol

Cited by 21 publications

References 33 publications

In Vitro Anti-Inflammatory and Antioxidant Activities of pH-Responsive Resveratrol-Urocanic Acid Nano-Assemblies

In Vitro Anti-Inflammatory and Antioxidant Activities of pH-Responsive Resveratrol-Urocanic Acid Nano-Assemblies

A QbD Approach to Design and to Optimize the Self-Emulsifying Resveratrol–Phospholipid Complex to Enhance Drug Bioavailability through Lymphatic Transport

Nanomedicine-based modulation of redox status for cancer therapy

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