In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum

Inbaneson, Samuel Jacob; Sundaram, Ramalingam; Suganthi, Palavesam

doi:10.1016/s2221-1691(12)60057-4

Cited by 23 publications

(9 citation statements)

References 25 publications

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“…Crude methanol leaf extract of J .curcas had similar larvicidal activity to 0.5ppm Temephos at test concentrations ranging from 125-1000ppm while Column chromatographic fractions (F1 and F2) of crude methanol leaf extract of J. curcas showed similar larvicidal activities to 0.5ppm Temephos at 62.5 and 125ppm test concentrations. This investigation is similar to study by Samuel et al, 54 which indicated that J. glandulifera showed excellent antiplasmodial activity.…”

Section: Parts Used Leafsupporting

confidence: 92%

Phytochemical-constituents, safety and efficacy of commonly used medicinal plants for the treatment of malaria in Ethiopia-a review

Abera¹,

Ashebir²,

Basha³

et al. 2019

PPIJ

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Background: Malaria is among the ten top leading causes of morbidity and mortality in children under-5 years. Due to the rise of drug-resistant parasites and limited therapeutic efficacy of the available drugs, there is a need to search novel antimalarial drugs from medicinal plants commonly utilized as traditional medicines. Traditional medicines are often more available, affordable, sometimes are perceived as more effective than conventional antimalarial drugs, cultural acceptable and the relatively lower cost. Hence traditional medicine becomes the novel candidate for the search and development of drugs for the prevention and treatment of malaria.Objective: The present study aimed to review phytochemical constitute, safety and efficacy commonly used medicinal plants for malaria treatment in Ethiopia. Methods:A web-based literature search was done by using scientific databases including Pub Med, Science Direct, Web of Science and Google Scholar, with inclusion criteria of full length experimental, ethno-botanical and ethno medicinal survey articles reporting on anti-malarial medicinal plants conducted in Ethiopia. Results: The most commonly utilized medicinal plants for the treatment of malaria were Conclusion and recommendation: Aqueous leaf extract of Strychnos mitis possessed a potent chemo suppression of 95.5 % at a dose of 600mg/kg/day. Further chemical isolation, dosage form development, clinical trial, and toxicological study is recommended. Citation: Abera T, Ashebir R, Basha H, et al. Phytochemical-constituents, safety and efficacy of commonly used medicinal plants for the treatment of malaria in Ethiopia-a review.

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Section: Parts Used Leafsupporting

confidence: 92%

Phytochemical-constituents, safety and efficacy of commonly used medicinal plants for the treatment of malaria in Ethiopia-a review

Abera¹,

Ashebir²,

Basha³

et al. 2019

PPIJ

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“…The oceans have an abundance of bioactive natural products [1] , many of which exhibit extraordinary chemical and structural features [2] – [4] . Likewise, there are special kinds of living organisms around the oceans, such as coastal plants [5] , [6] , some of which have pharmacological activities and therapeutic effects [7] , [8] . For example, Ipomoea pes-caprae , a species in the Convolvulaceae family, is recognized to have anti-nociceptive and anti-inflammatory activity [9] – [11] , and is used in Chinese traditional medicine to treat rheumatic diseases.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Activity of N-Butanol Extract from Ipomoea stolonifera In Vivo and In Vitro

et al. 2014

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Ipomoea stolonifera (I. stolonifera) has been used for the treatment of inflammatory diseases including rheumatism and rheumatoid arthritis in Chinese traditional medicine. However, the anti-inflammatory activity of I. stolonifera has not been elucidated. For this reason, the anti-inflammatory activity of n-butanol extract of I. stolonifera (BE-IS) was evaluated in vivo by using acute models (croton oil-induced mouse ear edema, carrageenan-induced rat paw edema, and carrageenan-induced rat pleurisy) and chronic models (cotton pellet-induced rat granuloma, and complete Freund’s adjuvant (CFA)-induced rat arthritis). Results indicated that oral administration of BE-IS significantly attenuated croton oil-induced ear edema, decreased carrageenan-induced paw edema, reduced carrageenan-induced exudates and cellular migration, inhibited cotton pellet-induced granuloma formation and improved CFA-induced arthritis. Preliminary mechanism studies demonstrated that BE-IS decreased the levels of myeloperoxidase (MPO) and malondialdehyde (MDA), increased the activity of anti-oxidant enzyme superoxide dismutase (SOD) in vivo, and reduced the production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 in lipopolysaccharide-activated RAW264.7 macrophages in vitro. Results obtained in vivo and in vitro demonstrate that BE-IS has considerable anti-inflammatory potential, which provided experimental evidences for the traditional application of Ipomoea stolonifera in inflammatory diseases.

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“…Phytochemical screening Preliminary phytochemical analysis of methanolic extract of Achyranthes aspera shoot was done following method described by (Harbone, 1984).…”

Section: Plant Extractionmentioning

confidence: 99%

“…In view of their proven use in the production of treatment outcome for human infection, thus these models remain a standard part of drug discovery and development pathway (Fidock et al, 2004). The study conducted by (Inbaneson et al, 2012) on the antiplasmodial activity of the leaf, stem, and root extracts of Achyranthes aspera in vitro reports that plants were effective against Plasmodium falciparum with IC50 values between 50 and 100 μg/ml. Following literature reports on antimalarial activity of Achyranthes aspera reveals that, the shoot part of the plant has little or not been investigated despite its vital chemicals and antimicrobial activity (Parvenu, 2018).…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial Activity of Methanolic Extract of Achyranthes aspera Shoot against Plasmodium berghei Infection in Albino Mice

2021

Russian Journal of Biological Research

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Malaria remains one of the diseases that lack satisfactory treatment worldwide and continued to pose serious challenges with rapid spread of resistant parasite. Achyranthes aspera leaf, stem, and root extracts were found to exhibit antiplasmodial activities. The shoot has little or not been investigated despite its vital chemicals. Based on this, the study attempted to investigate antiplasmodial activity of methanol extract Achyranthes aspera shoot against Plasmodium berghei infection in mice. Achyranthes aspera shoot was sliced, air-dried, then pulverized into powdered form then extracted with methanol, filtered and concentrated with rotary evaporator at 40 o C. The crude extract obtained was subjected to phytochemical analysis followed by acute toxicity study. Antiplasmodial effect of the extract was investigated in Swiss albino mice infected with 1x10 7 Plasmodium berghei (NK-65) strain intrperitonealy. Eight groups of 5 mice were used; group 1: normal control, group 2: infected mice and untreated, group 3&4: infected mice + standard drugs, group 5-7: infected mice + extracts (200 mg/kg, 400 mg/kg, 600 mg/kg body wt.), group 8: infected mice + vehicle. During the experiment, parasitemia levels and PCV were monitored. Body weight and temperature were also measured.The study found that the plant shoot contains vital phytochemicals (alkaloids, saponins, phenols and flavonoids) and is safe with LD50 greater than 5000 mg/kg body weight of extract of mice. Treating Plasmodium berghei infected mice with methanol extract of the plant shoot displayed remarkable effect as evidenced by the reduction in their parasitemia levels and increase survival rate in a manner comparable to chloroquine and artemisinin. The methanol extract of A. aspera is safe, possess vital phytochemicals and exhibited antiplasmodial activity in mice. As it is a good antimalarial candidate, further research should characterize the active component(s) and their mode of action.

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In vitro antiplasmodial effect of ethanolic extracts of coastal medicinal plants along Palk Strait against Plasmodium falciparum

Cited by 23 publications

References 25 publications

Phytochemical-constituents, safety and efficacy of commonly used medicinal plants for the treatment of malaria in Ethiopia-a review

Phytochemical-constituents, safety and efficacy of commonly used medicinal plants for the treatment of malaria in Ethiopia-a review

Anti-Inflammatory Activity of N-Butanol Extract from Ipomoea stolonifera In Vivo and In Vitro

Antiplasmodial Activity of Methanolic Extract of Achyranthes aspera Shoot against Plasmodium berghei Infection in Albino Mice

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