In vitro Antiproliferative Activity of Endemic Centaurea kilaea Boiss. against Human Tumor Cell Lines

Şen, Ali; Ozbas, Suna Turan; Akbuğa, Jülide; Bitiş, Leyla

doi:10.5455/musbed.20150602022750

Cited by 10 publications

(14 citation statements)

References 15 publications

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“…Sary et al reported that Centaurea aegyptiaca extract had cytotoxic effect on HepG2 cells [5]. According to another study, it was reported that Centaurea kilaea Boiss extract had cytotoxic effects on various cancer cell lines [6]. In the present study, C. cuneifolia, C. kilaea, C. salicifolia chloroform extracts showed a dramatically increased cytotoxic effect in less than 24 h on hepatocarcinoma cell line HepG2.…”

Section: Discussionsupporting

confidence: 55%

Anticancer, Antioxidant and Anti-Inflammatory Activities of Chloroform Extracts from Some Centaurea Species

Şekerler

Şen

Bitiş

et al. 2018

The 2nd International Cell Death Research Congress

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The aim of this study was to investigate the anticancer activities of five chloroform extracts prepared from the aerial parts of Centeura kilaea Boiss. (CKC), C. cuneifolia Sm. (CCC), C. salicifolia M.Bieb. ex Willd. (CSAC), C. stenolepis Kerner (CSC1 and CSC2) against hepatocellular cancer HepG2 cell line. At the same time, antioxidant and anti-inflammatory activities of the extracts were examined. Anticancer, anti-inflammatory, antioxidant activities of extracts were carried out by MTT, lipoxygenase, DPPH-ABTS methods, respectively. CCC, CSAC and CKC have the highest anticancer activity when compared to other extracts. Similarly, CSAC and CCC had the best antioxidant capacity, while CSAC and CKC showed strong anti-lipoxygenase activity. Among all the tested extracts, the highest amounts of total phenolic were found in the CSAC. The study revealed that CSAC and CCC displays remarkable antioxidant, anticancer and anti-inflammatory activity.

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Section: Discussionsupporting

confidence: 55%

Anticancer, Antioxidant and Anti-Inflammatory Activities of Chloroform Extracts from Some Centaurea Species

Şekerler

Şen

Bitiş

et al. 2018

The 2nd International Cell Death Research Congress

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“…CKCSII exhibited the best anti-proliferative activity against human tumour cell lines according to our previous study (Sen et al. 2015 ). Therefore, we attempted to isolate compounds responsible for activity of CKCSII in this study.…”

Section: Methodssupporting

confidence: 54%

“…Extracts and sub-fractions of C. kilaea were obtained in our previous study (Sen et al. 2015 ). Briefly, dried aerial parts of C. kilaea were macerated separately in n -heptane, chloroform and methanol, with yield of 2.07, 4.01 and 8.40%, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Bioactivity-guided isolation of anti-proliferative compounds from endemic Centaurea kilaea

Şen

Turan

Bitiş

2016

Pharmaceutical Biology

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Context: The genus Centaurea L. (Asteraceae) is one of the largest genera in Turkey. Compounds and extracts obtained from different Centaurea species have significant anti-cancer activity against various cancer cell lines.Objective: To determine the anti-proliferative activity of isolates from the chloroform extract of C. kilaea Boiss.Materials and methods: Eleven compounds were isolated using column chromatography and preparative TLC from the chloroform extract of aerial parts of endemic C. kilaea. The structures of the isolated compounds were elucidated by various spectroscopic methods, including UV, lH-NMR and 13C-NMR. Anti-proliferative activity of compounds (0.5–50 μg/mL) were measured against one normal cell line (L-929, mouse fibroblast) and three human cancer cell lines (Hela, cervix carcinoma; MCF-7, breast carcinoma; PC-3, prostate carcinoma) using MTT assay. Results were expressed as IC50 values.Results: None of the 11 compounds displayed activity against L-929 and HeLa. Two of these compounds, cnicin and cirsimaritin, showed fairly strong activity against MCF-7 and PC-3 with IC50 values of 3.25 and 4.3 μg/mL, respectively.Discussion and conclusion: This is the first report on cirsimaritin. Cirsimaritin and cnicin could serve as potential anti-cancer drug candidates against breast and prostate cancer, respectively.

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“…Cell viability and anti-cancerogenic activity, and growth inhibition profile of the extracts were analyzed using the ISO-10993-5 in vitro cytotoxicity test-MTT assay (11).…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Endemik Tanacetum argenteum subsp. argenteum bitkisinin toprak üstü kısımlarından elde edilen ekstrelerin biyolojik aktiviteleri

Şen¹,

Özakpınar²,

Tan³

et al. 2017

Marmara Pharmaceutical Journal

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In vitro Antiproliferative Activity of Endemic Centaurea kilaea Boiss. against Human Tumor Cell Lines

Abstract: Ya zış ma Ad re si / Add ress rep rint re qu ests to: Leyla Bitiş Department of Pharmacognosy, Faculty of Pharmacy, Marmara University, Istanbul -Turkey Elekt ro nik pos ta ad re si / E-ma il add ress: leylabitis@marmara.edu.

Cited by 10 publications

References 15 publications

Anticancer, Antioxidant and Anti-Inflammatory Activities of Chloroform Extracts from Some Centaurea Species

Anticancer, Antioxidant and Anti-Inflammatory Activities of Chloroform Extracts from Some Centaurea Species

Bioactivity-guided isolation of anti-proliferative compounds from endemic Centaurea kilaea

Endemik Tanacetum argenteum subsp. argenteum bitkisinin toprak üstü kısımlarından elde edilen ekstrelerin biyolojik aktiviteleri

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