In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A–C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832

Umeyama, Akemi; Takahashi, Koichi; Grudniewska, Aleksandra; Shimizu, Mina; Hayashi, Saihou; Kato, Masayuki; Okamoto, Yasuko; Suenaga, Masaya; Ban, Sayaka; Kumada, Toshio; Ishiyama, Aki; Iwatsuki, Masato; Otoguro, Kazuhiko; Ōmura, Satoshi; Hashimoto, Toshihiro

doi:10.1038/ja.2013.93

Cited by 24 publications

(15 citation statements)

References 19 publications

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“…Compounds 1 and 2 exhibited potent antifungal activities against the plant pathogens C. gloeosporioides and C. musae, and compounds 1 and 3 towards F. oxysporum, yielding better results compared with the positive control carbendazim, thus indicating that these compounds could be potential antifungal agents. To date, cyclic hexadepsipeptides have been reported to possess diverse bioactivities, including antimalaria, antituberculosis, cytotoxic [28], acetylcholinesterase inhibitory [29], antitrypanosomal [30], anti-inflammatory [31], insecticidal [32], antibacterial [33], phtotoxic [34], and immunosuppressive [21] activities. However, only a few cyclic hexadepsipeptides have been reported to possess antifungal activities.…”

Section: Resultsmentioning

confidence: 99%

Fusarihexins A and B: Novel Cyclic Hexadepsipeptides from the Mangrove Endophytic Fungus Fusarium sp. R5 with Antifungal Activities

et al. 2018

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Two novel cyclic hexadepsipeptides, fusarihexin A (1: ) and fusarihexin B (2: ), and two known compounds, cyclo-(L-Leu-L-Leu-D-Leu-L-Leu-L-Val) (3: ) and cyclo-(L-Leu-L-Leu-D-Leu-L-Leu-L-Ile) (4: ), were isolated from the marine mangrove endophytic fungus sp. R5. Their chemical structures were elucidated on the basis of spectroscopic data and Marfey's analysis. In an bioassay, fusarihexin A (1: ) remarkably inhibited three plant pathogenic fungi: (Penz.) Sacc., which causes anthracnose in many fruits and vegetables, (Berk. and M. A. Curtis) Arx, which causes crown rot and anthracnose in bananas, and Schlecht. f. sp. lycopersici (Sacc.) W. C. Snyder et H. N. Hansen, which causes Fusarium wilt and fruit rot in tomatoes. Fusarihexin B (2: ) strongly inhibited and . The compounds were more potent than carbendazim, which is widely used as an agricultural and horticultural fungicide worldwide.

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Section: Resultsmentioning

confidence: 99%

Fusarihexins A and B: Novel Cyclic Hexadepsipeptides from the Mangrove Endophytic Fungus Fusarium sp. R5 with Antifungal Activities

et al. 2018

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“…Cardinalisamides A–C ( 32 – 34 ) were separated from C. cardinalis NBRC 103832. Cardinalisamides A–C showed antitrypanosomal activity against Trypanosoma brucei and their IC 50 were 8.56, 8.65 and 8.63 mg/mL, respectively, in vitro, and had IC 50 values of 18.48, 14.00 and 23.84 mg/mL, respectively, against normal human diploid fibroblasts (MRC-5 cells) in cytotoxicity assays [ 36 ]. Cordycecin A ( 35 ) and two known compounds beauvericins E ( 36 ) and J ( 37 ) were separated from the ascocarps and insect-body tranches of C. cicadae .…”

Section: Non-ribosomal Peptides and Alkaloidsmentioning

confidence: 99%

Metabolites and Their Bioactivities from the Genus Cordyceps

Liu

et al. 2022

Microorganisms

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The Cordyceps genus is a group of ascomycete parasitic fungi, and all known species of this genus are endoparasites; they mainly feed on insects or arthropods and a few feed on other fungi. Fungi of this genus have evolved highly specific and complex mechanisms to escape their host’s immune system and coordinate their life cycle coefficients with those of their hosts for survival and reproduction; this mechanism has led to the production of distinctive metabolites in response to the host’s defenses. Herein, we review approximately 131 metabolites discovered in the genus Cordyceps (including mycelium, fruiting bodies and fungal complexes) in the past 15 years, which can be used as an important source for new drug research and development. We summarize chemical structures, bioactivity and the potential application of these natural metabolites. We have excluded some reports that originally belonged to Cordyceps, but whose taxonomic attribution is no longer the Cordyceps genus. This can and will serve as a resource for drug discovery.

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“…Fungal depsipeptides have recently been reviewed Molecules 2020, 25, 911 9 of 18 at length [64], therefore, this section will focus on a few selected depsipeptides. Depsipeptides have been isolated from many ascomycete fungi, including plant pathogenic species in the genera Fusarium, Alternaria, Calonectria and Cochliobolus [65] as well as entomopathogenic fungal species, such as Cordyceps cardinalis and Ophiocordyceps communis [66,67]. Many depsipeptides exhibit both antimicrobial and insecticidal activity, and have, therefore, attracted attention for potential use in the development of new drug and crop protection products.…”

Section: Depsipeptidesmentioning

confidence: 99%

Selected Fungal Natural Products with Antimicrobial Properties

Jakubczyk

Dussart

2020

Molecules

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Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal “toxins”. The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here.

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In vitro antitrypanosomal activity of the cyclodepsipeptides, cardinalisamides A–C, from the insect pathogenic fungus Cordyceps cardinalis NBRC 103832

Cited by 24 publications

References 19 publications

Fusarihexins A and B: Novel Cyclic Hexadepsipeptides from the Mangrove Endophytic Fungus Fusarium sp. R5 with Antifungal Activities

Fusarihexins A and B: Novel Cyclic Hexadepsipeptides from the Mangrove Endophytic Fungus Fusarium sp. R5 with Antifungal Activities

Metabolites and Their Bioactivities from the Genus Cordyceps

Selected Fungal Natural Products with Antimicrobial Properties

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