In vitro antiviral activity against <scp>SARS‐CoV</scp>‐2 of common herbal medicinal extracts and their bioactive compounds

Leka, K; Hamann, Carla; Desdemoustier, Pauline; Frédérich, Michel; Garigliany, Mutien-Marie; Ledoux, Allison

doi:10.1002/ptr.7463

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…In addition, it was shown that different species of cinnamon could hold molecules that block the viral main protein M pro and other spike proteins, disrupting both the entry and the proliferation of the virus through a lack of major components for the viral cell cycle [ 127 ]. In a recent study carried out in 2022, the half-maximal anti-viral activity of cinnamon’s essential oil against SARS-CoV-2 was approximately 50 μg/mL [ 128 ]. Moreover, the chemical characterization of C. verum ’s water and ethanolic extracts showed the presence of 27 and 23 compounds, respectively.…”

Section: Cinnamomum Verum ( C Verum )mentioning

confidence: 99%

Treating COVID-19 with Medicinal Plants: Is It Even Conceivable? A Comprehensive Review

Al-Jamal,

Idriss,

Roufayel

et al. 2024

Viruses

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In 2020, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) challenged the world with a global outbreak that led to millions of deaths worldwide. Coronavirus disease 2019 (COVID-19) is the symptomatic manifestation of this virus, which can range from flu-like symptoms to utter clinical complications and even death. Since there was no clear medicine that could tackle this infection or lower its complications with minimal adverse effects on the patients’ health, the world health organization (WHO) developed awareness programs to lower the infection rate and limit the fast spread of this virus. Although vaccines have been developed as preventative tools, people still prefer going back to traditional herbal medicine, which provides remarkable health benefits that can either prevent the viral infection or limit the progression of severe symptoms through different mechanistic pathways with relatively insignificant side effects. This comprehensive review provides scientific evidence elucidating the effect of 10 different plants against SARS-CoV-2, paving the way for further studies to reconsider plant-based extracts, rich in bioactive compounds, into more advanced clinical assessments in order to identify their impact on patients suffering from COVID-19.

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Section: Cinnamomum Verum ( C Verum )mentioning

confidence: 99%

Treating COVID-19 with Medicinal Plants: Is It Even Conceivable? A Comprehensive Review

Al-Jamal,

Idriss,

Roufayel

et al. 2024

Viruses

View full text Add to dashboard Cite

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“…4 The ethanol extract of C. verum ethanol was also previously evaluated in vitro against SARS-CoV-2. 5 Moreover, recent research on C. verum water and ethanol extracts were reported to inhibit the binding of SARS-CoV-2 spike protein to ACE2 in a dose-dependent manner. 6 Essential oils are known for their antiviral activity against human herpes viruses, HIV, and influenza viruses.…”

Section: Introductionmentioning

confidence: 99%

“…The ethanol extract of C. verum ethanol was also previously evaluated in vitro against SARS-CoV-2 . Moreover, recent research on C.…”

Section: Introductionmentioning

confidence: 99%

Enzyme-Based Antiviral Potential of Cinnamomum verum J. Presl. Essential Oil and Its Major Component (E)-Cinnamaldehyde

Karadağ,

Biltekin,

Ghani

et al. 2024

ACS Omega

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In the present study, Cinnamomum verum J. Presl. bark essential oil and its main component cinnamaldehyde was evaluated in vitro for neuraminidase (NA), transmembrane serine protease (TMPRSS2), and angiotensin converting enzyme 2 (ACE2) inhibitory activities. The chemical composition of C. verum essential oil was confirmed by both gas chromatography−mass spectrometry (GC/MS), and gas chromatography−flame ionization detection (GC-FID), where 75.9% (E)-cinnamaldehyde was the major component. The ACE2, NA, and TMPRSS2 enzyme inhibitions of C. verum bark essential oil at 20 μg/ mL concentration, and (E)-cinnamaldehyde (5 μg/mL) were calculated and compared in the range of 54.2−89.9%. Molecular docking results supported that (E)-cinnam-aldehyde was specific to ACE2 with 89.9% inhibition. Our findings suggest further in vivo studies to confirm the effective and safe use of the essential oil as well as the (E)-cinnamaldehyde.

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“…Over 300 clinical trials have reported the beneficial protective effects of curcumin against various diseases including respiratory disease such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis, acute lung injury, inflammatory diseases such as inflammatory bowel disease (IBD), rheumatoid arthritis, psoriasis, neurological diseases, cardiovascular diseases, metabolic diseases, liver diseases, and cancers (26)(27)(28). Curcumin reportedly is also a broad-spectrum antiviral, inhibiting a variety of viruses such as SARS-CoV-1 (29), human immunodeficiency virus (HIV)-1, HIV2, herpes simplex virus (HSV), human papillomavirus (HPV), human T-lymphotropic virus-1 (HTLV1), hepatitis B virus (HBV), hepatitis C virus (HCV), influenza A virus, Japanese encephalitis virus (JEV) (30), and SARS-CoV-2 (31)(32)(33)(34).…”

mentioning

confidence: 99%

The possible therapeutic role of curcumin and quercetin in the early-stage of COVID-19—Results from a pragmatic randomized clinical trial

et al. 2023

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BackgroundCurcumin (CUR) and quercetin (QUE), two natural polyphenols, possess diverse biological activities including broad-spectrum antiviral, antioxidant, and immunomodulatory effects. Both CUR and QUE have shown inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in in vitro assays.ObjectiveIn the present study we aimed to assess the possible treatment benefits of a combined curcumin and quercetin (CUR-QUE) oral supplement, alongside standard of care (SOC), in the early-stage COVID-19 infection.MethodsThis was an exploratory, pragmatic, open-label, randomized controlled clinical trial, conducted at the Department of Pathology, Liaquat University of Medical and Health Sciences, Jamshoro, PK. The study compared the treatment effect of an oral CUR-QUE supplement plus SOC vs. SOC alone, in the early-stage/mild to moderately symptomatic COVID-19 outpatients. Patients were randomized in a 1:1 ratio to CUR-QUE (n = 25) and control (n = 25) treatment groups. The CUR-QUE supplementation consisted of a daily intake of 168 mg curcumin and 260 mg quercetin, as two soft capsules, to be taken twice a day at home for 14 days.ResultsAfter one-week of treatment, most of the patients in the CUR-QUE group showed an expedited clearance of the viral infection i.e., 18 (72.0%) vs. 6 (24.0%) patients in the control group tested negative for SARS-CoV-2 in the nasal-oropharyngeal swab reverse transcription-polymerase chain reaction (RT-PCR) analysis (p = 0.0002). In addition, COVID-19-associated acute symptoms were also speedily resolved in the CUR-QUE treated patients, i.e., 10 (40.0%) vs. 4 (16.0%) patients in the control group (p = 0.061). The CUR-QUE supplementation therapy was well-tolerated by all 25 patients and no treatment-emergent effects or serious adverse events were reported.ConclusionThe results revealed in this exploratory study suggest a possible therapeutic role of curcumin and quercetin in the early-stage of COVID-19. It is proposed that the two agents possibly acting in synergy, interfere the SARS-CoV-2 replication, and thus help a speedy recovery in the early-stage of COVID-19. Further research is highly encouraged.Clinical trial registrationClinicaltrials.gov, Identifier NCT04603690.

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In vitro antiviral activity against SARS‐CoV‐2 of common herbal medicinal extracts and their bioactive compounds

Cited by 8 publications

References 10 publications

Treating COVID-19 with Medicinal Plants: Is It Even Conceivable? A Comprehensive Review

Treating COVID-19 with Medicinal Plants: Is It Even Conceivable? A Comprehensive Review

Enzyme-Based Antiviral Potential of Cinnamomum verum J. Presl. Essential Oil and Its Major Component (E)-Cinnamaldehyde

The possible therapeutic role of curcumin and quercetin in the early-stage of COVID-19—Results from a pragmatic randomized clinical trial

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