In vitro assessment of Ag2O nanoparticles toxicity against Gram-positive and Gram-negative bacteria

Negi, Harshita; Saravanan, P.; Agarwal, Tithi; Zaidi, M. G. H.; Goel, Reeta

doi:10.2323/jgam.59.83

Cited by 25 publications

(16 citation statements)

References 25 publications

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“…Toxicities of n-ZnO and n-CuO to a bacterium (V. fischeri) and some crustaceans (D. magna and T. platyurus) were mostly due to dissolution of Zn 2+ and Cu 2+ J U S T A C C E P T E D (Heinlaan et al, 2008), which was significantly different with the toxic mechnisms of their nano state (Lubick, 2008 while PtO 2 and TcO 2 were less toxic (Predicted log 1/EC 50 < 1.6) (See Table S4, SI). This result is consistent with previously reported results (Negi et al, 2013). The reason for this is that s-, p-, and d-metals have different oxidation states.…”

Section: Discussionsupporting

confidence: 95%

Predicting toxic potencies of metal oxide nanoparticles by means of nano-QSARs

Zhao

et al. 2016

Nanotoxicology

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Section: Discussionsupporting

confidence: 95%

Predicting toxic potencies of metal oxide nanoparticles by means of nano-QSARs

Zhao

et al. 2016

Nanotoxicology

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“…Silver oxide has been used to treat bacterial infections in the start of nineteenth century but when the era of antibiotics began, along with the discovery of penicillin [9]. Among the wide range of nanoparticle choices available, silver oxide nanoparticles due to its wide range of antibacterial properties constitute a very encouraging loom for the advancement of new antimicrobial agents [10]. Ag 2 O nanoparticles exhibit antibacterial activity against both gram‐positive as well as gram‐negative bacteria but its efficiency is higher in case of gram‐negative bacteria.…”

Section: Introductionmentioning

confidence: 99%

Synergistic evaluation of AgO₂nanoparticles with ceftriaxone against CTXM and blaSHV genes positive ESBL producing clinical strains of Uro‐pathogenicE. coli

Sajjad

Uzair

Shaukat

et al. 2019

IET nanobiotechnol.

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The silver oxide nanoparticles (AgO 2-NPs) were synthesised using silver foil as a new precursor in wet chemical method. X-ray diffraction analysis shows crystallographic structures of AgO 2-NPs with crystallite size of 35.54 nm well-matched with standard cubic structure. Scanning electron microscopy analysis clearly shows the random distribution of spherical-shaped nanoparticles. Energy dispersive X-ray analysis confirmed the purity of the samples as it shows no impurity element. Fourier transforms infra-red analysis confirmed the formation of AgO 2-NPs with the presence of AgO -Ag stretching bond. All the techniques also confirmed the loading of ceftriaxone drug on the surface of AgO 2-NPs. This study also described the effect of AgO 2-NPs having synergistic activity with β lactam antibiotic i.e. ceftriaxone against ESBL generating Escherichia coli (E. coli). Among isolated strains of E. coli, 60.0% were found to be ESBL producer. The synergistic activities of AgO 2-NPs with ceftriaxone suggest that these combinations are effective against MDR-ESBL E. coli strains as evident by increase in zone sizes. The present study observed rise in MDR-ESBL E. coli with polymorphism of blaCTXM and blaSHV causing UTI infections in Pakistani population. The antibiotic and AgO 2-NPs synergistic effect can be used as an efficient approach to combat uropathogenic infections.

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“…Furthermore, MBC determinations showed that S. aureus presented lower sensitivity to MMT-Ag than E. coli. This was also described for silver ions, Ag 2 O, and AgNPs, and was attributed to the thick peptidoglycan layer in the cell wall of gram-positive microorganisms 4,5,46 .…”

Section: E Coli Atcc 25922 Dark Zones In the Agar Plates Indicate Mmentioning

confidence: 61%

Correlating Antimicrobial activity and Structure in Montmorillonite modified with Hexadecyltrimethylammonium and Silver

2018

IJCTR

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The relationship between antimicrobial properties and structure of montmorillonite (MMT) containing hexadecyltrimethylammonium bromide (HDTMA-Br) and silver (Ag) was determined. HDTMA was adsorbed at the clay interlayer by a cation exchange, through the positive head of the ammonium group. At higher surfactant loadings (100 and 200% cation exchange capacity (CEC); MH1 and MH2 samples, respectively) the prevalence of weak adsorption (Van der Waals forces) was observed; whereas below the clay CEC (50%, MH0.5) strong interactions predominated (cation exchange). These different interactions impacted on antimicrobial activity, increasing bactericidal capacity when the surfactant was more available to diffuse. For organo-montmorillonites (OMMT) and all samples with Ag, zeta potential pointed out electrical charge changes on the outer surface, respect to MMT. XPS analyses showed peaks attributed to clusters formation, silver oxidation, and Ag 0 in MMT-Ag and MH0.5-Ag. The Ag 0 peak was also present in MH1-Ag and MH2-Ag, the later showing an extra peak associated with AgBr. HDMTA + and Ag adsorbed on the MMT acted synergistically against Staphylococcus aureus. This effect was less noticeable for Escherichia coli and the result was attributed to both, E. coli outer envelope which might lower the efficacy of HDMTA + adsorbed on the MMT, and decreasing silver proportions when the surfactant loading increased. MH1-Ag presented the best bactericidal properties, showing synergistic effects against S. aureus, while maintaining activity against E. coli compared to MMT-Ag. Understanding MMT-HDMTA-Ag efficacy contributes to the design of new antimicrobial materials for potential applications in health care.

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In vitro assessment of Ag2O nanoparticles toxicity against Gram-positive and Gram-negative bacteria

Cited by 25 publications

References 25 publications

Predicting toxic potencies of metal oxide nanoparticles by means of nano-QSARs

Predicting toxic potencies of metal oxide nanoparticles by means of nano-QSARs

Synergistic evaluation of AgO₂nanoparticles with ceftriaxone against CTXM and blaSHV genes positive ESBL producing clinical strains of Uro‐pathogenicE. coli

Correlating Antimicrobial activity and Structure in Montmorillonite modified with Hexadecyltrimethylammonium and Silver

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In vitro assessment of Ag2O nanoparticles toxicity against Gram-positive and Gram-negative bacteria

Cited by 25 publications

References 25 publications

Predicting toxic potencies of metal oxide nanoparticles by means of nano-QSARs

Predicting toxic potencies of metal oxide nanoparticles by means of nano-QSARs

Synergistic evaluation of AgO2nanoparticles with ceftriaxone against CTXM and blaSHV genes positive ESBL producing clinical strains of Uro‐pathogenicE. coli

Correlating Antimicrobial activity and Structure in Montmorillonite modified with Hexadecyltrimethylammonium and Silver

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Synergistic evaluation of AgO₂nanoparticles with ceftriaxone against CTXM and blaSHV genes positive ESBL producing clinical strains of Uro‐pathogenicE. coli