In vitro assessment of the acaricidal activity of carvacrol, thymol, eugenol and their acetylated derivatives on Rhipicephalus microplus (Acari: Ixodidae)

Novato, Tatiane Pinheiro Lopes; Gomes, Geovany Amorim; Zeringóta, Viviane; Franco, Cristiane Teixeira; Oliveira, D. R. de; Melo, Diego; Carvalho, Mário Geraldo de; Daemon, Erik; Monteiro, Caio Márcio de Oliveira

doi:10.1016/j.vetpar.2018.07.009

Cited by 43 publications

(15 citation statements)

References 19 publications

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“…The larvicidal activity of EG alone against R. microplus (Araújo et al, 2016;Ferreira et al, 2018;Monteiro et al, 2012;Novato et al, 2018;Valente et al, 2014) and R. sanguineus (Araújo et al, 2016;Coelho et al, 2020;Senra et al, 2013) have already been described. The concentrations with which 100% mortality against R. microplus was achieved ranged from 3 mg.mL -1 (Valente et al, 2014) to 5 mg.mL -1 (Ferreira et al, 2018;Monteiro et al, 2012) and 15 mg.mL -1 (Novato et al, 2018).…”

Section: Discussionmentioning

confidence: 95%

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In vitro evaluation of the acaricidal activity of Syzygium aromaticum (L.) essential oil and eugenol against non-fed larvae of Rhipicephalus sanguineus

et al. 2021

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Section: Discussionmentioning

confidence: 95%

“…The LC 50 values ranged from 1.7 mg.mL -1 (Valente et al, 2014) to 2.77 mg.mL -1 (Novato et al, 2018) and 4.76 mg.mL -1 (Araújo et al, 2016). Mortality above 99% was reached at higher concentrations for R. sanguineus than for R. microplus (Araújo et al, 2016;Coelho et al, 2020;Senra et al, 2013).…”

Section: Discussionmentioning

confidence: 96%

In vitro evaluation of the acaricidal activity of Syzygium aromaticum (L.) essential oil and eugenol against non-fed larvae of Rhipicephalus sanguineus

et al. 2021

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“…Eugenol has also demonstrated antimicrobial and antioxidant activities [30], being also a powerful insecticide, effective on a wide variety of domestic arthropod pests [31][32][33]. A structural modification of EOs has been shown to enhance the biocidal effect of these phytochemicals by increasing their activity [34,35].…”

Section: Introductionmentioning

confidence: 99%

New Eugenol Derivatives with Enhanced Insecticidal Activity

Fernandes

Pereira

et al. 2020

IJMS

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Eugenol, the generic name of 4-allyl-2-methoxyphenol, is the major component of clove essential oil, and has demonstrated relevant biological potential with well-known antimicrobial and antioxidant actions. New O-alkylated eugenol derivatives, bearing a propyl chain with terminals like hydrogen, hydroxyl, ester, chlorine, and carboxylic acid, were synthesized in the present work. These compounds were later subjected to epoxidation conditions to give the corresponding oxiranes. All derivatives were evaluated against their effect upon the viability of insect cell line Sf9 (Spodoptera frugiperda), demonstrating that structural changes elicit marked effects in terms of potency. In addition, the most promising molecules were evaluated for their impact in cell morphology, caspase-like activity, and potential toxicity towards human cells. Some molecules stood out in terms of toxicity towards insect cells, with morphological assessment of treated cells showing chromatin condensation and fragmentation, which are compatible with the occurrence of programmed cell death, later confirmed by evaluation of caspase-like activity. These findings point out the potential use of eugenol derivatives as semisynthetic insecticides from plant natural products.

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“…Essential oils (EOs) exhibit antimicrobial activities with particular potential as insecticides [5]. Structural modifications in the constituents of EOs can further enhance their biocidal effect [2,4,6,7], being the best alternatives of synthetic chemicals and can be utilized as biopesticides or green pesticides [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Insecticidal Activity of O-alkylated Oxirane Eugenol Derivatives

Fernandes

Pereira

et al. 2020

The 24th International Electronic Conference on Synthetic Organic Chemistry

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The synthesis of three O-alkylated eugenol derivatives, bearing a hydroxypropyl chain and propyl esters were synthesised and further converted into the corresponding oxiranes. Oxirane derivatives were then evaluated against their effect upon the viability of the insect cell line Sf9 (Spodoptera frugiperda), in comparison with the starting O-alkylates. The results pointing to their potential as bioinsecticides, with structural changes eliciting significant effects in terms of potency.

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In vitro assessment of the acaricidal activity of carvacrol, thymol, eugenol and their acetylated derivatives on Rhipicephalus microplus (Acari: Ixodidae)

Cited by 43 publications

References 19 publications

In vitro evaluation of the acaricidal activity of Syzygium aromaticum (L.) essential oil and eugenol against non-fed larvae of Rhipicephalus sanguineus

In vitro evaluation of the acaricidal activity of Syzygium aromaticum (L.) essential oil and eugenol against non-fed larvae of Rhipicephalus sanguineus

New Eugenol Derivatives with Enhanced Insecticidal Activity

Synthesis and Insecticidal Activity of O-alkylated Oxirane Eugenol Derivatives

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