In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations

Krukiewicz, Katarzyna; Kowalik, Agnieszka; Turczyn, Roman; Biggs, Manus

doi:10.1016/j.bioelechem.2020.107528

Cited by 7 publications

(5 citation statements)

References 45 publications

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“…Capacitance was calculated based on the parameters of a constant phase element (CPE) as described previously. 42 CV curves were used to determine charge storage capacity (CSC) as described previously. 43 Transport properties of ITO/PET were evaluated with the use of a standard four-probe sensing method through the combination of a Keithley 220 current source and two Keithley 6512 electrometers.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…EIS Spectrum Analyzer 1.0 software and the Powell algorithm were used to fit the experimental data to an equivalent circuit model. Capacitance was calculated based on the parameters of a constant phase element (CPE) as described previously . CV curves were used to determine charge storage capacity (CSC) as described previously …”

Section: Materials and Methodsmentioning

confidence: 99%

Section: Materials and Methodsmentioning

confidence: 99%

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Flexible, Transparent, and Cytocompatible Nanostructured Indium Tin Oxide Thin Films for Bio-optoelectronic Applications

Krukiewicz,

Czerwińska-Główka,

Turczyn

et al. 2023

ACS Appl. Mater. Interfaces

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Electrical stimulation has been used successfully for several decades for the treatment of neurodegenerative disorders, including motor disorders, pain, and psychiatric disorders. These technologies typically rely on the modulation of neural activity through the focused delivery of electrical pulses. Recent research, however, has shown that electrically triggered neuromodulation can be further enhanced when coupled with optical stimulation, an approach that can benefit from the development of novel electrode materials that combine transparency with excellent electrochemical and biological performance. In this study, we describe an electrochemically modified, nanostructured indium tin oxide/poly(ethylene terephthalate) (ITO/PET) surface as a flexible, transparent, and cytocompatible electrode material. Electrochemical oxidation and reduction of ITO/PET electrodes in the presence of an ionic liquid based on D-glucopyranoside and bistriflamide units were performed, and the electrochemical behavior, conductivity, capacitance, charge transport processes, surface morphology, optical properties, and cytocompatibility were assessed in vitro. It has been shown that under selected conditions, electrochemically modified ITO/PET films remained transparent and highly conductive and were able to enhance neural cell survival and neurite outgrowth. Consequently, electrochemical modification of ITO/PET electrodes in the presence of an ionic liquid is introduced as an effective approach for tailoring the properties of ITO for advanced bio-optoelectronic applications.

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Section: ■ Materials and Methodsmentioning

confidence: 99%

Section: Materials and Methodsmentioning

confidence: 99%

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Flexible, Transparent, and Cytocompatible Nanostructured Indium Tin Oxide Thin Films for Bio-optoelectronic Applications

Krukiewicz,

Czerwińska-Główka,

Turczyn

et al. 2023

ACS Appl. Mater. Interfaces

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“…These devices have been extensively reviewed elsewhere 42 − 45 and have been utilized in a variety of recent in vitro neuromodulation demonstrations. 46 − 52 However, such controlled delivery electrodes have seen few neuromodulation demonstrations in vivo .…”

Section: Chemical Stimulation and Drug Deliverymentioning

confidence: 99%

“…Over the decades, a variety of such controlled delivery electrodes have been demonstrated, all following the basic recipe of embedding bioactive substances in the redox-active conducting polymer film (as counterions in the PPy example above, or co-ions compensating the counterions) and releasing them into the adjacent electrolyte upon redox switching (Figure a). These devices have been extensively reviewed elsewhere − and have been utilized in a variety of recent in vitro neuromodulation demonstrations. − However, such controlled delivery electrodes have seen few neuromodulation demonstrations in vivo .…”

Section: Chemical Stimulation and Drug Deliverymentioning

confidence: 99%

In Vivo Organic Bioelectronics for Neuromodulation

et al. 2022

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The nervous system poses a grand challenge for integration with modern electronics and the subsequent advances in neurobiology, neuroprosthetics, and therapy which would become possible upon such integration. Due to its extreme complexity, multifaceted signaling pathways, and ∼1 kHz operating frequency, modern complementary metal oxide semiconductor (CMOS) based electronics appear to be the only technology platform at hand for such integration. However, conventional CMOS-based electronics rely exclusively on electronic signaling and therefore require an additional technology platform to translate electronic signals into the language of neurobiology. Organic electronics are just such a technology platform, capable of converting electronic addressing into a variety of signals matching the endogenous signaling of the nervous system while simultaneously possessing favorable material similarities with nervous tissue. In this review, we introduce a variety of organic material platforms and signaling modalities specifically designed for this role as “translator”, focusing especially on recent implementation in in vivo neuromodulation. We hope that this review serves both as an informational resource and as an encouragement and challenge to the field.

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Rivastigmine Reverses the Decrease in Synapsin and Memory Caused by Homocysteine: Is There Relation to Inflammation?

et al. 2022

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In vitro attenuation of astrocyte activation and neuroinflammation through ibuprofen-doping of poly(3,4-ethylenedioxypyrrole) formulations

Cited by 7 publications

References 45 publications

Flexible, Transparent, and Cytocompatible Nanostructured Indium Tin Oxide Thin Films for Bio-optoelectronic Applications

Flexible, Transparent, and Cytocompatible Nanostructured Indium Tin Oxide Thin Films for Bio-optoelectronic Applications

In Vivo Organic Bioelectronics for Neuromodulation

Rivastigmine Reverses the Decrease in Synapsin and Memory Caused by Homocysteine: Is There Relation to Inflammation?

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