In vitro bioactivity assessment and mechanical properties of novel calcium titanate/borosilicate glass composites

Villalpando-Reyna, Angel F.; Cortés-Hernández, Dora A.; Gorokhovsky, Alexander; Almanza-Robles, J.M.; Escobedo‐Bocardo, José C.

doi:10.1016/j.ceramint.2011.01.034

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…The results obtained indicate that the mechan- ical properties of these composites are similar or even higher than those of some existing bioactive systems (5 to 20 MPa) [33]. Although compressive strength of these materials is lower than that of the calcium titanate/borosilicate glass composites reported earlier in our previous work [26], the potential toxic effects due to the presence of boron in the apatite layer is avoided.…”

Section: Resultssupporting

confidence: 51%

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Development of bioactive and biocompatible ceramic composites based on potassium polytitanate

Villalpando-Reyna

Cortés-Hernández

Granjeiro

et al. 2019

PAC

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Bioactive and biocompatible composites were successfully prepared by reactive sintering of mixtures of a crystalline titanate precursor and 45S5 Bioglass ® . The polytitanate/glass precursor ratios were 20/80, 40/60, 60/40 or 80/20 (wt.%). The powder mixtures were uniaxially pressed and heat treated at 1000°C for 1 h. During sintering, intensive interactions between raw materials occurred. The formed main crystalline phases were: potassium hexatitanate (K 2 Ti 6 O 13 ), calcium titanate (CaTiO 3 ), calcium silicate (CaSiO 4 ) and sodium-calcium silicate (Na 6 Ca 3 Si 6 O 18 ). Additionally, a Si-rich glassy phase was also observed. The mechanism of apatite formation indicated that both crystalline and amorphous phases play important roles in this process. A homogeneous apatite layer was formed on Si-OH, Ti-OH-rich interfaces. In vitro bioactivity was assessed using simulated body fluid (SBF K-9). The in vitro cytotoxicity behaviour was evaluated using a human osteoblastlike cells model and compressive strength by ASTM C-773 standard. All the composites demonstrated high bioactivity as cytotoxicity assays indicated a biocompatibility similar to that of the negative control. The samples showed high cell adherence and elongation cell characteristics similar to those observed on biocompatible systems. The compressive strength of the sintered samples decreased as the polytitanate content precursor was increased. The results obtained indicate that these materials are highly promising composites for medical applications.

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Section: Resultssupporting

confidence: 51%

“…In our previous work [26], mixtures of potassium polytitanate powder (10-30 wt.%) with powdered calcium-borate glass were prepared in order to obtain bioactive composites with improved mechanical properties by sintering at 800-900°C. However, a relatively high release of boron to the simulated body fluid (SBF) was observed.…”

Section: Introductionmentioning

confidence: 99%

Development of bioactive and biocompatible ceramic composites based on potassium polytitanate

Villalpando-Reyna

Cortés-Hernández

Granjeiro

et al. 2019

PAC

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“…It has been reported that potassium titanates are biocompatible, and potassium titanate nanorod arrays can induce the formation of apatite after 4 days in SBF (simulated body fluid) solution. The bioactive PHT whiskers have good biocompatibility and are potential candidates as reinforcing agents to improve the mechanical properties of calcium phosphate ceramics or cements, in order to apply them in load conditions [99][100][101][102]. Another application was established by Gonzáles-Lozano et al [103].…”

Section: Other Applicationsmentioning

confidence: 99%

Crystalline Structure, Synthesis, Properties and Applications of Potassium Hexatitanate: A Review

et al. 2019

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Potassium hexatitanate (PHT) with chemical formula K2Ti6O13 has a tunnel structure formed by TiO2 octahedra sharing edges or corners and with the potassium atoms located in the tunnels. This material has attracted great interest in the areas of photocatalysis, reinforcement of materials, biomaterials, etc. This work summarizes a large number of studies about methods to prepare PHT since particle size can be modified from millimeter to nanometric scale according to the applied method. Likewise, the synthesis method has influenced the material properties as band-gap and the final mechanical performance of composites when the reinforcement is PHT. The knowing of synthesis, properties and applications of PHT is worthwhile for the design of new materials and for the development of new applications taking advantage of their inherent properties.

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“…In vitro bioactivity test was assessed by exposing the modified glass samples to the simulated body fluid (SBF) performed according to the recipe reported by Kokubo et al [17,18] and remembered in the numerous published articles, for example Ref. [19,20]. SBF is an acellular aqueous medium with inorganic ion composition nearly similar to that of the human blood plasma.…”

Section: Glass-derived Scaffoldmentioning

confidence: 99%

“…SBF solution was prepared by mixing the appropriate amounts of sodium chloride (NaCl), sodium hydrogen carbonate (NaHCO 3 ), potassium chloride (KCl), di-potassium hydrogen phosphate trihydrate (K 2 HPO 4 ·3H 2 O) and magnesium chloride hexahydrate (MgCl 2 · 6H 2 O), calcium chloride (CaCl 2 ), sodium sulfate (Na 2 SO 4 ) in deionized water with the help of magnetic stirrer in a beaker, according to the concentrations given in Ref. [17][18][19][20]. Then, the solution was buffered to pH = 7.4 with tris-hydroxymethyl-amino-methane [(CH 2 OH) 3 CNH 3 ] and one molar-hydrochloric acid (1M-HCl).…”

Section: Glass-derived Scaffoldmentioning

confidence: 99%

Synthesis of borate modified bioactive glass scaffold using PVP burning-out method for bone tissue replacement

2019

Biointerface Res Appl Chem

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Three-dimensional (3D) bioactive glass scaffolds are one of the most studied types of scaffolds for bone tissue replacement because of their excellent bioactivity and potential for stimulating osteogenesis and angiogenesis. In the present study, modified Hench- based bioglass was fabricated by polyvinyl pyrrolidone (PVP) burning-out method for producing porous scaffold. In vitro investigation of the scaffolds’ bioactivity was achieved through examining changes in its composition during exposing to physiological simulated body fluid (SBF) solution via Fourier transform-infrared (FT-IR) absorption spectroscopy, X-ray diffraction (XRD) analysis, Scanning electron microscopy (SEM) supported by Energy-dispersive X-ray (EDX). FT-IR spectral data was used to validate the formation of hydroxyapatite as an indication of the bioactivity potential of the studied scaffold post incubation in SBF. The prepared samples were examined by XRD to recognize the crystalline phase/phases that may formed after immersion in physiological solutions and supported via (SEM/EDX) data.

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In vitro bioactivity assessment and mechanical properties of novel calcium titanate/borosilicate glass composites

Cited by 8 publications

References 19 publications

Development of bioactive and biocompatible ceramic composites based on potassium polytitanate

Development of bioactive and biocompatible ceramic composites based on potassium polytitanate

Crystalline Structure, Synthesis, Properties and Applications of Potassium Hexatitanate: A Review

Synthesis of borate modified bioactive glass scaffold using PVP burning-out method for bone tissue replacement

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