In Vitro Bioactivity Test of Senna Alata (L.) Roxb Leaves Extract

Rahmawati, Fri; Prihantini, Nur Nunu; Hady, Bella Christina

doi:10.52403/ijhsr.20220241

Cited by 3 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are also prepared as a paste and applied topically to manage various skin disorders, such as AD, ringworm, and white-spot fungal infections [ 13 , 14 , 15 ]. The phytochemical ingredients in C. alata flower and leaves could exhibit promising antifungal and wound healing properties [ 13 , 16 , 17 , 18 , 19 ]. C. alata consists of various phytochemicals, including alkaloids, tannins, saponins, phenols, flavonoids, anthraquinones, and cardiac glycosides [ 20 , 21 , 22 ].…”

Section: Cassia Alata L (Caesalpinaceae)mentioning

confidence: 99%

Cassia alata, Coriandrum sativum, Curcuma longa and Azadirachta indica: Food Ingredients as Complementary and Alternative Therapies for Atopic Dermatitis-A Comprehensive Review

et al. 2022

View full text Add to dashboard Cite

Traditional medicine is critical in disease treatment and management. Herbs are gaining popularity for disease management and treatment. Therefore, they can be utilised as complementary and alternative treatment (CAT) ingredients. Atopic dermatitis (AD) is one of the common non-communicable diseases. It is characterised by chronic inflammatory skin disease with intense pruritus and eczematous lesions. AD is associated with oxidative stress, microbial infection, and upregulation of inflammatory cytokines. Both children and adults could be affected by this skin disorder. The prevalence of AD is increasing along with the country’s level of development. This review revisited the literature on four medicinal herbs widely used as complementary medicine to manage AD. These therapeutic herbs are commonly eaten as food and used as spices in Asian cuisine. The four food herbs reviewed are Cassia alata, Coriandrum sativum, Curcuma longa Linn, and Azadirachta indica. Their traditional uses and phytochemical content will be covered. Four relevant pharmacological and biological activities of the plants crucial in AD management have been reviewed and discussed, including anti-inflammatory, anti-microbial, antioxidant, and wound recovery.

show abstract

Section: Cassia Alata L (Caesalpinaceae)mentioning

confidence: 99%

Cassia alata, Coriandrum sativum, Curcuma longa and Azadirachta indica: Food Ingredients as Complementary and Alternative Therapies for Atopic Dermatitis-A Comprehensive Review

et al. 2022

View full text Add to dashboard Cite

show abstract

In vitro and in silico studies of antibacterial activities of secofriedelane derivatives from Senna alata (L) Roxb

Chimi,

Ewonkem,

Tiakouang

et al. 2023

Natural Product Research

View full text Add to dashboard Cite

In this study, six compounds were obtained from a methanolic extract of air-dried leaves of Senna alata and one of them, a triterpenoid (secofriedelane) named as 7-(2-carboxyethyl)-3, 4b, 6a, 8, 10a, 12a-hexamethyl-8-vinyloctadecahydrochrysene-3-carboxylic acid (5) was isolated for the first time from this plant. Then, its chemical structure was detailed and characterized by FT-IR, 1 H and 13 C-NMR and ESI-MS. Besides, two chemical-modified derivatives of secofriedelane (5a, 5b) were synthesized by methylation and allylation reactions, respectively, and their in vitro antibacterial activities were also evaluated. The results revealed that all the triterpenes showed, against gram-positive and -negative bacterial strains, good and moderate antibacterial activities with bactericidal effects that were enhanced by the methyl groups and altered with the allyl ones. Moreover, the molecular docking results of 5, 5a and 5b in the DNA gyrase (2XCT) active site showed that triterpene 5 has a good score very close to reference (ciprofloxacin).

show abstract

Review on Cassia alata Bioactive Compounds: In silico, in vitro, and in vivo Studies

Colin,

Claudiana,

Kaffah

et al. 2024

DDDT

View full text Add to dashboard Cite

Cassia alata Linn is a popular herbal remedy in many countries, and its activities have been studied through many studies, starting from in silico, in vitro, and in vivo. This narrative review will focus more on secondary metabolites that are responsible for certain pharmacological activities that have undergone in vivo, in vitro, and in silico testing to determine the underlying mechanism. Twenty pharmacological activities have been identified, with the flavonoid group (emodin, kaempferol, quercetin) as the most prevalent secondary metabolite found in Cassia alata . There have been numerous studies looking at the role of flavonoids about specific diseases, and flavonoid testing is quite thorough because it covers three different study types. However, there has not been significant progress accomplished in terms of the evaluation of the dosage form so that test results for promising activities like antidiabetic, antifungal, and antiviral can be carried out into further research. Additionally, several disorders lack comprehensive investigation, particularly in silico studies, therefore further study is required to fill any gaps in the knowledge.

show abstract

In Vitro Bioactivity Test of Senna Alata (L.) Roxb Leaves Extract

Cited by 3 publications

References 17 publications

Cassia alata, Coriandrum sativum, Curcuma longa and Azadirachta indica: Food Ingredients as Complementary and Alternative Therapies for Atopic Dermatitis-A Comprehensive Review

Cassia alata, Coriandrum sativum, Curcuma longa and Azadirachta indica: Food Ingredients as Complementary and Alternative Therapies for Atopic Dermatitis-A Comprehensive Review

In vitro and in silico studies of antibacterial activities of secofriedelane derivatives from Senna alata (L) Roxb

Review on Cassia alata Bioactive Compounds: In silico, in vitro, and in vivo Studies

Contact Info

Product

Resources

About