In vitro biocompatibility and corrosion resistance of a new implant titanium base alloy

Abstract

One objective of this work was to study the corrosion resistance of the new implant Ti-10Zr-5Ta-5Nb alloy in physiological fluids of different pH values, simulating the extreme functional conditions. Another objective was in vitro biocompatibility evaluation of the new alloy using human fetal osteoblast cell line hFOB 1.19. Cytocompatibility was assessed by determination of possible material cytotoxic effects, cell morphology and cell adhesion. The thermo-mechanical processing of the new implant alloy consisted in plastic deformation (almost 90%) performed by hot rolling accompanied by an initial and final heat treatment. The new Ti-10Zr-5Ta-5Nb alloy presented self-passivation, with a large passive potential range and low passive current densities, namely, a very good anticorrosive resistance in Ringer solution of acid, neutral and alkaline pH values. Cell viability was not affected by the alloy substrate presence and a very good compatibility was noticed.

Bone response to a novel Ti–Ta–Nb–Zr alloy

“…A difference in bone formation around implants of pure Ti, hafnium (Hf), rhenium (Re), Nb and Ta in vivo using a rat model has been shown, where greater bone area was observed for Nb, Ta and Re as compared to Ti after 4 weeks [19]. The biocompatibility of Ti, Zr, Nb and Ta is well documented in the literature [18][19][20] and in agreement with the results of the present study where neither the Ti nor the Ti-Ta-Nb-Zr material showed any sign of cytotoxicity or adverse tissue reactions. The metal release of Zr-Nb-Ta-alloyed Ti compared with that of Ti-Al-V has been evaluated both in vitro [53] and in a rat model up to 48 weeks in vivo [54], showing very low metal release for the Ti-, Zr-, Nb-and Ta-containing material, indicating that it may be advantageous for long-term implantation.…”

“…Significantly higher bone-implant contact was also observed for Ti and Ta as compared to the other metals at 4 weeks [19]. A binary alloy consisting of Ti and 8 at% Zr is in clinical use and has shown good biocompatibility [20] and osseointegration [21]. This alloy performed in a similar manner to Ti in vitro, in vivo and clinically, but long-term clinical evaluation is yet lacking [22].…”

Surface characterisation and electrochemical stability of anodised new alloy in simulated physiological electrolytes

“…The spectra were acquired in the 10 5 -10 À1 Hz frequency range. The impedance spectra were displayed as Nyquist and Bode (phase angle vs. frequency) diagrams [29][30][31][32].…”

“…VoltaMaster 4 program directly supplies the values of the corrosion current density, i corr , corrosion rate, V corr and polarisation resistance, R p . Ion release rates were calculated [29][30][31][32].…”

Surface Modification of Titanium and its Alloys for the Enhancement of Osseointegration in Orthopaedics

“…Ti-10Zr-5Ta-5Nb alloy was modified by hot rolling accompanied with heat treatment and the biocompatibility of modified surface was examined. The results suggested that there is no effect on cell viability of human fetal osteoblast cell line hFOB 1.19 and the corrosion resistance was improved with increased biocompatibility 69 . The surface morphology of alkali-heat treated Ti-27Nb alloy was characterized via SEM, XRD.…”