In vitro biocompatibility testing of polymers for orthopaedic implants using cultured fibroblasts and osteoblasts

Morrison, Christopher A.; Macnair, R.; MacDonald, Caroline; Wykman, Anders; Goldie, Ian; Grant, M.H.

doi:10.1016/0142-9612(95)94906-2

Cited by 234 publications

(128 citation statements)

References 15 publications

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“…Grafts adapted to fit a round implant surface should provide a firmer and more secure attachment 2) . Polymers have attracted significant attention as substitutes for metal alloys in orthopedic applications [3][4][5][6][7] . Polyetheretherketone (PEEK) is widely used as a structural polymer for numerous applications in orthopedics and dentistry 5,[8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

<i>In vivo</i> bioactivity of porous polyetheretherketone with a foamed surface

Hieda

Uemura

Hashimoto

et al. 2017

Dental Materials Journal

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The in vivo bioactivity of porous polyetheretherketone (PEEK) with a foamed surface was evaluated using rabbit femoral bone. Cylindrical porous PEEK scaffolds, with pore diameter of 550 μm and porosity of 70%, were first prepared and immersed in 98% sulfuric acid, and then washed and immersed in 3 M potassium carbonate solution used as a foaming reagent. Numerous open pores of various sizes, as well as new functional groups, were visualized on the treated PEEK surface by scanning electron microscopy and X-ray photoelectron spectroscopy, respectively. Micro computed tomography (micro-CT) showed that the volumetric density of treated PEEK was higher than that of bare PEEK at 8 weeks after surgery (p<0.05). Additionally, von Kossa staining indicated ingrowth of mature new bone tissue at 4 weeks relative to the bare PEEK group. Our data indicate that surface-treated PEEK exhibited improved bioactivity in vivo.

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Section: Introductionmentioning

confidence: 99%

<i>In vivo</i> bioactivity of porous polyetheretherketone with a foamed surface

Hieda

Uemura

Hashimoto

et al. 2017

Dental Materials Journal

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“…7,8 However, PEEK has shown both in vivo and in vitro studies to have low bioactive features due to the relatively bioinert surface. [9][10][11] Therefore, many studies have been conducted to improve the biocompatible state of PEEK by incorporating bioactive substances into the substrate or onto the surface as a coating. [12][13][14] The authors have…”

Section: Introductionmentioning

confidence: 99%

“…In other studies, this exceptional technique has been found to successfully increase the bone formation on titanium but it has never been applied on PEEK. [9][10][11][12][13][14][15][16][17][18][19][20][21] Using HA in the form of nanoparticles increases not only the surface area but also the interaction and adhesion between the crystals and the PEEK surface. Another unique feature of this study was a perforating hole of the implant that permits evaluation of the osteoconductive effect of the surface modification.…”

mentioning

confidence: 99%

Polyether ether ketone implants achieve increased bone fusion when coated with nano-sized hydroxyapatite: a histomorphometric study in rabbit bone

Johansson¹,

Jimbo²,

Naito³

et al. 2016

IJN

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Polyether ether ketone (PEEK) possesses excellent mechanical properties similar to those of human bone and is considered the best alternative material other than titanium for orthopedic spine and trauma implants. However, the deficient osteogenic properties and the bioinertness of PEEK limit its fields of application. The aim of this study was to limit these drawbacks by coating the surface of PEEK with nano-scaled hydroxyapatite (HA) minerals. In the study, the biological response to PEEK, with and without HA coating, was investigated. Twenty-four screw-like and apically perforated implants in the rabbit femur were histologically evaluated at 3 weeks and 12 weeks after surgery. Twelve of the 24 implants were HA coated (test), and the remaining 12 served as uncoated PEEK controls. At 3 weeks and 12 weeks, the mean bone–implant contact was higher for test compared to control ( P <0.05). The bone area inside the threads was comparable in the two groups, but the perforating hole showed more bone area for the HA-coated implants at both healing points ( P <0.01). With these results, we conclude that nano-sized HA coating on PEEK implants significantly improved the osteogenic properties, and in a clinical situation this material composition may serve as an implant where a rapid bone fusion is essential.

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“…There is an internal titanium screw for initial fixation and the stems are coated with titanium for bone ingrowth [24]. PEEK has been proven to be a biocompatible biomaterial and with sufficient strength for a joint replacement [25]. One retrospective study that compared the outcome of 86 silicone implants versus 22 RM prostheses for the MCPJs and PIPJs in a short to medium follow-up has been demonstrated a significant higher functionality and stability of the RM prostheses versus the silicone implants [10].…”

Section: Discussionmentioning

confidence: 99%

A 10-Year Follow-Up of Uncemented Constrained Metacarpophalangeal Joint Arthroplasties Using the RM Prosthesis in a Patient with Rheumatoid Arthritis.

Schmidt¹

2017

JRAD

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A 72-year-old male with high-demand activities of daily living presented with rheumatoid arthritis mostly affected finger joints of his right hand. Radiographically, there was severe destruction with luxation of metacarpophalangeal joints (MCPJs) II-V. The constrained RM prostheses were inserted into the MCPJs II-V typically in the uncemented manner, and the course was primarily complicated due to periprosthetic fracture of the metacarpal IV intraoperatively, that was treated with immobilization in a plaster splint for 6 weeks. After that, the course was uncomplicated. Eight years after primary surgery, the patient reported increasing pain with loss of function isolated in his MCPJ IV since 6 months; all other finger joints did not reveal any clinically relevant symptoms. Radiographically, distinctive osteolyses with cortical thinning around all components of the 4 RM prostheses were seen, and the hinge joint of implant in MCPJ IV was broken. A total exchange arthroplasty of the MCPJ IV using the unconstrained MCPJ resurfacing SR TM MCP implant with cementation of both components was performed. At the 10-year follow-up, that includes a 2-year followup after MCPJ IV exchange arthroplasty, there was unchanged correct positioning of all MCPJ implants; and despite distinctive radiographic loosening and subsidence of the 3 other RM prostheses, the patient is able to perform his high-demand activities of daily living.

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In vitro biocompatibility testing of polymers for orthopaedic implants using cultured fibroblasts and osteoblasts

Cited by 234 publications

References 15 publications

<i>In vivo</i> bioactivity of porous polyetheretherketone with a foamed surface

<i>In vivo</i> bioactivity of porous polyetheretherketone with a foamed surface

Polyether ether ketone implants achieve increased bone fusion when coated with nano-sized hydroxyapatite: a histomorphometric study in rabbit bone

A 10-Year Follow-Up of Uncemented Constrained Metacarpophalangeal Joint Arthroplasties Using the RM Prosthesis in a Patient with Rheumatoid Arthritis.

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