In vitro Biological Activity of Salvia leriifolia Benth Essential Oil Relevant to the Treatment of Alzheimer's Disease

Abstract

In this study the chemical composition, cholinesterase inhibitory property and antiinflammatory activity of S. leriifolia Benth. essential oil was evaluated for the first time. GC and GC-MS analysis revealed the presence of camphor (10.5%), 1,8-cineole (8.6%), camphene (6.2%) and a-pinene (4.7%) as main constituents. S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC 50 2.26 mL/mL. Interesting cholinesterase inhibitory activity was also found with IC 50 values of 0.32 and 0.29 mL/mL for acetylcholinesterase (AChE) and butyrrylcholinesterase (BChE), respectively. Moreover, this oil inhibited LPS-induced NO production with an IC 50 value of 165 mg/mL. The absence of cytotoxicity at 1000 mg/mL was evaluated by MTT assay in 142BR cells.

Acetylcholinesterase and butyrylcholinesterase inhibitory activity of Pinus species essential oils and their constituents

“…The effects of Salvia lavandulaefolia essential oil and some of its constituents 16,17 . In our previous investigations, the inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by S. leriifolia, Origanum ehrenbergii, and O. syriacum essential oils was reported [18][19][20] . Various essential oil components have been investigated for their effects on AChE.…”

“…Due to their small molecular size and lipophilicity, volatile constituents of essential oils are likely to readily cross the blood-brain barrier 24 . As a part of our efforts to find new anti-cholinesterase active compounds [18][19][20]25 , in this study we aimed to evaluate the AChE and BChE inhibitory activity of essential oils from three Pinus species, i.e. Pinus nigra subsp.…”

essential oil (EO) composition and antioxidant activity of two Salvia leriifolia Benth. (Lamiaceae) populations from Iran

“…The constituents of the EO's were listed in (Monfared & Ghorbanli, 2009). According to another study carried out by Loizzo et al (2009), camphor (10.5%), 1, 8-cineol (8.6%), camphene (6.2%) and α-pinene (4.7%) were the main components of S. leriifolia EO from the southern regions of Khorassan (Loizzo et al, 2009).…”

“…According to a study executed by Loizzo et al (2009), S. leriifolia oil exhibited a promising antioxidant activity by DPPH assay with an IC 50 2.26 μl/ml. a RI: The retention index calculated from retention times relative to C8-C20 n-alkanes on a CP-Sil 8 CB column.…”

“…Little information is available on the antioxidative nature of its EO for treatment of Alzheimer and acetyl-cholinesterase inhibitory. This plant has been introduced as an herbal medicine in toxicological and clinical trial evaluations (Hosseinzadeh et al, 2009;Savelev et al, 2004;Loizzo et al, 2009). An attempt was made in this study to identify the composition and to examine the antioxidant activity of S. leriifolia EOs in its flowering stage.…”