In vitro biological activity of resveratrol using a novel inhalable resveratrol spray-dried formulation

Trotta, Valentina; Lee, Wing-Hin; Loo, Ching-Yee; Haghi, Mehra; Young, Paul M.; Scalia, Santo; Traini, Daniela

doi:10.1016/j.ijpharm.2015.06.033

Cited by 35 publications

(24 citation statements)

References 52 publications

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“…Resveratrol (trans-3,5,4′-trihydroxystilbene), a phytoalexin that functions to protect plants from parasites or environmental stress (30), is a polyphenolic compound present in grapes, peanuts, berries and wine. A number of studies have reported that resveratrol possesses a wide variety of health-promoting properties, including anticancer, anti-inflammatory, antimicrobial, cardioprotective and antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity

Cui¹,

Xuan

Wu³

et al. 2016

Molecular Medicine Reports

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Male infertility is a complex, multifactorial and polygenic disease that contributes to ~50% cases of infertility. Previous studies have demonstrated that excess weight and obesity factors serve an important role in the development of male infertility. An increasing number of studies have reported that resveratrol may regulate the response of cells to specific stimuli that induce cell injury, as well as decrease germ cell apoptosis in mice or rats. In the present study, the semen quality and serum sex hormone levels were evaluated in 324 men, which included 73 underweight, 82 normal weight, 95 overweight and 74 obese men. All patients were referred to The Reproductive Medicine Center of Shanxi Women and Infants Hospital (Taiyuan, China) between January 2013 and January 2015. The aim of the present study was to investigate the effects of resveratrol treatment on the motility, plasma zinc concentration and acrosin activity of sperm from obese males. The sperm concentration, normal sperm morphology, semen volumes, DNA fragmentation rates and testosterone levels in men from the overweight and obese groups were markedly decreased when compared with men in the normal weight group. In addition, the progressive motility, seminal plasma zinc concentration and spermatozoa acrosin activity were notably decreased in the obese group compared with the normal weight group. However, estradiol levels were significantly increased in the overweight, obese and underweight groups compared with the normal weight group. Notably, semen samples from obese males with astenospermia treated with 0–100 µmol/l resveratrol for 30 min demonstrated varying degrees of improvement in sperm motility. When these semen samples were treated with 30 µmol/l resveratrol, sperm motility improved when compared to other doses of resveratrol. Therefore, 30 µmol/l resveratrol was selected for further experiments. Upon treatment of semen samples with resveratrol (30 µmol/l) for 30 min, the seminal plasma zinc concentration and spermatozoa acrosin activity increased significantly in the experimental group compared with the control group. These data suggest that male obesity negatively impacts on male reproductive potential, not only through altering hormone levels, but also by directly altering sperm function. In addition, resveratrol may have a therapeutic and protective effect against obesity-induced abnormalities in semen.

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Section: Discussionmentioning

confidence: 99%

Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity

Cui¹,

Xuan

Wu³

et al. 2016

Molecular Medicine Reports

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“…A novel inhalable spray-dried formulation of RES could be an effective future candidate in the treatment of COPD (Trotta et al, 2015). Trotta et al (2015) developed a formulation that met all criteria (particular size, mass median aerodynamic diameter, geometric standard deviation, total recovery of loaded dose, sufficient aerosol performance, stability, absorption and rate of transport) for administration to the lung epithelium. By utilising the inhalable route of administration, the hope is that the concentration of RES will be maximised in the lungs, where it can elicit its biological effect.…”

Section: Alternative Routes Of Administrationmentioning

confidence: 99%

Bioavailability of resveratrol: Possibilities for enhancement

Vries

Strydom²,

Steenkamp

2018

Journal of Herbal Medicine

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“…Based on this evidence, we developed an aerosol formulation for inhalation to reach the bronchial epithelia for the optimal anti-inflammatory and antiviral targeted activity. On this topic, a recent paper reported on the preparation of resveratrol as a dry powder for inhalation for the treatment of inflammatory lung diseases [22]. In this paper, we present evidence that the resveratrol/CM-glucan combination may be suitable for the administration via inhalation, suggesting that it could be useful in lower respiratory tract infections, COPD, and asthma.…”

Section: Introductionmentioning

confidence: 74%

Studies on Trans-Resveratrol/Carboxymethylated (1,3/1,6)-β-d-Glucan Association for Aerosol Pharmaceutical Applications

Francioso

Cossi²,

Fanelli

et al. 2017

IJMS

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A resveratrol/carboxymethylated glucan (CM-glucan) combination is known to inhibit rhinovirus replication and expression of inflammatory mediators in nasal epithelia. The aim of this study was to develop an aerosol formulation containing an association of the two molecules which could reach the lower respiratory tract. Mass median aerodynamic diameter (MMAD) of a resveratrol/CM-glucan combination was lower than that shown by resveratrol or CM-glucan alone (2.83 versus 3.28 and 2.96 µm, respectively). The resveratrol/CM-glucan association results in the finest and most monodispersed particles in comparison to the two single components. The association also evidenced lower values for all particle size distribution parameters, suggesting that the pharmacological synergy observed in previous studies may be accompanied by a pharmaceutical one. Moreover, we showed that the CM-glucan matrix did not exert an inhibitory effect on resveratrol nebulization, demonstrating the good suitability of these two molecules in association for simultaneous aerosol volatilization.

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In vitro biological activity of resveratrol using a novel inhalable resveratrol spray-dried formulation

Cited by 35 publications

References 52 publications

Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity

Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity

Bioavailability of resveratrol: Possibilities for enhancement

Studies on Trans-Resveratrol/Carboxymethylated (1,3/1,6)-β-d-Glucan Association for Aerosol Pharmaceutical Applications

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