In vitro biological evaluation of high molecular weight hyperbranched polyglycerols

Kainthan, Rajesh K.; Hester, Samuel R.; Levin, E.J.; Devine, Dana V.; Brooks, Donald E.

doi:10.1016/j.biomaterials.2007.07.011

Cited by 238 publications

(198 citation statements)

References 56 publications

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“…In preliminary cell culture experiments, hyperbranched PG with a molecular weight of 5 kDa showed absolutely no toxicity at cellular level. [113] Brooks and coworkers [138][139][140][141] reported several studies including a comprehensive analysis of PGs in a broad MW distribution and with different compositions. Both linear and hyperbranched PGs were reported to have a similar or even better biocompatibility profile than PEG with MW ranging from 4.2 to 670 kDa.…”

Section: Biocompatibility Profile Of Dendritic Polyglycerolsmentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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The application of nanotechnology in medicine and pharmaceuticals is a rapidly advancing field that is quickly gaining acceptance and recognition as an independent area of research called "nanomedicine". Urgent needs in this field, however, are biocompatible and bioactive materials for antifouling surfaces and nanoparticles for drug delivery. Therefore, extensive attention has been given to the design and development of new macromolecular structures. Among the various polymeric architectures, dendritic ("treelike") polymers have experienced an exponential development due to their highly branched, multifunctional, and well-defined structures. This Review describes the diverse syntheses and biomedical applications of dendritic polyglycerols (PGs). These polymers exhibit good chemical stability and inertness under biological conditions and are highly biocompatible. Oligoglycerols and their fatty acid esters are FDA-approved and are already being used in a variety of consumer applications, e.g., cosmetics and toiletries, food industries, cleaning and softening agents, pharmaceuticals, polymers and polymer additives, printing photographing materials, and electronics. Herein, we present the current status of dendritic PGs as functional dendritic architectures with particular focus on their application in nanomedicine, in drug, dye, and gene delivery, as well as in regenerative medicine in the form of non-fouling surfaces and matrix materials.

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Section: Biocompatibility Profile Of Dendritic Polyglycerolsmentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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“…HPGs weisen eine hohe Biokompatibilität auf und wurden mit Molgewichten bis zu M n % 1 MDa (Durchmesser % 10 nm), enger Polydispersität und guter Löslichkeit in polaren Lösungsmitteln hergestellt. [5] Makrogele auf HPG-Basis wurden bereits für den Transport von Wirkstoffen und für die Gewebezüchtung (Tissue Engineering) entwickelt. [6] Bislang gibt es jedoch noch keine effiziente Syntheseroute zu biokompatiblen und wasserlöslichen Mikrogelen im Nanometerbereich (10-200 nm).…”

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Biokompatible funktionalisierte zellgängige Polyglycerinmikrogele

et al. 2009

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Gel für die Zelle: Eine neue Methode zur Herstellung biokompatibler Polyglycerinmikrogele mit einstellbaren Größen (25–100 nm; oben im Bild) und Oberflächenfunktionalisierung (rote Kugeln) wurde entwickelt. Fluoreszenzmikroskopische Messungen belegen, dass die Partikel durch endocytotische Mechanismen in die Zellen aufgenommen und intrazellulär in der perinuklearen Region lokalisiert werden (unten im Bild).

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“…117 Also very high molecular weight hyperbranched PG (up to 700 kDa) appears to have little effect on the biocompatibility in vitro for blood compatibility, viscosity, complement activation, platelet activation, plasma protein precipitation, and cytotoxicity. 118 Although the biocompatibility of polymers in general is a function of molecular weight, the inherently compact hyperbranched structure appears to remove many of the disadvantages associated with the exposure of high molecular weight linear polymers to blood and cells: in solution, hbPG s behave more like proteins than linear polymers. The plasma circulation half-life of hbPG in mice was found to be between 32 h for a molecular weight of 106 kDa and 58 h for polymers with 540 kDa.…”

Section: Biocompatibilitymentioning

confidence: 99%

Hyperbranched aliphatic polyether polyols

Schömer

Schüll

Frey

2012

J. Polym. Sci. A Polym. Chem.

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Hyperbranched polymers, dendritic macromolecules with branch-on-branch structures, have become an important polymer class since the early 1990s. They combine several advantages of the perfectly branched dendrimers with easy accessibility, typically in a one-step synthesis. Hyperbranched polyethers are a particularly interesting class of chemically stable and often biocompatible materials. Multifunctional hyperbranched polyethers with controllable molar mass and comparably low polydispersities can been prepared using hydroxyl-functional epoxides or oxetanes for polymerization via anionic and cationic polymerization mechanisms. Here, we review the progress in the preparation, characterization, and application of these uniquely versatile aliphatic polyether polyols. Their unusual mechanical, thermal, and solution properties render them useful for a variety of applications, for example, as building blocks for various complex macromolecular architectures or in biomedical applications.

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In vitro biological evaluation of high molecular weight hyperbranched polyglycerols

Cited by 238 publications

References 56 publications

Dendritic Polyglycerols for Biomedical Applications

Dendritic Polyglycerols for Biomedical Applications

Biokompatible funktionalisierte zellgängige Polyglycerinmikrogele

Hyperbranched aliphatic polyether polyols

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