In vitro characteristics of a mid-infrared continuous glucose sensor

Herrmann, Carina; Vrančić, Christian; Fomichova, Anna; Gretz, Norbert; Hoecker, Sabine; Pucci, Annemarie; Petrich, Wolfgang

doi:10.1117/12.841847

Cited by 4 publications

(1 citation statement)

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“…The optimum balance between gain in absorbance signal and increase in noise with increasing sample thickness appears to be around 20 mm for our setup, which agrees well with our prior estimates. 28 The single-pixel as well as the pixel-to-pixel noise also peak around that thickness.…”

Section: Faraday Discussion Papermentioning

confidence: 98%

Advancements in quantum cascade laser-based infrared microscopy of aqueous media

et al. 2016

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The large mid-infrared absorption coefficient of water frequently hampers the rapid, label-free infrared microscopy of biological objects in their natural aqueous environment. However, the high spectral power density of quantum cascade lasers is shifting this limitation such that mid-infrared absorbance images can be acquired in situ within signal-to-noise ratios of up to 100. Even at sample thicknesses well above 50 μm, signal-to-noise ratios above 10 are readily achieved. The quantum cascade laser-based microspectroscopy of aqueous media is exemplified by imaging an aqueous yeast solution and quantifying glucose consumption, ethanol generation as well as the production of carbon dioxide gas during fermentation.

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Section: Faraday Discussion Papermentioning

confidence: 98%

Advancements in quantum cascade laser-based infrared microscopy of aqueous media

et al. 2016

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Quantum cascade lasers (QCLs) in biomedical spectroscopy

2017

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Quantum cascade lasers (QCL) are the first room temperature semiconductor laser source for the mid-IR spectral region, triggering substantial development for the advancement of mid-IR spectroscopy. Mid-IR spectroscopy in general provides rapid, label-free and objective analysis, particularly important in the field of biomedical analysis. Due to their unique properties, QCLs offer new possibilities for development of analytical methods to enable quantification of clinically relevant concentration levels and to support medical diagnostics. Compared to FTIR spectroscopy, novel and elaborated measurement techniques can be implemented that allow miniaturized and portable instrumentation. This review illustrates the characteristics of QCLs with a particular focus on their benefits for biomedical analysis. Recent applications of QCL-based spectroscopy for analysis of a variety of clinically relevant samples including breath, urine, blood, interstitial fluid, and biopsy samples are summarized. Further potential for technical advancements is discussed in combination with future prospects for employment of QCL-based devices in routine and point-of-care diagnostics.

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Monitoring of heparin concentration in serum by Raman spectroscopy within hollow core photonic crystal fiber

et al. 2011

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The feasibility of using hollow core photonic crystal fiber (HC-PCF) in conjunction with Raman spectroscopy has been explored for real time monitoring of heparin concentration in serum. Heparin is an important blood anti-coagulant whose precise monitoring and controlling in patients undergoing cardiac surgery and dialysis is of utmost importance. Our method of heparin monitoring offers a novel alternative to existing clinical procedures in terms of accuracy, response time and sample volume. The optical design configuration simply involves a 785-nm laser diode whose light is coupled into HC-PCF filled with heparin-serum mixtures. By non-selectively filling HC-PCF, a strong modal field overlap is obtained. Consequently, an enhanced Raman signal (>90 times) is obtained from various heparin-serum mixtures filled HC-PCFs compared to its bulk counterpart (cuvette). The present scheme has the potential to serve as a 'generic biosensing tool' for diagnosing a wide range of biological samples.

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In vitro characteristics of a mid-infrared continuous glucose sensor

Cited by 4 publications

References 0 publications

Advancements in quantum cascade laser-based infrared microscopy of aqueous media

Advancements in quantum cascade laser-based infrared microscopy of aqueous media

Quantum cascade lasers (QCLs) in biomedical spectroscopy

Monitoring of heparin concentration in serum by Raman spectroscopy within hollow core photonic crystal fiber

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