In vitro characterization and in vivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles

lekshmi, U.M. Dhana; Poovi, G.; Kishore, Narra; Reddy, P. Neelakanta

doi:10.1016/j.ijpharm.2010.06.023

Cited by 91 publications

(48 citation statements)

References 34 publications

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“…Two mass losses occurred in the corroborating with XRD analysis. The comparisonbetweenthe FT-IR spectra of MNPsZnPc-PMMA NPs and free ZnPc confirmed that there is no significant interaction between ZnPc and the polymer showing that ZnPcwas located in the polymeric matrix (molecularly dispersed)and not at the surface [44,48].These results also corroborate the XRD analysis.…”

Section: Fig2supporting

confidence: 80%

“…The XRD profile of free ZnPc shows a crystalline form related to β-phase of monoclinic structure.However, these peaks were not observed in the XRD patterns of MNPsZnPc-PMMA NPs. Therefore, the diffractograms of the MNPsZnPc-PMMA NPs indicate that the drug would be either molecularly dispersed in the polymers or distributed in an amorphous state or in very small crystals [48].…”

Section: Figmentioning

confidence: 99%

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Simultaneous encapsulation of magnetic nanoparticles and zinc phthalocyanine in poly(methyl methacrylate) nanoparticles by miniemulsion polymerization and in vitro studies

Feuser

Fernandes

Nele

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Section: Fig2supporting

confidence: 80%

Section: Figmentioning

confidence: 99%

Simultaneous encapsulation of magnetic nanoparticles and zinc phthalocyanine in poly(methyl methacrylate) nanoparticles by miniemulsion polymerization and in vitro studies

Feuser

Fernandes

Nele

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…Toxicological studies with the use of PMMA nanoparticles with satisfactory results were obtained by Lekshmi et al [28] when evaluating in vivo toxicity in albino rats. Authors did not detect any changes in anatomopathological, haematological, and biochemical parameters.…”

Section: International Journal Of Polymer Sciencementioning

confidence: 84%

Method Validation for Progesterone Determination in Poly(methyl methacrylate) Nanoparticles Synthesized via Miniemulsion Polymerization

Fogolari

Felippe

Leimann

et al. 2017

International Journal of Polymer Science

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Exogenous progesterone has several applications in human health and in veterinary medicine, especially in fixed-time artificial insemination protocol. Progesterone nanoencapsulation in biocompatible polymers, such as poly(methyl methacrylate) (PMMA), is an alternative to substitute silicone-based release device traditionally used for estrus control. Progesterone concentration inside the nanoparticles must be precisely known; for that reason, a validation methodology must be applied to ensure reliable results, suitable for nanoparticles application. In this work, an UV-Vis spectrophotometric method was validated for the determination of progesterone in PMMA nanoparticles synthesized by miniemulsion polymerization. Chloroform was used as solvent, showing selectivity to the encapsulated drug and the components of the polymeric matrix did not influence progesterone recovery. Detection and quantitation limits (DL and QL) obtained were 0.32 and 0.96 mg⋅L −1 , respectively, and precision tests (between different analysts and equipment) indicated acceptable Relative Standard Deviations (RSD < 5%). Miniemulsion polymerization reactions were carried out producing two different morphologies: nanospheres (NS) and nanocapsules (NC), with average intensity diameters (Dz) of 150-200 nm and 240-300 nm, respectively. Polymerization gravimetric conversions obtained for both cases were higher than 95% and encapsulation efficiencies greater than 69% and 90% for the nanospheres and nanocapsules, respectively.

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“…Reduced dosing frequency (Cetin et al, 2013) Glibenclamide Improved dissolution rate (Yu et al, 2011) Repaglinide Offered prolonged release and avoided associated side effect (Lekshmi et al, 2010) …”

Section: Metforminmentioning

confidence: 99%

“…In vivo study is to be done NPs illustrated prolong drug release and the toxicological studies revealed NPs formulations safe to administer Lekshmi et al (2010) 6. Exenatide Sustained delivery La-phosphatidylch oline and Pluronic F-68…”

Section: Solvent Evaporationmentioning

confidence: 99%

Novel drug delivery system: an immense hope for diabetics

et al. 2014

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Context: Existing medication systems for the treatment of diabetes mellitus (DM) are inconvenient and troublesome for effective and safe delivery of drugs to the specific site. Therefore, investigations are desired to deliver antidiabetics using novel delivery approaches followed by their commercialization. Objective: The present review aims to provide a compilation on the latest development in the field of novel drug delivery systems (NDDSs) for antidiabetics with special emphasis on particulate, vesicular and miscellaneous systems. Methods: Review of literature (restricted to English language only) was done using electronic databases like Pubmed Õ and Scirus, i.e. published during [2005][2006][2007][2008][2009][2010][2011][2012][2013]. The CIMS/MIMS India Medical Drug Information eBook was used regarding available marketed formulation of antidiabetic drugs. Keywords used were ''nanoparticle'', ''microparticle'', ''liposomes'', ''niosomes'', ''transdermal systems'', ''insulin'', ''antidiabetic drugs'' and ''novel drug delivery systems''. Single inclusion was made for one article. If in vivo study was not done then article was seldom included in the manuscript. Results: The curiosity to develop NDDSs of antidiabetic drugs with special attention to the nanoparticulate system followed by microparticulate and lipid-based system is found to emerge gradually to overcome the problems associated with the conventional dosage forms and to win the confidence of end users towards the higher acceptability. Conclusion: In the current scientific panorama when the area of novel drug delivery system has been recognized for its palpable benefits, unique potential of providing physical stability, sustained and site-specific drug delivery for a scheduled period of time can open new vistas for precise, safe and quality treatment of DM.

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In vitro characterization and in vivo toxicity study of repaglinide loaded poly (methyl methacrylate) nanoparticles

Cited by 91 publications

References 34 publications

Simultaneous encapsulation of magnetic nanoparticles and zinc phthalocyanine in poly(methyl methacrylate) nanoparticles by miniemulsion polymerization and in vitro studies

Simultaneous encapsulation of magnetic nanoparticles and zinc phthalocyanine in poly(methyl methacrylate) nanoparticles by miniemulsion polymerization and in vitro studies

Method Validation for Progesterone Determination in Poly(methyl methacrylate) Nanoparticles Synthesized via Miniemulsion Polymerization

Novel drug delivery system: an immense hope for diabetics

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