In vitro characterization of the effectiveness of enhanced sewage treatment processes to eliminate endocrine activity of hospital effluents

Maletz, Sibylle; Floehr, Tilman; Beier, Silvio; Klümper, Claudia; Brouwer, Abraham; Behnisch, Peter; Higley, Eric; Giesy, John P.; Hecker, Markus; Gebhardt, Wilhelm; Linnemann, Volker; Pinnekamp, Johannes; Hollert, Henner

doi:10.1016/j.watres.2012.12.008

Cited by 90 publications

(57 citation statements)

References 67 publications

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“…The two main sources of pharmaceuticals entering the environment are sewage from urbanised areas, ending up in sewage treatment works (STWs), and livestock feedlots using pharmaceuticals for growth promotion and disease control (Maletz et al, 2013). Through these pathways of exposure, several types of PPCPs (such as anti-inflammatory drugs, antibiotics, anti-epileptics, anti-depressants, skin care products, disinfectants, etc.)…”

Section: Sources and Emission Routes Of Pharmaceuticals Into The Envimentioning

confidence: 99%

“…eventually end up at water treatment facilities with the hope that these chemicals are effectively removed before being discharged into rivers and impoundments downstream. Although the amount of PPCP waste products from producers is relatively low (GWRC, 2003), several other industries, such as hospitals and clinics, can contribute greatly to the discharge of PPCPs through sewage and wastewater into the environment (Maletz et al, 2013;Al Aukidy et al, 2014). One way of estimating the levels of PPCPs in the environment is to gather information regarding the usage of PPCPs by the general public in the area of concern.…”

Section: Sources and Emission Routes Of Pharmaceuticals Into The Envimentioning

confidence: 99%

See 1 more Smart Citation

Review: <i>Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters</i>

Archer

Wolfaardt

Wyk

2017

WSA

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Globally, water resources are under constant threat of being polluted by a diverse range of man-made chemicals, and South Africa is no exception. These contaminants can have detrimental effects on both human and wildlife health. It is increasingly evident that several chemicals may modulate endocrine system pathways in vertebrate species, and these are collectively referred to as endocrine disrupting contaminants (EDCs). Although the endocrine-disrupting effect of water pollutants has been mainly linked to agricultural pesticides and industrial effluents, other pollutants such as pharmaceuticals and personal care products (PPCPs) are largely unnoticed, but also pose a potentially significant threat. Here we present for the first time in a South African context, a summarised list of PPCPs and other EDCs detected to date within South African water systems, as well as their possible endocrine-disrupting effect in-vitro and in-vivo. This review addresses other factors which should be investigated in future studies, including endocrine disruption, PPCP metabolites, environmental toxicology, and antibiotic resistance. The challenges of removing EDCs and other pollutants at South African wastewater treatment works (WWTWs) are also highlighted. The need for focused research involving both in-vitro and in-vivo studies to detect PPCPs in water systems, and to delineate adverse outcome pathways (AOPs) of priority PPCPs to aid in environmental impact assessment (EIA), are discussed.

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Section: Sources and Emission Routes Of Pharmaceuticals Into The Envimentioning

confidence: 99%

Section: Sources and Emission Routes Of Pharmaceuticals Into The Envimentioning

confidence: 99%

Review: <i>Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters</i>

Archer

Wolfaardt

Wyk

2017

WSA

View full text Add to dashboard Cite

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“…This was substantiated by Maletz et al (2013) in the survey of articles and abstract available online from more than 15,475 international journals and other science scholar database. It is on this basis that other AOTs such as electrohydraulic discharge process, heterogeneous photocatalysis, and ultrasonic irradiation were considered and reviewed accordingly.…”

mentioning

confidence: 84%

“…produces toxic disinfection by-products 3 (DBP) that are genotoxic, mutagenic, and carcinogenic to human health. Adsorption produces toxic sludge, and, not just that, pollutants are being transformed from one phase to another without necessarily being decomposed (Kasprzyk-Hordern et al 2009;Maletz et al 2013). Other treatment processes may be hindered by economics and wastewater characteristics.…”

Section: Introductionmentioning

confidence: 99%

A Review of Combined Advanced Oxidation Technologies for the Removal of Organic Pollutants from Water

Tijani

Fatoba

Madzivire

et al. 2014

Water Air Soil Pollut

212

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Water pollution through natural and anthropogenic activities has become a global problem causing short-and long-term impact on human and ecosystems. Substantial quantity of individual or mixtures of organic pollutants enter the surface water via point and nonpoint sources and thus affect the quality of freshwater. These pollutants are known to be toxic and difficult to remove by mere biological treatment. To date, most researches on the removal of organic pollutants from wastewater were based on the exploitation of individual treatment process. This single-treatment technology has inherent challenges and shortcomings with respect to efficiency and economics. Thus, application of two advanced treatment technologies characterized with high efficiency with respect to removal of primary and disinfection byproducts in wastewater is desirable. This review article focuses on the application of integrated technologies such as electrohydraulic discharge with heterogeneous photocatalysts or sonophotocatalysis to remove target pollutants. The information gathered from more than 100 published articles, mostly laboratories studies, shows that process integration effectively remove and degrade recalcitrant toxic contaminants in wastewater better than singletechnology processing. This review recommends an improvement on this technology (integrated electrohydraulic discharge with heterogeneous photocatalysts) viz-a-vis cost reduction in order to make it accessible and available in the rural and semi-urban settlement. Further recommendation includes development of an economic model to establish the cost implications of the combined technology. Proper monitoring, enforcement of the existing environmental regulations, and upgrading of current wastewater treatment plants with additional treatment steps such as photocatalysis and ozonation will greatly assist in the removal of environmental toxicants.

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“…The concentration of potential chemicals may be related to hospital scale, that is, large hospitals equate to high concentrations of potential chemicals [25]. Although traditional wastewater treatment technologies could remove these potential chemicals to some extent, the remaining compounds are harmful to aquatic organisms and even to humans who experience a prolonged exposure at low concentrations [26]. The toxicological effects and damages of potential chemicals are listed in Table 1.…”

Section: Toxicological Effects and Damages Of Potential Chemicalsmentioning

confidence: 99%

Research Advancements in Ozone Treatment for Estrogenic Activities in Hospital Wastewater

Zhao¹,

Weilian²,

Chen³

et al. 2017

JRST

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hospital wastewater (hWW) is a source of estrogenic activity compounds in the environmental water system. once released into water bodies, these compounds disrupt the aquatic ecological balance and even affect human health. on the basis of domestic and foreign literature, the potential chemicals and their properties, such as construction features and toxicological effects, in hWW were summarized and discussed. The advantages of ozone in removing target substances were also summarized.

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In vitro characterization of the effectiveness of enhanced sewage treatment processes to eliminate endocrine activity of hospital effluents

Cited by 90 publications

References 67 publications

Review: <i>Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters</i>

Review: <i>Pharmaceutical and personal care products (PPCPs) as endocrine disrupting contaminants (EDCs) in South African surface waters</i>

A Review of Combined Advanced Oxidation Technologies for the Removal of Organic Pollutants from Water

Research Advancements in Ozone Treatment for Estrogenic Activities in Hospital Wastewater

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