2009
DOI: 10.1590/s0102-695x2009000300001
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In vitro cytotoxic, antioxidant and antiviral effects of Pterocaulon alopecuroides and Bidens segetum extracts

Abstract: RESUMO: "Efeitos citotóxico, antioxidante e antiviral in vitro de extratos de Pterocaulon alopecuroides e Bidens segetum". Pterocaulon alopecuroides (Lamark) De Candolle e Bidens segetum Mart. ex Colla são duas espécies pertencentes à família Asteraceae. Os extratos dessas duas espécies foram avaliados quanto às suas atividades citotóxica, antioxidante e antiviral. Todos os extratos analisados apresentaram citotoxidade muito alta contra linhagens de células RBL-2H3. O ensaio de atividade antioxidante demonstro… Show more

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Cited by 7 publications
(4 citation statements)
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“…At the same time the selected compounds should not be able to cross the BBB to avoid any possible side effects or complications in the brain. Among the rst series, 28 compounds were selected, which included antiviral (AV) compounds with the following numbers: 4, 5, 7, 9, 10,11,16,18,20,21,25,29,30,32,33,34,35,36,37,38, 41, 52, 53, 64, 65, 66, 67, and 78 (Fig. 4).…”
Section: Docking Analysismentioning
confidence: 99%
See 1 more Smart Citation
“…At the same time the selected compounds should not be able to cross the BBB to avoid any possible side effects or complications in the brain. Among the rst series, 28 compounds were selected, which included antiviral (AV) compounds with the following numbers: 4, 5, 7, 9, 10,11,16,18,20,21,25,29,30,32,33,34,35,36,37,38, 41, 52, 53, 64, 65, 66, 67, and 78 (Fig. 4).…”
Section: Docking Analysismentioning
confidence: 99%
“…12,13 Furthermore, antiviral activities of coumarins have been reported. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] They include antihepatitis B virus as for nordentatin and clausarin, 17 antihepatitis C virus as in the case of wedelolactone, glycycoumarin, and glycyrin, 14,15 anti-HIV as for calanolides A, B, and C and for inophyllums A, B, C, E, and P, anti-human inuenza virus as for eleutheroside B1, 15,17 anti-dengue virus as for ramosin, myrsellinol, and myresellin, 17 anti-herpes simplex HSV as in the case of rutamarin, 14 anti-poliovirus as for isoobtusitin, 31 and anti-chikungunya virus as for coumarins A and B from Mammea americana. 15 Recently, in a preliminary screening 29 naturally occurring coumarins as potential SARS-CoV-2 replication inhibitors by docking technique have been investigated, out of which 17 compounds were found to bind to the active site through the interaction with the catalytic dyad, His41 and Cys145, along with other neighboring residues.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, Bidens segetum Martius ex Colla (Helianthe, Asteraceae) is a native species from the Brazilian Cerrado that until now has not been thoroughly investigated. Recent studies have described its reproductive biology, addressing the dynamics of flowering and pollination, fruit set and seed dispersal, and there is also a report about the cytotoxic and antioxidant activities of the extracts obtained from its aerial parts and flowers (7,8).…”
Section: Please Scroll Down For Articlementioning
confidence: 99%
“…On the other hand, polyacetylenes isolated from Bidens pilosa could modulate the differentiation of human helper T cells and prevent autoimmune diabetes in mice and demonstrating antiproliferative effect on normal and rapidly growing human transformed cell lines [12] [13]. Bidens segetum is still little studied, but tests with ethanolic extract of flowers, stems and leaves showed cytotoxic effect against cancer cells and antioxidant activity from the ethyl acetate fraction [14].…”
Section: Introductionmentioning
confidence: 99%