In Vitro Degradability, Microstructural Evaluation, and Biocompatibility of Zn-Ti-Cu-Ca-P Alloy

Navaneethakrishnan, G.; Palaniyandi, Parameswaran; Palanisamy, R.; Panchal, Hitesh; Ibrahim, Ahmed Mohamed Mahmoud; Alsoufi, Mohammad S.; Elsheikh, Ammar H.

doi:10.3390/nano12081357

Cited by 13 publications

(10 citation statements)

References 39 publications

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“…In addition, Zn-based implants are also a promising biodegradable material with great biocompatibility and functionality. − Zn-based implants can release zinc ions for affecting cell adhesion and promoting new bone formation . Unfortunately, the yield strength and elongation of pure Zn alloy is extremely low, and thereby Zn-based alloys were integrated with other elements for better mechanical performance .…”

Section: Bone Regenerative Fixationmentioning

confidence: 99%

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

et al. 2023

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Bone fractures have always been a burden to patients due to their common occurrence and severe complications. Traditionally, operative treatments have been widely used in the clinic for implanting, despite the fact that they can only achieve bone fixation with limited stability and pose no effect on promoting tissue growth. In addition, the nondegradable implants usually need a secondary surgery for implant removal, otherwise they may block the regeneration of bones resulting in bone nonunion. To overcome the low degradability of implants and avoid multiple surgeries, tissue engineers have investigated various biodegradable materials for bone regeneration, whereas the significance of stability of long-term bone fixation tends to be neglected during this process. Combining the traditional orthopedic implantation surgeries and emerging tissue engineering, we believe that both bone fixation and bone regeneration are indispensable factors for a successful bone repair. Herein, we define such a novel idea as bone regenerative fixation (BRF), which should be the main future development trend of biodegradable materials.

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Section: Bone Regenerative Fixationmentioning

confidence: 99%

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

et al. 2023

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“…[38,61,64], with Zn-Mg and Zn-Cu being the predominant types. A small portion of Zn alloys comprised additional Al [47], Fe [49,50,84,85], Ca [58,77,88], Ge [55], Ti [54,87], Sr [65,72,76], Si [84], Zr [31,33], Sn [47], and V [59]. In addition, pure Zn was alloyed with rare-earth elements (REEs) such as Er, Dy, Ho, Ce, and Gd [57,68,78].…”

Section: Quality Assessment According To the Toxrtoolmentioning

confidence: 99%

“…The morphological geometry of the test samples was varied, including discs, porous scaffolds [37,39,53], various thread types [60,70], foil [60], wires [40], membranes [85,87], and cylinders [25]. In terms of the preparation and processing of test samples, casting, hot-rolling, and hot-extruding were the main manufacturing processes for biodegradable Zn and its alloys.…”

Section: Quality Assessment According To the Toxrtoolmentioning

confidence: 99%

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Cytotoxicity of Biodegradable Zinc and Its Alloys: A Systematic Review

Liu

et al. 2023

JFB

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Zinc-based biodegradable metals (BMs) have been developed for biomedical implant materials. However, the cytotoxicity of Zn and its alloys has caused controversy. This work aims to investigate whether Zn and its alloys possess cytotoxic effects and the corresponding influence factors. According to the guidelines of the PRISMA statement, an electronic combined hand search was conducted to retrieve articles published in PubMed, Web of Science, and Scopus (2013.1–2023.2) following the PICOS strategy. Eighty-six eligible articles were included. The quality of the included toxicity studies was assessed utilizing the ToxRTool. Among the included articles, extract tests were performed in 83 studies, and direct contact tests were conducted in 18 studies. According to the results of this review, the cytotoxicity of Zn-based BMs is mainly determined by three factors, namely, Zn-based materials, tested cells, and test system. Notably, Zn and its alloys did not exhibit cytotoxic effects under certain test conditions, but significant heterogeneity existed in the implementation of the cytotoxicity evaluation. Furthermore, there is currently a relatively lower quality of current cytotoxicity evaluation in Zn-based BMs owing to the adoption of nonuniform standards. Establishing a standardized in vitro toxicity assessment system for Zn-based BMs is required for future investigations.

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“…The stress concentration between the carbides and matrix, which was always ignored, gave the pivotal importance on the surface damage under service condition. [14][15][16] The results of Ding et al [17] showed that dislocation entanglements were formed around the coarse carbides, leading to a high concentration of stress and accelerated fatigue crack extension. Gammage et al [18] observed that inhomogeneity in precipitate distributions leads to local stress concentration, which is a key factor in interfacial heterogeneous fracture initiation.…”

Section: Introductionmentioning

confidence: 99%

A Novel Classification Method for Carbide Grade by Using a New Shape Factor with Stress Distribution Analysis

Yao,

Cheng,

Fang

et al. 2024

steel research int.

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The carbide gradation related to geometry size and local stress concentration sensitivity significantly impacts the performance of the carburized 16Cr3NiWMoVNbE steel. The conventional metallurgical graphic comparison method by manual comparison is not capable of grading the carbide gradation automatically. A novel method is thus introduced to automatically evaluate the carbide grade by using a new shape factor φsc with stress distribution analysis instead of using the circularity or roundness shape factor which only considers the geometry shape of carbide particles. The logarithm of the stress concentration factor ln(K) is linearly related to the logarithm of the shape factor ln(φsc). The gradient b of the fitted straight line shows sensitivity to the carbide grade. The gradients are b1 = 0.039, b3 = 0.049, and b5 = 0.055 for the three carbide classes from low to high. Furthermore, there is also a linear relationship between hardness in different grades of carbide microstructure and the gradient b.

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In Vitro Degradability, Microstructural Evaluation, and Biocompatibility of Zn-Ti-Cu-Ca-P Alloy

Cited by 13 publications

References 39 publications

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

Cytotoxicity of Biodegradable Zinc and Its Alloys: A Systematic Review

A Novel Classification Method for Carbide Grade by Using a New Shape Factor with Stress Distribution Analysis

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