In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin

Yan, Wei; Lian, Yi-Jie; Zhang, Zhiyuan; Zeng, Mei-Qi; Zhang, Zhaoqi; Yin, Zheng-Zheng; Cui, Lan-Yue; Zeng, Rong‐Chang

doi:10.1016/j.bioactmat.2020.02.015

Cited by 62 publications

(53 citation statements)

References 69 publications

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“…Currently, Mg and its alloys have been widely used in bone implant materials, and the degradable Mg bone nail developed by Yian Technology Co., Ltd. has been officially certified by Conformite Europeenne (CE). Moreover, Mg alloys are a promising material for cardiovascular stents because of their high elastic modulus, fine mechanical characteristics, and biodegradability [ 10 , [31] , [32] , [33] , [34] ]. Mg-based stents have potential advantages over polymeric stents in terms of higher radial strength due to their metallic nature and biocompatibility as a naturally occurring element in the body.…”

Section: Introductionmentioning

confidence: 99%

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

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109

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Magnesium (Mg) and its alloys, as potential biodegradable materials, have drawn wide attention in the cardiovascular stent field because of their appropriate mechanical properties and biocompatibility. Nevertheless, the occurrence of thrombosis, inflammation, and restenosis of implanted Mg alloy stents caused by their poor corrosion resistance and insufficient endothelialization restrains their anticipated clinical applications. Numerous surface treatment tactics have mainly striven to modify the Mg alloy for inhibiting its degradation rate and enduing it with biological functionality. This review focuses on highlighting and summarizing the latest research progress in functionalized coatings on Mg alloys for cardiovascular stents over the last decade, regarding preparation strategies for metal oxide, metal hydroxide, inorganic nonmetallic, polymer, and their composite coatings; and the performance of these strategies in regulating degradation behavior and biofunction. Potential research direction is also concisely discussed to help guide biological functionalized strategies and inspire further innovations. It is hoped that this review can give assistance to the surface modification of cardiovascular Mg-based stents and promote future advancements in this emerging research field.

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Section: Introductionmentioning

confidence: 99%

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Zhang

Yang

et al. 2021

Bioactive Materials

Self Cite

109

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“…The classification of the activity at 556 cm −1 is more difficult. Based on the current literature, it indicates the presence of hydroxide groups (OH − ) [35] or also of phosphate compounds [22,34]. Similarly, the broad activity between 3630 and 2460 cm −1 , occurring only for the accelerated immersion tests, indicates the presence of OH − [34,35].…”

Section: Discussionmentioning

confidence: 98%

Assessment of Galvanostatic Anodic Polarization to Accelerate the Corrosion of the Bioresorbable Magnesium Alloy WE43

Wegner

Walther

2021

Applied Sciences

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In the field of surgery, bioresorbable magnesium is considered a promising candidate. Its low corrosion resistance, which is disadvantageous for technical application, is advantageous for surgery since the implant fully degrades in the presence of the water-based body fluids, and after a defined time the regenerating bone takes over its function again. Therefore, knowledge of the corrosion behavior over several months is essential. For this reason, an in vitro short-time testing method is developed to accelerate the corrosion progress by galvanostatic anodic polarization without influencing the macroscopic corrosion morphology. The initial corrosion rate of the magnesium alloy WE43 is calculated by detection of the hydrogen volume produced in an immersion test. In a corresponding experimental setup, a galvanostatic anodic polarization is applied with a three-electrode system. The application range for the polarization is determined based on the corrosion current density from potentiodynamic polarization. To correlate the initial corrosion rate, and accelerated dissolution rate, the corrosion morphologies of both test strategies are characterized by microscopy images, as well as energy dispersive X-ray spectroscopy and Fourier-transform infrared spectroscopy. The results demonstrate that the dissolution rate can be increased in the order of decades with the limitation of a changed corrosion morphology with increasing polarization. With this approach, it is possible to characterize and exclude new unsuitable magnesium alloys in a time-efficient manner before they are used in subsequent preclinical studies.

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“…However, Mg(OH) 2 is swiftly converted into soluble MgCl 2 due to the Cl − attack at the OH − site in the body fluid [ 54 ]. The interaction of the free Mg ions with CO 3 2− and HCO 3− favors the passivation of the surface of the Mg-based implants via formation of the insoluble MgCO 3 precipitates [ 55 ].…”

Section: Challenges Encountered By Mg-based Interference Screws For Cmentioning

confidence: 99%

Clinical translation and challenges of biodegradable magnesium-based interference screws in ACL reconstruction

Luo

Zhang

Wang³

et al. 2021

Bioactive Materials

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As one of the most promising fixators developed for anterior cruciate ligament (ACL) reconstruction, biodegradable magnesium (Mg)-based interference screws have gained increasing attention attributed to their appropriate modulus and favorable biological properties during degradation after surgical insertion. However, its fast degradation and insufficient mechanical strength have also been recognized as one of the major causes to limit their further application clinically. This review focused on the following four parts. Firstly, the advantages of Mg or its alloys over their counterparts as orthopaedic implants in the fixation of tendon grafts in ACL reconstruction were discussed. Subsequently, the underlying mechanisms behind the contributions of Mg ions to the tendon-bone healing were introduced. Thirdly, the technical challenges of Mg-based interference screws towards clinical trials were discussed, which was followed by the introduction of currently used modification methods for gaining improved corrosion resistance and mechanical properties. Finally, novel strategies including development of Mg/Titanium (Ti) hybrid fixators and Mg-based screws with innovative structure for achieving clinically customized therapies were proposed. Collectively, the advancements in the basic and translational research on the Mg-based interference screws may lay the foundation for exploring a new era in the treatment of the tendon-bone insertion (TBI) and related disorders.

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In vitro degradation of pure magnesium―the synergetic influences of glucose and albumin

Cited by 62 publications

References 69 publications

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Advances in coatings on magnesium alloys for cardiovascular stents – A review

Assessment of Galvanostatic Anodic Polarization to Accelerate the Corrosion of the Bioresorbable Magnesium Alloy WE43

Clinical translation and challenges of biodegradable magnesium-based interference screws in ACL reconstruction

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