In vitro degradation, photo-dynamic and thermal antibacterial activities of Cu-bearing chlorophyllin-induced Ca–P coating on magnesium alloy AZ31

Roles and current applications of S-nitrosoglutathione in anti-infective biomaterials

“…Therefore, Cu nanoparticles (Cu-NPs) provide an excellent option for the ion catalysis of GSNO. It is worth noting that Cu-NPs not only benefits GSNO decomposition and resultant NO production, but also interacts with other endogenous RSNOs in the blood [ 117 ] and exhibits intrinsic antimicrobial activity [ 118 , 119 ]. When using Cu-NPs to modify NO release from GSNO coated on polyvinyl chloride (PVC) (tubing for extracorporeal circulation) ( Fig.…”

Effects of Zinc, Magnesium, and Iron Ions on Bone Tissue Engineering

“…Out of these three things (scaffold, cells, and growth factors), the focus of this review is on the scaffold. A bone scaffold that mimics the properties of natural bone is crucial which includes sufficient porosity, biocompatibility, osteoinductive activity, and antibacterial property as well as optimal mechanical properties and degradability. ,,, Alloys and biodegradable metals have been widely used as scaffolds for bone repair, as their properties harbor great mechanical stiffness, meeting the high demands of mechanical support in human. − However, the degradation rates of these biomaterials are fast and cannot match with the natural bone healing rate, resulting in limitations for biomedical applications which need structural optimization of scaffolds to delay their degradation rates. − Metallic ions could regulate cell behavior, ,, and it has been reported that these ions can play important roles in the bone regeneration itself. − Therefore, integrating bone scaffolds with metal ions is a promising trend in bone tissue engineering. Zinc, magnesium, and iron ions are available metal ions, belonging to the element of natural bone.…”

In Vitro Degradation and Photoactivated Antibacterial Activity of a Hemin-CaP Microsphere-Loaded Coating on Pure Magnesium

“…Photoactivated sterilization has received more attention in recent years due to its advantages of rapid and effective bacteriostasis and broad-spectrum antibacterial activity [ 28 ]. To date, a variety of photo-responsive materials, such as inorganic nanoparticles [ 29 , 30 ], layered double hydroxides [ 31 , 32 ], cyanine-based agents [ 33 , 34 ], porphyrin-based agents [ 35 ] and diketone-based agents [ 36 ] have been attempted to fabricate antibacterial coatings on the surface of bone implants to deal with IAIs. Thereinto, porphyrins and porphyrin derivatives have considerable potential in biomedical applications because of their distinctive light-harvesting properties and photophysical properties [ 37 ].…”

“…Thereinto, porphyrins and porphyrin derivatives have considerable potential in biomedical applications because of their distinctive light-harvesting properties and photophysical properties [ 37 ]. For instance, their porphyrin macrocycles can transform near-infrared (NIR) light into heat for photothermal therapy (PTT) and produce reactive oxygen species (ROS) for photodynamic therapy (PDT) [ 35 , 38 ]. Our prior research [ 35 ] prepared a sodium copper chlorophyllin induced calcium-bearing phosphate coating on the Mg alloy AZ31 through layer-by-layer assembly.…”

“…For instance, their porphyrin macrocycles can transform near-infrared (NIR) light into heat for photothermal therapy (PTT) and produce reactive oxygen species (ROS) for photodynamic therapy (PDT) [ 35 , 38 ]. Our prior research [ 35 ] prepared a sodium copper chlorophyllin induced calcium-bearing phosphate coating on the Mg alloy AZ31 through layer-by-layer assembly. The antibacterial efficacy of the prepared coating against S. aureus and E. coli reached 99.8% and 99.9% in vitro through the combination of PTT, PDT and Cu 2+ ion release.…”