In Vitro Determination of Antimicrobial and Hypoglycemic Activities of Mikania cordata (Asteraceae) Leaf Extracts

Jayatilake, Pavithra L.; Munasinghe, Helani

doi:10.1155/2020/8674708

Cited by 3 publications

References 21 publications

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Exploring the Traditional System of Medicine With Special Emphasis on the Indigenous Practice of Herbal Remedy by the Tribals of North-East India

Kumar¹,

Kushari²,

Sarma

et al. 2023

Practice and Re-Emergence of Herbal Medicine

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The tribal people of India consider North-East India to be a hotspot. It contains eight states: Arunachal Pradesh, Assam, Manipur, Mizoram, Meghalaya, Nagaland, Tripura and Sikkim, and it borders international boundaries with Bhutan, Tibet, China, Burma and Bangladesh. The Indo-Burma biodiversity hotspot, which is home to a broad spectrum of unusual flora, fauna and microorganisms, is located in the Northeast Region. The region has the evergreen forest of the Brahmaputra River valley, wide leaf forest, dense bamboo and pine forest and the world's wettest location (Cherrapunji and Mawsynram), all of which help to maintain the region's unique biodiversity. North East region is the inhabitant of more than 145 significant tribal communities with the most dominating primitive societies, including the Abor, Mishing, Rabha, Khasi, Kuki, Naga, Meitei, Apatani, etc. Most of these communities are culturally and linguistically diverse. The NER's tribal population is literate compared to other parts of the country, and it's worth noting that the literacy rates in Mizoram, Meghalaya, Nagaland, Sikkim and Manipur are all higher than the national average. Despite their high literacy rate, India's North-Eastern states continue to have poor transportation, power and medical services. The healthcare system is in bad shape, with only a few hospitals and nursing homes. As a result, the people residing in this area rely exclusively on a traditional system of medicines made by traditional healers from plants, animals and mineral resources. It was stated that medicinal herbs are prepared using traditional methods, such as maceration, decoction, and infusion, either alone or in combination with other plants. The key species of medicinal plants often employed by the traditional healers of the region are Acorus calamus, Aegle marmelos, Asparagus racemosus, Averrhoa carambola, Bryophyllum calycinum, Costus speciosus, Euphorbia neriifolia, Justicia adhatoda, Melia azadarachta, Plumeria acutifolia, Sida cordifolia, Sida rhombifolia and Swertia chirata. This extensive work will aid the researcher in locating previously unknown medicinal plants in order to build a new therapeutic method for isolating new chemical entities that are safe, pharmacologically active, and cost-effective.

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Exploring the Traditional System of Medicine With Special Emphasis on the Indigenous Practice of Herbal Remedy by the Tribals of North-East India

Kumar¹,

Kushari²,

Sarma

et al. 2023

Practice and Re-Emergence of Herbal Medicine

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Ethnomedicinal Value of Antidiabetic Plants in Bangladesh: A Comprehensive Review

Rahman

Uddin

Reza

et al. 2021

Plants

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The use of conventional drugs to treat metabolic disorders and the pathological consequences of diabetes further increases the complications because of the side effects, and is sometimes burdensome due to relatively higher costs and occasionally painful route of administration of these drugs. Therefore, shifting to herbal medicine may be more effective, economical, have fewer side effects and might have minimal toxicity. The present review amasses a list of ethnomedicinal plants of 143 species belonging to 61 families, from distinctive domestic survey literature, reported to have been used to treat diabetes by the ethnic and local people of Bangladesh. Leaves of the medicinal plants were found leading in terms of their use, followed by fruits, whole plants, roots, seeds, bark, stems, flowers, and rhizomes. This review provides starting information leading to the search for and use of indigenous botanical resources to discover bioactive compounds for novel hypoglycemic drug development.

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Antidiabetic and Antioxidant Potential of Detarium microcarpum and Zanthoxylum zanthoxyloides and Combined Extract Efficacy in Rats

Amegah,

Larbie,

Sarfo-Antwi

et al. 2024

Asian J. Biol. Sci

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Background and Objective: Detarium microcarpum and Zanthoxylum zanthoxyloides are both tropical medicinal plants used for the treatment and management of numerous ailments including diabetes. This study sought to evaluate the antidiabetic potential and efficacy, antioxidant and safety profile of the plants and combined extracts of the Detarium microcarpum and Zanthoxylum zanthoxyloides. Materials and Methods: The combined (Detarium microcarpum and Zanthoxylum zanthoxyloides) and separate plant parts were extracted with different solvents. Phytochemical analysis, radical scavenging activity and heavy metal content assessments were conducted. The antidiabetic potential of the extracts was further evaluated in vivo by employing the Oral Glucose Tolerance Test (OGTT) in 21 Wistar rats. The safety profile of the extracts was evaluated by assessing the effect of the extracts on the percentage change in body weights, hematological parameters and biochemical parameters as well. One-way and two-way analysis of variance followed by Dunnett's multiple comparison test was used at p<0.05. Results: Alkaloids, terpenoids, saponins and tannins were present in aqueous extracts. The combined aqueous extract showed better radical scavenging activity. In a glucose tolerance test on rats, the combined extract demonstrated the most effective glucose reduction (from 6.83-4.60 mmol LG 1 ). Combined extract also had better antioxidant and antihyperglycemic effects compared to individual extracts. Conclusion: All extracts were safe concerning hematological and biochemical parameters.Combined extracts showed better therapeutic potential compared to the individual extracts.

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In Vitro Determination of Antimicrobial and Hypoglycemic Activities of Mikania cordata (Asteraceae) Leaf Extracts

Cited by 3 publications

References 21 publications

Exploring the Traditional System of Medicine With Special Emphasis on the Indigenous Practice of Herbal Remedy by the Tribals of North-East India

Exploring the Traditional System of Medicine With Special Emphasis on the Indigenous Practice of Herbal Remedy by the Tribals of North-East India

Ethnomedicinal Value of Antidiabetic Plants in Bangladesh: A Comprehensive Review

Antidiabetic and Antioxidant Potential of Detarium microcarpum and Zanthoxylum zanthoxyloides and Combined Extract Efficacy in Rats

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