In vitro determination of biomechanical properties of human articular cartilage in osteoarthritis using multi-parametric MRI

Identification of material parameters of cartilage for hip joint mechanical model

“…The parameters values obtained are also close to results found by Juras et al (2009), values of E 0 , H and h, respectively, ranged from 2.5 to 10.7 MPa (mean, 4 MPa), 0.4 to 3.9 MPa (mean, 1 MPa) and 11.0 to 330.0 MPa s (mean, 48.4 MPa s). For non-pathological femoral heads, mean values observed for E 0 , H and h parameters were 10.9 MPa, 2.2 MPa and 218.7 MPa s, respectively.…”

“…Many studies have been conducted on the mechanical properties of cartilage. It was shown that cartilage has a viscoelastic behaviour (Juras et al 2009;Villars et al in press). Moreover, some studies (Kurrat and Oberländer 1978) have reported a heterogeneity of femoral head cartilage thickness, cartilage being more or less thick depending on the considered area.…”

Preliminary Evaluation of Potential Disease Modification by Hylan G-F 20 (Synvisc®) Using dGEMRIC

“…The GAG distribution would then be inversely related to the Gd-DTPA 2-concentration, or directly related to the T 1 values after penetration of the contrast agent into the cartilage, T 1 (Gd) [9]. Studies in vitro have validated that proteoglycan estimates based on dGEMRIC measurements to be in very good agreement with biochemical assays or histology [10][11][12][13][14][15][16], and in vivo data that are consistent with the premise has been reported in animal models [17][18][19][20] and clinically [11,21].…”

Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis

“…We therefore cannot exclude the possibility that a layer-specific analysis with more than two echoes might have revealed significant results. However, a recent ex vivo study63 showed that dGEMRIC was significantly associated with cartilage mechanical properties (which are known to decline in ROA), but T2 was not.…”