In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication

Hajdrik, Polett; Pályi, Bernadett; Kis, Zoltán; Kovács, Noémi; Veres, Dániel Sándor; Szigeti, Krisztián; Budán, Ferenc; Hegedüs, Imre; Kovács, Tibor; Bergmann, Ralf; Máthé, Domokos

doi:10.3390/foods11050694

Cited by 12 publications

(16 citation statements)

References 70 publications

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“…Polyphenol structures are generally ROS-scavenging antioxidants that also exert antiinflammatory effects [51,52]. Thus, molecular features of flavonoids [53], chlorogenic acids, hydroxycinnamic acids, and the caffeine content of coffee [54] and melanoidins [17] exert antioxidant (ROS-quenching) effects, directly mitigating the ROS-induced cellular damage [55][56][57][58].…”

Section: Discussionmentioning

confidence: 99%

The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers

Molnar

Szabó

Tomesz

et al. 2022

Cells

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Polyphenols are capable of decreasing cancer risk. We examined the chemopreventive effects of a green tea (Camellia sinensis) extract, polyphenol extract (a mixture of blackberry (Rubus fruticosus), blackcurrants (Ribes nigrum), and added resveratrol phytoalexin), Chinese bayberry (Myrica rubra) extract, and a coffee (Coffea arabica) extract on 7,12-dimethylbenz[a]anthracene (DMBA) carcinogen-increased miR-134, miR-132, miR-124-1, miR-9-3, and mTOR gene expressions in the liver, spleen, and kidneys of CBA/Ca mice. The elevation was quenched significantly in the organs, except for miR-132 in the liver of the Chinese bayberry extract-consuming group, and miR-132 in the kidneys of the polyphenol-fed group. In the coffee extract-consuming group, only miR-9-3 and mTOR decreased significantly in the liver; also, miR-134 decreased significantly in the spleen, and, additionally, miR-124-1 decreased significantly in the kidney. Our results are supported by literature data, particularly the DMBA generated ROS-induced inflammatory and proliferative signal transducers, such as TNF, IL1, IL6, and NF-κB; as well as oncogenes, namely RAS and MYC. The examined chemopreventive agents, besides the obvious antioxidant and anti-inflammatory effects, mainly blocked the mentioned DMBA-activated factors and the mitogen-activated protein kinase (MAPK) as well, and, at the same time, induced PTEN as well as SIRT tumor suppressor genes.

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Section: Discussionmentioning

confidence: 99%

The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers

Molnar

Szabó

Tomesz

et al. 2022

Cells

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“…Zinc oxide and titanium dioxide coatings also show antiviral activity 134,135 . Antiviral heavy metals found in nutritional supplements may have some efficacy 136 . Quaternary ammonium compound coatings have attracted study 137,138 .…”

Section: Coating and Impregnation Barriersmentioning

confidence: 99%

Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

Cimolai

2022

Journal of Medical Virology

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Given the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) as witnessed early in the coronavirus disease 2019 (COVID‐19) pandemic, concerns arose with the existing methods for virus disinfection and decontamination. The need for SARS‐CoV‐2‐specific data stimulated considerable research in this regard. Overall, SARS‐CoV‐2 is practically and equally susceptible to approaches for disinfection and decontamination that have been previously found for other human or animal coronaviruses. The latter have included techniques utilizing temperature modulation, pH extremes, irradiation, and chemical treatments. These physicochemical methods are a necessary adjunct to other prevention strategies, given the environmental and patient surface ubiquity of the virus. Classic studies of disinfection have also allowed for extrapolation to the eradication of the virus on human mucosal surfaces by some chemical means. Despite considerable laboratory study, practical field assessments are generally lacking and need to be encouraged to confirm the correlation of interventions with viral eradication and infection prevention. Transparency in the constitution and use of any method or chemical is also essential to furthering practical applications.

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“…A linker material was used to stick the ZnO nanoparticles to the glass leather surface, Afterward, ZnO NPs was dispersed in an alcohol solution and then spread on the glass and leather surface to form a layer of zinc oxide nanoparticles. Zn2+ ions have a possible inhibitory effect on viral reproduction by increasing the content of intracellular Zn2+, which can effectively limit the replication of some RNA viruses [45][46][47]. This related with the fact that ZnONPs produce Zn2+ ions as well as different kinds of reactive oxygen species, and that these free radicals can destroy proteins, lipids, carbohydrates, and DNA, ultimately resulting in death as shown in figure (7) [48 -49].…”

Section: Anti-surface Coating For Coronavirusmentioning

confidence: 99%

ZnO nanoparticles and their properties as surface coating materials against coronavirus: viewpoint

Idriss¹,

Habib²,

Alakhras³

et al. 2022

JOBM

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A pandemic of coronavirus infection is causing a significant public health hazard globally, putting millions of people at risk in an increasing amount of countries. Nanostructured materials have been recognized to be highly efficient against coronaviruses. ZnO nanoparticles possess unique features that enable to act as anti-bacterial and anti-viral. Hence, the aim of the current investigation is to produce zinc oxide nanoparticles and utilized as surface coating materials against COVID-19. Thermal decomposition has been utilized in this investigation to fabricate ZnO nanoparticles with crystallite of 41 and 55 nm. The study outcomes demonstrated that Zinc nanoparticles is a favorable material for future usage as an anti-coronavirus surface due to their ecologically friendly features and exceptional physical and chemical functionality.

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In Vitro Determination of Inhibitory Effects of Humic Substances Complexing Zn and Se on SARS-CoV-2 Virus Replication

Cited by 12 publications

References 70 publications

The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers

The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers

Disinfection and decontamination in the context of SARS‐CoV‐2‐specific data

ZnO nanoparticles and their properties as surface coating materials against coronavirus: viewpoint

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