In-vitro digestion of curcumin loaded chitosan-coated liposomes

Cuomo, Francesca; Cofelice, Martina; Venditti, Francesco; Ceglie, Andrea; Miguel, Maria; Lindman, Björn; Lopez, Francesco

doi:10.1016/j.colsurfb.2017.11.047

Cited by 115 publications

(62 citation statements)

References 40 publications

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“…Nevertheless, Mix‐O/W nanoemulsions represent a suited solution to absorption because they allow the intake of a high amount of curcumin together with a low fat content. Additionally, this study constitute a further proof to the validation of the in vitro simulated digestion process, in accordance with recent study (Cuomo et al., ), for the obtainment of important results regarding the encapsulation of lipophilic compound such as curcumin within food‐grade delivery systems.…”

Section: Discussionsupporting

confidence: 87%

“…Gastrointestinal model : The gastrointestinal fate of curcumin‐loaded nanoemulsions was studied through an in vitro digestion model mimicking oral, gastric, and small intestinal phases (Cuomo et al., ; Versantvoort, Oomen, Van de Kamp, Rompelberg, & Sips, ). The simplified digestion process has been simulated by replicating the physiological digestive status of the various fluids (saliva, gastric and intestinal juices), including the residence time for each phase.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, these downsides may be overcome by encapsulating curcumin within food‐grade delivery systems such as liposomes (Chen et al., ), nanocomplexes (Chen, Li, & Tang, ), colloidosomes (Shah et al., ), emulsions (Aditya et al., ; Sari et al., ), nanoemulsions (Ahmed, Li, McClements, & Xiao, ; Patel & Velikov, ), or biopolymer nanoparticles (Hu et al., ; Xiao, Nian, & Huang, ). Among these strategies based on colloidal suspension for encapsulation and protection of compounds, the utilization of emulsions represents a good compromise to overcome the limits mentioned above (Cuomo et al., ; Cuomo, Ceglie, De Leonardis, & Lopez, ; Mosca, Murgia, Ceglie, Monduzzi, & Ambrosone, ). Nanoemulsions, in particular, are fine dispersions of oil droplet in water (Gurpreet & Singh, ) and are rapidly digested in the intestinal tract, thus, if the oil phase contains hydrophobic nutraceuticals, nanoemulsions can increase their bioavailability.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Enhanced Curcumin Bioavailability through Nonionic Surfactant/Caseinate Mixed Nanoemulsions

Cuomo

Perugini

Marconi

et al. 2019

Journal of Food Science

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The potential of heterogeneous systems like oil‐in‐water (O/W) nanoemulsions is exploited as an oral delivery system for curcumin, a natural lipophilic compound with numerous health benefits. Two types of O/W nanoemulsions, one stabilized by sodium caseinate (Cas‐O/W), a surface‐active and emulsifying protein, and the other stabilized by a blend of caseinate and Tween 20 (Mix‐O/W), were loaded with the bioactive compound and tested through a simulated gastrointestinal digestion process to evaluate their effects on delivering of curcumin. It was first demonstrated that the amount of curcumin solubilized through Mix‐O/W nanoemulsion was higher than that in Cas‐O/W nanoemulsion. Cas‐O/W nanoemulsions, indeed, at their best, solubilized about 55 µg/mL of curcumin while Mix‐O/W nanoemulsions reached a curcumin concentration around 180 µg/mL. Furthermore, for both the systems an increase of curcumin loading capacity was recorded with the rise of incubation temperature. Finally, after the in vitro simulated digestion process, the potential curcumin bioavailability was evaluated and the data suggested that Mix‐O/W nanoemulsions provided more than twice the amount of curcumin compared to Cas‐O/W nanoemulsions. On balance, the outcomes of this investigation demonstrated that the mixed emulsifier system offered a higher amount of lipophilic compound with a low fat intake compared to nanoemulsions stabilized by sodium caseinate. Practical Application The outcomes of this study allow the recognition of the protein/surfactant‐stabilized nanoemulsions as a suitable solution to deliver curcumin. The nanoemulsions proposed here provide a high intake of curcumin, a lipophilic compound, with low fat content. The use of such delivery systems helps to overcome limits in oral bioavailability related with the scarce solubility of some compounds in food preparations and beverages.

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Section: Discussionsupporting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhanced Curcumin Bioavailability through Nonionic Surfactant/Caseinate Mixed Nanoemulsions

Cuomo

Perugini

Marconi

et al. 2019

Journal of Food Science

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“…The diameter of the curcumin-loaded anionic liposomes (without chitosan) was 129 nm with a PdI of 0.095 and zeta potential of -49 mV. The diameter and PdI were not altered after chitosan coating, whereas the surface charge became positive [138]. Both formulations were tested in the in vitro digestion model, including simulated saliva fluid, simulated gastric fluid, and simulated intestinal fluid, and showed that liposomes without chitosan were digested slightly more in simulated saliva fluid and simulated gastric fluid, whereas chitosan-coated liposomes were more highly digested in simulated intestinal fluid.…”

Section: Nanocarriers For Curcumin Deliverymentioning

confidence: 95%

“…The presence of a positive charge on the chitosan-coated liposome surface results in an interaction with the negatively charged glycoproteins of mucin. This may result in their being covered by a layer of mucin and protection of the curcumin during the other phases of digestion, thus allowing greater curcumin absorption [138]. Solid lipid nanoparticles: solid lipid nanoparticles (SLNs) are another type of lipid-based nanocarrier.…”

Section: Nanocarriers For Curcumin Deliverymentioning

confidence: 99%

Improvement of Curcumin Bioavailability for Medical Applications

Her¹,

Venier-Julienne²,

Roger³

2018

Med Aromat Plants

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Nanoengineered Endocytic Biomaterials for Stem Cell Therapy

Wang,

Sun,

Liu

et al. 2024

Adv Funct Materials

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Stem cells, ideal for the tissue repair and regeneration, possess extraordinary capabilities of multidirectional differentiation and self‐renewal. However, the limited spontaneous differentiation potential makes it challenging to harness them for tissue repair without external intervention. Although conventional approaches using biomolecules, small organic molecules, and ions have shown specific and effective functions, they face challenges such as in vivo diffusion and degradation, poor internalization, and side effects on adjacent cells. Nanoengineered biomaterials offer a solution by solidifying and nanosizing these soluble regulating molecules and ions, facilitating their uptake by stem cells. Once inside lysosomes, these nanoparticles release their contents in a controlled “molecule or ion storm,” efficiently altering the intracellular biological and chemical microenvironment to tune the differentiation of stem cells. This newly emerged approach for regulating stem cell fate has attracted much attention in recent years. This method has shown promising results and is poised to enhance clinical stem cell therapy. This review provides an overview of the design principles for nanoengineered biomaterials, discusses the categories and characteristics of nanoparticles, summarizes the application of nanoparticles in tissue repair and regeneration, and discusses the direction of nanoparticle‐enhanced stem cell therapy and prospects for its clinical application in regenerative medicine.

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In-vitro digestion of curcumin loaded chitosan-coated liposomes

Cited by 115 publications

References 40 publications

Enhanced Curcumin Bioavailability through Nonionic Surfactant/Caseinate Mixed Nanoemulsions

Enhanced Curcumin Bioavailability through Nonionic Surfactant/Caseinate Mixed Nanoemulsions

Improvement of Curcumin Bioavailability for Medical Applications

Nanoengineered Endocytic Biomaterials for Stem Cell Therapy

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