In vitro effects of both dopaminergic and enkephalinergic antagonists on the ovarian growth of Cherax quadricarinatus (Decapoda, Parastacidae), at different periods of the reproductive cycle

Cahansky, Alejandra Valeria; Medesani, Daniel A.; Chaulet, Anouk; Rodríguez, Enrique M.

doi:10.1016/j.cbpa.2010.09.016

Cited by 15 publications

(15 citation statements)

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“…The synthesis and release of these neurohormones in crustaceans are believed to be regulated by biogenic amines (Richardson et al, ; Alfaro et al, ; Sainath and Reddy, ; Cahansky et al, ). Both serotonin (5‐HT) and dopamine (DA) are well‐known neurotransmitters in both vertebrates and invertebrates (Schenker et al, ; Aanesen et al, ; Alfaro et al, ; Sainath and Reddy, ; Yan et al, ).…”

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confidence: 99%

Effects of naloxone, serotonin, and dopamine on reproduction of the freshwater crabBarytelphusa guerini

Prasad

Naik

et al. 2013

J. Exp. Zool.

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Several investigators suggest a relationship between neurotransmitters, serotonin (also called 5-hydroxytryptamine, 5-HT), and dopamine (DA) in the regulation of growth and reproductive development of vertebrate species, rather than the invertebrate species. In this study, we evaluated the role of 5-HT and DA in reproductive development of an invertebrate species, the freshwater crab Barytelphusa guerini. We tested the effects of 5-HT both alone and combined, and also the effects of an opioid antagonist naloxone, on reproductive development of B. guerini in terms of testicular and ovarian developmental parameters. Injection of either 5-HT or naloxone alone significantly increased the ovarian index and the oocyte diameter in female crabs, and the testicular index and testicular follicular diameter in male crabs. In contrast, injection of DA inhibited all the reproductive measures in both sexes. Co-injection of 5-HT with DA exhibited no significant effects on the reproductive development in both sexes compared to the control treatments. These results suggest that 5-HT, DA, and exogenous naloxone may be involved in the regulation of gonad stimulating hormone (GSH) and/or gonad inhibiting hormone (GIH). These results also provide evidence that naloxone may regulate endogenous neurotransmitters and its downstream hormones, GSH and GIH.

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confidence: 99%

Effects of naloxone, serotonin, and dopamine on reproduction of the freshwater crabBarytelphusa guerini

Prasad

Naik

et al. 2013

J. Exp. Zool.

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“…The physiological context that allowed secondary vitellogenesis to occur [high levels of GSH and minimum levels of GIH (Adiyodi and Subramonian, ; Tsukimura, )] could have been associated with a low responsiveness of the thoracic ganglion to DA, owing to a possible downregulation of their receptors, or to any change in the intracellular signal transduction mechanism, as proposed by Cahansky et al . (). Under this possible physiological context of females from Group C, exogenous DA would have had no effect, independently of the dose administered.…”

Section: Discussionmentioning

confidence: 97%

“…An alternative explanation for the absence of DA effect on ovarian maturation of females from Group C is that the hormonal cascade that triggers secondary vitellogenesis could have been already induced at the onset of the experiment, with exogenous DA being unable to inhibit such process. The physiological context that allowed secondary vitellogenesis to occur [high levels of GSH and minimum levels of GIH (Adiyodi and Subramonian, 1983;Tsukimura, 2001)] could have been associated with a low responsiveness of the thoracic ganglion to DA, owing to a possible downregulation of their receptors, or to any change in the intracellular signal transduction mechanism, as proposed by Cahansky et al (2011). Under this possible physiological context of females from Group C, exogenous DA would have had no effect, independently of the dose administered.…”

Section: Discussionmentioning

confidence: 99%

“…; Cahansky et al . ). However, to our knowledge, the effects of long‐term administration of DA (through its injection) on the ovarian development of C. quadricarinatus have never been reported in the literature.…”

Section: Introductionmentioning

confidence: 97%

“…Moreover, the endocrine regulation of reproduction has been investigated, and endocrine manipulation of females (e.g. administration of methyl farnesoato, and dopaminergic and enkephalinergic antagonists) has been performed to improve ovarian growth and reproductive performance (Sagi et al 1997;Silkovsky et al 1998;Soroka et al 2000;Abdu et al 2001;Cahansky et al 2011). However, to our knowledge, the effects of long-term administration of DA (through its injection) on the ovarian development of C. quadricarinatus have never been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Effect of long‐term injection of dopamine on the ovarian growth of Cherax quadricarinatus juvenile females (Parastacidae, Decapoda)

Tropea

Greco

2012

Acta Zoologica

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The neurotransmitter dopamine (DA) modulates many physiological processes in decapod crustaceans, including reproduction. This study was aimed at evaluating whether the long‐term injection of DA affects ovarian growth in the freshwater crayfish Cherax quadricarinatus. Three experiments were performed with females of different mean initial size: 4.15 g (Group A); 9.65 g (Group B); and 13.98 g (Group C). Treated females were injected with DA and control females with physiological saline twice a week for 90 (Group B), 105 (Group A) and 120 (Group C) days. At the end of the experiments, the animals were killed, and the stage of ovarian development, gonadosomatic index, and mean oocyte diameter were determined. DA had a differential effect according to female size: it negatively affected ovarian growth of females in a weight range of 4–14 g and had no effect on ovarian maturation when injected to females with an initial weight of 14 g. The results are compared with previous reports in freshwater decapod crustaceans.

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Ovarian growth impairment after chronic exposure to Roundup Ultramax® in the estuarine crab Neohelice granulata

Canosa

Silveyra

Avigliano

et al. 2017

Environ Sci Pollut Res

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Adult females of the estuarine crab Neohelice granulata were exposed to the glyphosate formulation Roundup Ultramax® during the entire 3-month pre-reproductive period. At the end of the assay, a significant higher increment of glycemia was noted at both glyphosate concentrations assayed (0.01 and 0.2 mg/L, acid equivalent). Although no differences were observed in the gonadosomatic index, a significantly higher proportion of reabsorbed vitellogenic oocyte was observed at the highest glyphosate concentration, together with a significant decrease of vitellogenin content in the ovary. In addition, some in vitro assays were carried out by co-incubating small pieces of ovary with or without the addition of Roundup; at both concentrations tested (same as those used in vivo), a decrease in the ovarian vitellogenin content was observed, whereas the ovarian protein synthesis was significantly inhibited by glyphosate at 0.2 mg/L in the Roundup formulation used.

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In vitro effects of both dopaminergic and enkephalinergic antagonists on the ovarian growth of Cherax quadricarinatus (Decapoda, Parastacidae), at different periods of the reproductive cycle

Cited by 15 publications

References 30 publications

Effects of naloxone, serotonin, and dopamine on reproduction of the freshwater crabBarytelphusa guerini

Effects of naloxone, serotonin, and dopamine on reproduction of the freshwater crabBarytelphusa guerini

Effect of long‐term injection of dopamine on the ovarian growth of Cherax quadricarinatus juvenile females (Parastacidae, Decapoda)

Ovarian growth impairment after chronic exposure to Roundup Ultramax® in the estuarine crab Neohelice granulata

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