In vitro effects of oil's fatty acids on T cell function in gestational diabetic pregnant women and their newborns 油类脂肪酸在体外对妊娠期糖尿病孕妇及其新生儿的T细胞功能的影响

Abstract

Linseed, olive and Nigel oils had beneficial effects on T cell functions in gestational diabetes.

<i>In Vitro </i>Effects of Oil’s Fatty Acids on T-Cell Function of Obese Men

“…We observed that in the presence of linseed and Nigel oils, the T cell oxidant markers, MDA and carbonyl proteins were reduced in obese patients, probably as a consequence of enhanced antioxidant defense. These results are in agreement with previous reports on antioxidant effects of linseed and Nigel oils [21].…”

“…Dietary n-3 PUFAs promote apoptosis in a T cell subset exhibiting a Th1 cytokine profile, affecting T cell proinflammatory function [19]. N-3 PUFA improved T cell intracellular oxidative status in diabetes and in gestational diabetes [20] [21]. α-linolenic acid (ALA, C18:3 n-3) is an important n-3 PUFA supplied by vegetable sources such as linseed oil.…”

“…To mimic human consumption, we have used these oils in spite of purified fatty acids and we have investigated their effects on immune function. We have previously shown that they have modulatory effects on in vitro lymphocyte function during gestational diabetes [21]. However, their effects on immune function during obesity remained to be discovered.…”

Oleic acid enhances the motility of umbilical cord blood derived mesenchymal stem cells through EphB2-dependent F-actin formation

“…Of those two, OA is the most abundant form of a monounsaturated omega-9 fatty acid (C18:1 cis-9) that is produced by stearoyl CoA desaturase 1 (SCD1), mainly from stearic acid (C18:0) by catalyzing Δ9 desaturation [5]. Moreover, OA has been recognized as an effective biomolecule because it causes MSCs to secrete angiogenic mediators and regulates immunomodulatory functions [4,6,7]. Though the significance of OA with regard to the modulation of stem cell functions has been recognized, the mechanism by which OA mediates beneficial physiological effects at the intracellular signaling level has not been completely described.…”

The effects ofn-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomised, double-blind, placebo-controlled trial

“…Similar to our findings, Zhao & Wang (34) found that n-3 fatty acids applied as a part of parenteral nutrition in postoperative patients with gastrointestinal malignancy decreased CRP and other inflammatory markers. An in vitro study demonstrated that peripheral blood lymphocytes of women with GDM when exposed to n-3 fatty acids caused elevated GSH and decreased MDA cell levels (35) . A 12-week n-3 fatty acid supplementation with 2 g/d flaxseed oil improved hs-CRP and GSH levels in patients with grade 3 diabetic foot ulcer (36) .…”