In vitro effects of ozone on human erythrocyte membranes: an EPR study.

Górnicki, Albert; Gutsze, A.

doi:10.18388/abp.2000_3951

Cited by 32 publications

(10 citation statements)

References 36 publications

(36 reference statements)

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“…The problem of tissue hypoxia and impaired perfusion in chronic infection seems to be equally important. A study conducted by Polish researchers demonstrated the usefulness of ozone therapy in regulating blood supply to tissues [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial

Nardi

Cesarano

Papa

et al. 2020

IJERPH

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Background: Extracellular matrix metalloproteinases (MMPs) play a pivotal role in the damage to the periodontal tissue in patients with periodontitis. Scaling and root planning (SRP) attempt to control the plaque amount and consequentially reduce the bacterial load. Non-surgical periodontal treatment could be integrated with drug therapy and physiotherapy procedures such as ozone therapy. The aim of this study was to evaluate in a cohort of patients with a diagnosis of periodontitis: (1) the efficacy of non-surgical periodontal therapy assisted by the use of ozonated olive oil-based mouthwash on salivary metalloproteinase (MMP-8) and (2) the reduction of periodontal indices. Methods: Ninety-six subjects with a diagnosis of periodontitis were enrolled in this study and randomly assigned to the study group (SRP + mouthwash) or control group (SRP). The study duration was 3 months. Data on MMP-8, plaque index (PI), bleeding on probing (BoP) and probing pocket depth (PPD) were recorded at T0, T1 (14 days), T2 (1 month) and T3 (6 months). Group differences were assessed using Student’s t-test for independent samples. Results: A significant improvement in PI, BoP, PPD and salivary MMP-8 levels was observed in both groups. An analysis of differences in relative changes of indices revealed the efficacy of ozonated olive oil in decreasing MMP-8 level. Simultaneously, it slowed the decrease of BoP index. Conclusions: Scaling and root plaining with the aid of ozonated olive oil mouthwash were found to be more effective on salivary MMP-8 reduction than scaling and root plaining alone.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial

Nardi

Cesarano

Papa

et al. 2020

IJERPH

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“…Moreover, the dynamics of the mitochondrial membrane was studied at different levels. The order parameters 5 NS and 16 NS, assessed membrane viscosity at the polar head or at the hydrophilic portion, respectively (Gornicki and Gutsze ). As shown in Table , the 5 NS and 16 NS markers were elevated in diabetic groups so that the fluidity was decreased in ZDF fa/fa rats.…”

Section: Discussionmentioning

confidence: 99%

Liver mitochondrial function in ZDF rats during the early stages of diabetes disease

et al. 2016

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The aim of this study was to characterize the early alterations of the liver mitochondrial function in ZDF (fa/fa) rats that develop diabetes compared to that of their lean counterparts ZDF (fa/+). Liver mitochondrial function was examined in 11‐ and 14‐week‐old ZDF (fa/fa) and ZDF lean (fa/+) rats. Oxygen consumption, H2O2 release, calcium retention capacity (CRC), membrane potential, membrane fluidity, and fatty acid composition were analyzed. State 3 oxygen consumption with palmitoyl‐carnitine increases between 11 and 14 weeks of age in lean but not in diabetic animals. This response was not seen with other substrates, suggesting that the use of fatty acids is impaired in diabetic rats. H2O2 release was lower in 14‐week‐old ZDF (fa/fa) rats as compared to ZDF lean (fa/+). These changes were not associated with differences in enzymatic activities of the respiratory complexes, suggesting regulatory mechanisms independent of their expression levels. Membrane fluidity and composition analyses show only slight effects linked to diabetes progression. The most salient feature was a reduction in CRC in the presence of CsA, an effect reflecting PTP dysregulation. Our data suggest few changes of mitochondrial function in ZDF fa/fa rats. At the age of 11 weeks, liver mitochondria have mainly a reduced effect of CsA on CRC.

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“…16 NS experimentations: The changes in freedom motion of 16 NS were analyzed with the calculation of τ c , the rotational correlation time. τ c was calculated following the formula: [14] …”

Section: Methodsmentioning

confidence: 99%

Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect?

Debouzy

Crouzier

Lefèbvre

et al. 2008

Drug Target�Insights

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Shark liver oil (SLO), is used in natural medicine as immunity stimulant, cardiovascular protector and anti ageing reagent. These properties were related with the high amounts of alkylglycerols (22%) obtained from Greenland shark liver. After a control of the mean SLO composition by NMR and MS, surface and membrane interactions and antioxidant properties were investigated using NMR, ESR and ST measurements and the in vitro consequences on erythrocytes and cells were studied. An estimation of the composition of this extract was performed. Moreover, SLO was found not haemolytic (A concentration inducing 50% haemolysis, HC 50 could not be reached) and superfi cial tension measurements revealed slight tension active properties. The 31 P and 2 H-NMR and ESR studies of phospholipid dispersions (dimyristoyl phosphatidyl cholin, DMPC) in the presence of SLO showed a signifi cant increase in membrane fl uidity at low temperature (below phase transition temperature) predominantly observed at the surface level. The anti oxidant activity was also confi rmed, similar as that observed for vitamin E.

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In vitro effects of ozone on human erythrocyte membranes: an EPR study.

Cited by 32 publications

References 36 publications

Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial

Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial

Liver mitochondrial function in ZDF rats during the early stages of diabetes disease

Study of Alkylglycerol Containing Shark Liver Oil: A Physico Chemical Support for Biological Effect?

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