In vitro effects of substance P and arginine-vasopressin on testosterone production in Leydig cells of short and long photoperiodic hamsters

Angelova, P.; Davidoff, M; Bakalska, Mariana; Kanchev, L.N.

doi:10.1111/j.1439-0272.1996.tb02809.x

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…In mammals, SP expression can be located in Leydig cells within the testis (e.g., in rat) (Lasaga and Debeljuk, 2011) and SP treatment in vitro inhibits both basal (Angelova et al, 1991) and LH-induced testosterone production in Leydig cell culture (e.g., in hamster) (Angelova et al, 1996). However, it is still unclear if NKB is also expressed in Leydig cells, and to our knowledge, the functional role of NKB in steroid production has not been examined at the gonad level.…”

Section: Expression and Functions Of Nkb In The Gonadmentioning

confidence: 99%

Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish

Lin

et al. 2014

General and Comparative Endocrinology

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In mammals, neurokinin B (NKB), the gene product of the tachykinin family member TAC3, is known to be a key regulator for episodic release of luteinizing hormone (LH). Its regulatory actions are mediated by a subpopulation of kisspeptin neurons within the arcuate nucleus with co-expression of NKB and dynorphin A (commonly called the "KNDy neurons"). By forming an "autosynaptic feedback loop" within the hypothalamus, the KNDy neurons can modulate gonadotropin-releasing hormone (GnRH) pulsatility and subsequent LH release in the pituitary. NKB regulation of LH secretion has been recently demonstrated in zebrafish, suggesting that the reproductive functions of NKB may be conserved from fish to mammals. Interestingly, the TAC3 genes in fish not only encode the mature peptide of NKB but also a novel tachykinin-like peptide, namely NKB-related peptide (or neurokinin F). Recent studies in zebrafish also reveal that the neuroanatomy of TAC3/kisspeptin system within the fish brain is quite different from that of mammals. In this article, the current ideas of "KNDy neuron" model for GnRH regulation and steroid feedback, other reproductive functions of NKB including its local actions in the gonad and placenta, the revised model of tachykinin evolution from invertebrates to vertebrates, as well as the emerging story of the two TAC3 gene products in fish, NKB and NKB-related peptide, will be reviewed with stress on the areas with interesting questions for future investigations.

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Section: Expression and Functions Of Nkb In The Gonadmentioning

confidence: 99%

Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish

Lin

et al. 2014

General and Comparative Endocrinology

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“…The involvement of tachykinins in the regulation of mammalian testicular function has already been reviewed (236,244,245), and the text below is a brief summary. SP inhibits testosterone production and release by isolated Leydig cells in hamster (246,247). Tac1, tac3, and tac4 genes are expressed in the human sperm (248).…”

Section: Mammalsmentioning

confidence: 99%

Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts

2022

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In vertebrates, the tachykinin system includes tachykinin genes, which encode one or two peptides each, and tachykinin receptors. The complexity of this system is reinforced by the massive conservation of gene duplicates after the whole-genome duplication events that occurred in vertebrates and furthermore in teleosts. Added to this, the expression of the tachykinin system is more widespread than first thought, being found beyond the brain and gut. The discovery of the co-expression of neurokinin B, encoded by the tachykinin 3 gene, and kisspeptin/dynorphin in neurons involved in the generation of GnRH pulse, in mammals, put a spotlight on the tachykinin system in vertebrate reproductive physiology. As food intake and reproduction are linked processes, and considering that hypothalamic hormones classically involved in the control of reproduction are reported to regulate also appetite and energy homeostasis, it is of interest to look at the potential involvement of tachykinins in these two major physiological functions. The purpose of this review is thus to provide first a general overview of the tachykinin system in mammals and teleosts, before giving a state of the art on the different levels of action of tachykinins in the control of reproduction and food intake. This work has been conducted with a comparative point of view, highlighting the major similarities and differences of tachykinin systems and actions between mammals and teleosts.

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Peptidergic Innervation of Blood Vessels and Interstitial Cells in the Testis of the Cat

Suburo

Chiocchio

Soler

et al. 2002

Journal of Andrology

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ABSTRACT:We studied the innervation of the cat testis using a panel of antisera against the following neuronal markers: protein gene product 9.5 (PGP), neuropeptide Y, C-terminal peptide of neuropeptide Y, galanin, vasoactive intestinal peptide (VIP), calcitonin gene-related peptide, and substance P. Immunoreactivity against PGP, a general neuronal label, demonstrated the arrangement of fibers from the superior spermatic nerve (SSN) in the testicular pedicle and the cephalic testicular pole, and those of the inferior spermatic nerve (ISN) along the vas deferens and the inferior testicular ligament. The testicular parenchyma exhibited a very rich innervation, mainly distributed to blood vessels and Leydig cell nests, but also in close association with seminiferous tubules. Numerous peptidergic fibers were present in the SSN and ISN, albeit in different proportions. Thus, VIP-immunoreactive fibers were almost absent in the SSN, but were the most abundant subpopulation of the ISN. The testicular interstitium contained numerous peptidergic fibers, associated with blood vessels, interstitial Leydig cells, and seminiferous tubules. Similar fibers were related to the rete testis. Parenchymatous VIP-immunoreactive nerves disappeared after bilateral vasectomy. Stimulation of the ISN under experimental conditions was associated with an increase of blood flow, and induced a large release of VIP into the spermatic vein. The extensive and selective distribution of nerve fibers within the cat testicular parenchyma supports the importance of spermatic nerves for testicular function. Furthermore, the differences in the fiber composition of the SSN and ISN can be correlated with their opposing effects on testosterone secretion and testicular blood flow.

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In vitro effects of substance P and arginine-vasopressin on testosterone production in Leydig cells of short and long photoperiodic hamsters

Cited by 7 publications

References 36 publications

Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish

Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish

Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts

Peptidergic Innervation of Blood Vessels and Interstitial Cells in the Testis of the Cat

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