In vitro evaluation of a pH-sensitive hydrogel for control of GI drug delivery from silicone-based matrices

A fast pH-responsive IPN hydrogel: Synthesis and controlled drug delivery

“…The human body exhibits variations of pH along the gastrointestinal tract, and also in some specific areas like certain tissues (and tumoral areas) and subcellular compartments. Hydrogels containing ionizable groups can take advantage of their ability to volume changes depending on the pH of the physiological medium [6][7][8][9][10][11]. Poly(methacrylic acid) (PMAA) is a typical acidic hydrophilic polymer and widely used in drug delivery systems.…”

Smart Nanohydrogels for Controlled Release of Food Preservatives

“…Para ello 12 ENFOQUE, JUSTIFICACIÓN Y OBJETIVOS el primer subobjetivo es la evaluación de la efectividad antimicrobiana en sistemas modelo basados en placas de agar contaminadas con un microorganismo indicador y almacenadas en condiciones favorables y desfavorables para la estabilidad química de la pimaricina con el fin de evaluar el efecto protector del nanohidrogel. El segundo subobjetivo es la evaluación de la efectividad antimicrobiana en un alimento real con el fin de controlar la contaminación de quesos de la DOP Arzúa-Ulloa almacenados bajo diferentes condiciones de térmicas simulando una rotura en la cadena de frío.…”

Investigation of pH-dependent swelling behavior and kinetic parameters of novel poly(acrylamide-co-acrylic acid) hydrogels with spirulina

“…For this reason, they swell only at certain pH values; these hydrogels are also called "pH-dependent swelling hydrogels" or "pH-sensitive gels". This property of weak polyelectrolyte hydrogels makes them suitable for a number of applications, in particular for drug delivery applications (14)(15)(16)(17)(18)(19)(20). In these applications, cationic hydrogels with basic groups are chosen for swelling, leading to the release of a drug at low pH value, like in the stomach, whereas they collapse at high pH values.…”