“…These complicated defects require a triad of tissue engineering, cells, signaling molecules, and a scaffold. Fibrin is a natural scaffold that has been used clinically to promote bone regeneration due to its outstanding biocompatibility, manageable biodegradability, and ability to deliver signaling molecules [ 1 , 2 ]. Fibrin proteins can be obtained from pooled plasma, which can be promptly used, but can transmit viruses, or a patient’s own plasma, which is safe and biocompatible; however, obtaining it from the patient may be painful and requires multistep preparation [ 3 ].…”