2019
DOI: 10.1016/j.jds.2018.08.010
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In vitro evaluation of local antibiotic delivery via fibrin hydrogel

Abstract: Background/purpose Fibrin hydrogel is commonly used as hemostatic agent and scaffold but it is questionable for carrying antibiotics. Thus, this study aimed to investigate whether the fibrin hydrogel can be used to deliver the optimal concentration of ciprofloxacin against oral pathogen. Materials and methods The optimal concentration of ciprofloxacin was investigated from broth microdilution technique against three common oral bacteria. Ten times the bactericidal conce… Show more

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Cited by 19 publications
(13 citation statements)
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“…23 It may also be a result of the microstructure of the fibrin hydrogel which could allow for a better diffusion of the antibiotic through the meshwork. 54 Indeed, the agar diffusion assay clearly displayed that CLIN-PLA-NPs progressively released from the hydrogel efficiently inhibited E. faecalis growth, in a similar way to 50 mg mL À1 free CLIN incorporated into the hydrogel. This result demonstrates that CLIN-PLA-NPs maintain their activity upon incorporation within the nanocomposite hydrogel.…”
Section: Discussionmentioning
confidence: 87%
“…23 It may also be a result of the microstructure of the fibrin hydrogel which could allow for a better diffusion of the antibiotic through the meshwork. 54 Indeed, the agar diffusion assay clearly displayed that CLIN-PLA-NPs progressively released from the hydrogel efficiently inhibited E. faecalis growth, in a similar way to 50 mg mL À1 free CLIN incorporated into the hydrogel. This result demonstrates that CLIN-PLA-NPs maintain their activity upon incorporation within the nanocomposite hydrogel.…”
Section: Discussionmentioning
confidence: 87%
“…These complicated defects require a triad of tissue engineering, cells, signaling molecules, and a scaffold. Fibrin is a natural scaffold that has been used clinically to promote bone regeneration due to its outstanding biocompatibility, manageable biodegradability, and ability to deliver signaling molecules [ 1 , 2 ]. Fibrin proteins can be obtained from pooled plasma, which can be promptly used, but can transmit viruses, or a patient’s own plasma, which is safe and biocompatible; however, obtaining it from the patient may be painful and requires multistep preparation [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…The not well-established usage of antibiotics can lead to the progression of resistance. The use of two or three different antibiotics in a combination can be more effective in treatment [ 2 , 3 ] and local application of the selected antibiotics may increase the effectiveness as it can be up to 100-fold higher administered in the therapeutic doses compared with the systemic usage [ 4 , 5 ].…”
Section: Introductionmentioning
confidence: 99%