In vitro evaluation of osteoconductivity and cellular response of zirconia and alumina based ceramics

Pandey, Akash; Pati, Falguni; Mandal, Debika; Dhara, Santanu; Biswas, Koushik

doi:10.1016/j.msec.2013.05.032

Cited by 29 publications

(17 citation statements)

References 27 publications

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“…The cell adhesion and proliferation rate was significantly higher on the zirconia surface than on the titanium surface, but there was no difference in the synthesis of bone-specific proteins. Pandey et al 42) reported that the stabilizer of zirconia maybe an influencing factor for its biocompatibility. The ceria stabilized zirconia probably reduce the biological activity compared to yttria stabilized zirconia.…”

Section: Discussionmentioning

confidence: 99%

The surface characterization and bioactivity of NANOZR in vitro

et al. 2014

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The purpose of this study was to evaluate the surface characterization and bioactivity of ceria-stabilized zirconia/alumina nanocomposite (NANOZR) in comparison to yttria-stabilized zirconia (3Y-TZP) and pure titanium (CpTi). Three-dimension surface morphology, surface wettability, bovine serum albumin adsorption rate, cell morphology, cell proliferation and ALP activity of three tested materials were measured. There were no significant differences in surface roughness, contact angle among the three materials. The ALP expression of NANOZR was higher than CpTi and 3Y-TZP at 14 and 21 days although bovine serum albumin adsorption rate, cell morphology; and cell proliferation was not different among the three materials. These results suggest that the three test materials basically had similar surface characterization and bioactivity. Within the limitations of this study, our results show that the three test materials were biologically similar bio-inert materials.

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Section: Discussionmentioning

confidence: 99%

The surface characterization and bioactivity of NANOZR in vitro

et al. 2014

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“…In bulk‐nanostructured zirconia, the tetragonal structure may also reach desirable optical properties if the grain size is small enough to make any birefringence effect negligible (Alaniz et al, ; Zhang, Messing, & Borden, ). To reduce the energy configuration of cubic or tetragonal zirconia and hence reduce the energy required to synthesize the material, zirconia may be doped with other ceramic phases like yttria, ceria, or alumina (Gliga, Skoglund, Wallinder, Fadeel, & Karlsson, ; Pandey, Pati, Mandal, Dhara, & Biswas, ). The dopant phase synthetically creates oxygen vacancies in the zirconia crystal structure, and the resulting lattice‐strain reduces the energy configuration of tetragonal and cubic phases (Kwon et al, ).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and cytocompatibility of yttria stabilized zirconia nanopowders for creating a window to the brain

Rutherford

Exarhos

et al. 2019

J Biomed Mater Res

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Transparent cranial window to the brain is highly desirable for brain therapies because such cranial implant would allow for continuous monitoring of brain disorders and long‐term delivery of photodynamic therapy into the brain without repeated surgeries for opening skull. Nanostructured yttria‐stabilized zirconia (YSZ) is a potential candidate for the window to the brain application because of its promising mechanical and optical properties. In this study, a new process using aerosol spray pyrolysis was established for synthesizing 6–7 nm YSZ nanopowders with precisely controlled compositions. YSZ nanopowders with 3 M ratios of yttria to zirconia, specifically 3, 6, and 8% yttria in zirconia (referred to as 3YSZ, 6YSZ, and 8YSZ, respectively) were synthesized and characterized. The size, structure, and composition of the produced YSZ nanoparticles are highly controllable and scalable. The in vitro cytocompatibility of the YSZ nanoparticles with bone marrow mesenchymal stem cells (BMSCs) was investigated using a direct exposure culture method for cranial implant applications. Nondoped ZrO2 and commercially available 8YSZ (named as C_8YSZ) served as controls for the in vitro cell studies. BMSCs exhibited normal morphology when cultured with the YSZs of 3 M ratios in the concentrations of 10 mM, 30 mM, and 60 mM, as well as ZrO2 and C_8YSZ controls. The BMSCs cultured with 3YSZ and 6YSZ showed no statistical differences in cell adhesion density when compared with the ZrO2 and C_8YSZ controls at respective concentrations of 10–60 mM. The possible release of YSZ nanoparticles from cranial window implants should be carefully considered and further studied.

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“…The peak at 371 • C corresponds to the onset of Al 2 O 3 crystallization removal of surface (NH 3 and water) and lattice (CO 3 and water) followed by crystallization of Al 2 O 3 at 548 • C [29]. Similarly, the peaks at 681 and 900 • C favour HAp crystallization process, whereas the peaks at 961 and 1146 • C indicate the secondary reactions between HAp and Al 2 O 3 [30,31]. This result clearly illustrates the calcination process at 900 • C (<1000 • C) is effective for the formation of HAp−Al 2 O 3 composite without any interfacial reactions.…”

Section: Dscmentioning

confidence: 98%

“…The prepared nanocomposites are analysed for in vitro cytotoxicity activity using MTT assay against MG63 human osteoblast-like cell lines, which exhibits similar adhesiveness and physiology as that of human osteoblasts cells [31] figure 8b. Thus, MTT assay clearly indicates that the prepared nanocomposite is highly compatible for orthopaedic applications.…”

Section: Cytotoxicity Studymentioning

confidence: 99%

Synthesis and characterization of hydroxyapatite/alumina ceramic nanocomposites for biomedical applications

Raj

Rajkumar²,

Sundaram³

et al. 2018

Bull Mater Sci

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In the present work, nanocrystalline hydroxyapatite/alumina (HAp−Al 2 O 3) composite was prepared under specially designed stir-type hydrothermal reactor. The composite was prepared at two different temperatures under autogenous pressure and analysed for crystallinity, size, shape, composition and thermomechanical stability. The electron microscopy study shows the formation of HAp−Al 2 O 3 composite nanorods with uniform distribution. The thermogravimetry analysis reveals better thermomechanical property with minimal weight loss at increased temperature. The effect of different concentrations of HAp−Al 2 O 3 composite powders against MG63 human osteosarcoma cell lines shows excellent compatibility (80%) at high concentration of 200 μg ml −1. These studies facilitate the formation of biocompatible HAp−Al 2 O 3 composite nanorods for biomedical applications.

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In vitro evaluation of osteoconductivity and cellular response of zirconia and alumina based ceramics

Cited by 29 publications

References 27 publications

The surface characterization and bioactivity of NANOZR in vitro

The surface characterization and bioactivity of NANOZR in vitro

Synthesis, characterization, and cytocompatibility of yttria stabilized zirconia nanopowders for creating a window to the brain

Synthesis and characterization of hydroxyapatite/alumina ceramic nanocomposites for biomedical applications

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