In vitro evaluation of the therapeutic potential of Anatolian kermes oak (Quercus coccifera L.) as an alternative wound healing agent

Anlaş, Ceren; Bakırel, Tülay; Alkan, Fulya Üstün; Çelik, Baran; Baran, Merve Yüzbaşıoğlu; Üstüner, Oya; Kuruüzüm-Uz, Ayşe

doi:10.1016/j.indcrop.2019.05.008

Cited by 25 publications

(14 citation statements)

References 51 publications

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“… 25 However, today, there are many agents that can be used to accelerate wound healing, but these are derived from chemicals that have the potential to create adverse side effects and often come at a monetary cost. 26 Therefore, new substances capable of accelerating the wound healing process are still needed. Wound healing requires a complex process in which keratinocytes, fibroblasts, endothelial cells, macrophages, and platelets have their own roles to play.…”

Section: Discussionmentioning

confidence: 99%

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Arundina

Diyatri

Surboyo

et al. 2021

Journal of Taibah University Medical Sciences

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Objective The healing process of a traumatic ulcer requires growth factors to rebuild the lost tissue after the inflammatory process has been completed. Liquid rice hull smoke (LR-HS) has shown unique anti-inflammatory properties. This study analyses the role of LR-HS in growth factor stimulation for the healing of traumatic ulcers, such as fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and collagen type 1 (COL-1) expression. Methods We obtained LR-HS from the pyrolysis of rice hulls. Traumatic ulcers were created in the labial fornix incisive inferior of Wistar rats and treated with LR-HS once a day for 3, 5, and 7 days. The control group was treated with sterile water. Each animal was sacrificed after treatment, and its labial fornix incisive inferior tissues were biopsied and immunohistochemically stained to examine FGF, VEGF, PDGF, and COL-1 expression. Result The treatment of traumatic ulcers with LR-HS showed an increase in FGF, VEGF, PDGF, and COL-1 expression. VEGF expression increased under LR-HS treatment compared with the control 7-day treatment groups ( p < 0.000). FGF and COL-1 expression increased under LR-HS treatment compared with the control 5- and 7-day treatment groups ( p < 0.000). PDGF expression increased after treatment with LR-HS for 3, 5, and 7 days ( p < 0.000). Conclusion This study has demonstrated that LR-HS can induce the expression of growth factors during the healing of a traumatic ulcer using immunohistochemical staining. We suggest that LR-HS can be used as a herbal medicine for oral ulcer therapy.

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Section: Discussionmentioning

confidence: 99%

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Arundina

Diyatri

Surboyo

et al. 2021

Journal of Taibah University Medical Sciences

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“…In this context, plants are regarded as a good source for various phytoconstituents, and these are assimilated more easily, as compared to synthetic drugs, by both humans and animals. Traditional treatment alternatives, especially plant-based compounds are recognized as easily accessible treatment options that eliminate the disruptions associated with modern treatment methods [9,10]. Within this context, World Health Organization (WHO) recommends and encourages the use of plant-based treatments, which have been known as safe and effective [11].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial and Wound Healing Potential of Thymus Sipyleus Boiss. Subsp. Rosulans (Borbas) Jalas

et al. 2019

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Thymus sipyleus Boiss. subsp. rosulans (Borbas) Jalas (TS) is a commonly used plant in the treatment of various complaints, including skin wounds in Turkish folk medicine. Despite the widespread traditional use of TS, there is not any scientific report confirming the effectiveness of this plant on the healing process. This research aimed to investigate the effects of different extracts obtained from TS on biological events during wound healing, on a cellular basis. In this context, proliferative activities of the extracts, as well as the effects on wound closure and hydroxyproline synthesis, were determined. In addition to wound healing properties, the antioxidant, antibacterial and anti-inflammatory activities of the extracts were evaluated. Decoction (D) and infusion (I) extracts contained the highest amount of phenolic content and showed the most potent activity against DPPH radical. All extracts exhibited complete protection against the damage induced by hydrogen peroxide (H2O2) by increasing cell viability compared to only H2O2-treated groups, both in co-treatment and pre-treatment protocols. None of the extracts exhibited cytotoxic activity, and most of the extracts from the TS stimulated fibroblast proliferation and migration. All TS extracts exert anti-inflammatory activity by suppressing the overproduction of tumor necrosis factor-alpha (TNF-α) and nitric oxide (NO). The most pronounced activity on hydroxyproline synthesis was observed in D extract. In summary, it was observed that TS extracts can promote the healing process by enhancing fibroblast migration, proliferation and collagen synthesis as well as suppressing pro-inflammatory cytokines. The obtained data in this work support the traditional use of TS as a valuable plant-based compound for the treatment of wounds.

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“…Evaluation of Quercus in HT-29 cells showed a decrease in the levels of the inflammatory markers COX-2 and IL-8 by modulating the expression of NF- κ B [ 31 ]. The other in vitro studies confirmed the reduction of inflammatory cytokines and inhibition of lipopolysaccharide-induced production of TNF- α [ 32 ].…”

Section: Introductionmentioning

confidence: 74%

The Antioxidant and Anti-Inflammatory Effects of Quercus brantii Extract on TNBS-Induced Ulcerative Colitis in Rats

Naini

Mehrvarzi

Zargari-Samadnejadi

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objectives. Ulcerative colitis is a common subtype of persistent inflammatory bowel disease with high morbidity consequences. Despite unknown definite pathogenesis, multiple anti-inflammatory medications are used for its treatment. Traditionally, Quercus brantii (QB), mostly available in the Middle East, has been used for gastrointestinal disorders. Other beneficial effects associated with QB include reduction of oxidative stress, inflammations, homeostatic instability, and improvement in clinical conditions. Materials and Methods. This experimental study was designed to assess the possible therapeutic effects of QB on UC and compare its effects with those of sulfasalazine. Of the 70 Wistar rats clustered in seven groups, ten received only alcohols and sixty were confirmed to be suffering from trinitrobenzene sulfonic acid- (TNBS-) induced colitis. Four groups received different dosages of QB extract via oral and rectal routes, one received sulfasalazine, and the other remaining two groups received nothing. The effects of QB were evaluated by assessing macroscopic and histologic scoring, measuring inflammatory mediators, and determining oxidative stress markers. Results. Comparing to the untreated TNBS-induced control groups, QB-treated groups showed a dose- and route-dependent improvement comparable with sulfasalazine. Treating rats with QB reduced the microscopic and macroscopic damage, decreased TNF-α, IL-6, NO, MPO activity, and MDA content, increased superoxide dismutase (SOD) activity, and reduced body weight loss. Conclusions. Our data recommended the anti-inflammatory and antioxidant effects of QB extract in a dose-dependent manner.

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In vitro evaluation of the therapeutic potential of Anatolian kermes oak (Quercus coccifera L.) as an alternative wound healing agent

Cited by 25 publications

References 51 publications

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

Growth factor stimulation for the healing of traumatic ulcers with liquid rice hull smoke

In Vitro Evaluation of Antioxidant, Anti-Inflammatory, Antimicrobial and Wound Healing Potential of Thymus Sipyleus Boiss. Subsp. Rosulans (Borbas) Jalas

The Antioxidant and Anti-Inflammatory Effects of Quercus brantii Extract on TNBS-Induced Ulcerative Colitis in Rats

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