In vitro evaluation of the ZX11 magnesium alloy as potential bone plate: Degradability and mechanical integrity

Hou, Ruiqing; Victoria-Hernández, José; Jiang, Pingli; Willumeit‐Römer, Regine; Luthringer-Feyerabend, Bérengère; Yi, Sangbong; Letzig, Dietmar; Feyerabend, Frank

doi:10.1016/j.actbio.2019.07.053

Cited by 94 publications

(43 citation statements)

References 69 publications

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“…The TRC ZMA611 alloy exhibits larger fracture elongation than ingot cast AZ31 alloy at all testing temperatures and strain rates, which is caused by the presence of thermally stable Al 8 Mn 5 dispersoid particles. Hou et al [225] have compared the degradability and mechanical integrity of a TRC Mg0.7Zn0.6Ca alloy (in wt.%) before and after annealing. The results show that the residual strain and deformation twins restored in the as-rolled alloy lead to a slightly higher corrosion rate than that of the annealed one.…”

Section: Twin-roll Castingmentioning

confidence: 99%

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

Jiang

Blawert

Zheludkevich

2020

CMD

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Magnesium alloys have shown great potential for applications as both structural and biomedical materials due to their high strength-to-weight ratio and good biodegradability and biocompatibility, respectively. Among them, Mg-Zn based alloys are attracting increasing interest for both applications. As such, this article provides a review of the corrosion performance and mechanical properties of Mg-Zn based alloys, including the influence of environment and processing on both of them. The strategies for tailoring corrosion resistance and/or mechanical properties by microstructure adjustment and surface treatment are discussed.

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Section: Twin-roll Castingmentioning

confidence: 99%

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

Jiang

Blawert

Zheludkevich

2020

CMD

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“…It is remarkable to mention that every manufacturing process that decelerates the rate of degradation of Mg alloys can significantly enhance the mechanical integrity of Mg‐based biomaterials. For instance, Hou et al 102 . evaluated the mechanical integrity of the rolled and the annealed ZX11 Mg alloys via tensile test after immersion assay.…”

Section: Challenges Of Mg‐based Biomaterialsmentioning

confidence: 99%

Biodegradable magnesium‐based biomaterials: An overview of challenges and opportunities

Amukarimi

Mozafari

2021

MedComm

125

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As promising biodegradable materials with nontoxic degradation products, magnesium (Mg) and its alloys have received more and more attention in the biomedical field very recently. Having excellent biocompatibility and unique mechanical properties, magnesium‐based alloys currently cover a broad range of applications in the biomedical field. The use of Mg‐based biomedical devices eliminates the need for biomaterial removal surgery after the healing process and reduces adverse effects induced by the implantation of permanent biomaterials. However, the high corrosion rate of Mg‐based implants leads to unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. To overcome these limitations, alloying Mg with suitable alloying elements and surface treatment come highly recommended. In this area, open questions remain on the behavior of Mg‐based biomaterials in the human body and the effects of different factors that have resulted in these challenges. In addition to that, many techniques are yet to be verified to turn these challenges into opportunities. Accordingly, this article aims to review major challenges and opportunities for Mg‐based biomaterials to minimize the challenges for the development of novel biomaterials made of Mg and its alloys.

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“…After the removal of corrosion products, the sample surfaces were cleaned by vigorous shaking in distilled water and 100 pct ethanol. The mean degradation depth (h) of corroded samples in lm was then calculated using the following equation [47,48] :…”

Section: B Immersion Testmentioning

confidence: 99%

Effects of Intermetallic Microstructure on Degradation of Mg-5Nd Alloy

Zhang

Huang

Feyerabend

et al. 2020

Metall Mater Trans A

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The influence of intermetallic microstructure on the degradation of Mg-5Nd alloy with different heat treatments was investigated via immersion testing in DMEM + 10 pct FBS under cell culture conditions and subsequent microstructural characterizations. It was found that T4 heat-treated sample had the poorest corrosion resistance due to the lack of finely dispersed precipitates inside grains, continuous lamellar particles along grain boundaries and outer Ca-P layer, and to the formation of a loose corrosion product layer. In contrast, the aged samples exhibited a better corrosion resistance due to their presence and to the formation of a compact corrosion layer. Their degradation behavior largely depended on the intermetallic microstructure. Corrosion was initiated in the matrix around stable globular particles Mg41Nd5 at grain boundaries. In the sample aged at high temperature 245 °C, the coexistence of lamellar Mg41Nd5 particles and their nearby Nd-poor regions enhanced the corrosion. The corrosion first started in such regions. It was shown that those finely dispersed precipitates formed during aging had no influence on the corrosion initiation. However, they indeed affected the subsequent corrosion propagation with the immersion proceeding. They supplied barriers for corrosion propagation and hence were beneficial for improving the corrosion resistance. The continuously distributed lamellar Mg41Nd5 precipitates formed at grain boundaries during aging at 245 °C supplied an additional effective obstacle to corrosion propagation. This was especially beneficial for hindering the corrosion propagation at the later stage of corrosion.

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In vitro evaluation of the ZX11 magnesium alloy as potential bone plate: Degradability and mechanical integrity

Cited by 94 publications

References 69 publications

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

Biodegradable magnesium‐based biomaterials: An overview of challenges and opportunities

Effects of Intermetallic Microstructure on Degradation of Mg-5Nd Alloy

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