2006
DOI: 10.1016/j.joen.2005.10.031
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In Vitro Evaluation of the Antimicrobial Effects of a Root Canal Sealer-Antibiotic Combination Against Enterococcus faecalis

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Cited by 54 publications
(59 citation statements)
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“…Local antibiotics offer an advantage as systemic consequences and complications are prevented and substantially higher concentrations can be utilized. 6 Cariology Research Unit of Niigata University School of Dentistry developed the concept of lesion sterilization and tissue repair (LSTR) therapy that employs a mixture of antibacterial drugs for disinfection. 3 …”
Section: Discussionmentioning
confidence: 99%
“…Local antibiotics offer an advantage as systemic consequences and complications are prevented and substantially higher concentrations can be utilized. 6 Cariology Research Unit of Niigata University School of Dentistry developed the concept of lesion sterilization and tissue repair (LSTR) therapy that employs a mixture of antibacterial drugs for disinfection. 3 …”
Section: Discussionmentioning
confidence: 99%
“…Historically, two different assays have been used to test the antimicrobial properties of sealers: the agar diffusion test (ADT) and the direct contact test (DCT). Hoelscher et al (20) used the ADT to determine the effect of different antibiotics mixed with a ZOE-based sealer on Enterococcus faecalis. Hoelscher et al found a significant difference in the zone of inhibition with fresh sealer mixed with amoxicillin compared with sealer without amoxicillin.…”
mentioning
confidence: 99%
“…No obstante, se ha reportado que cuando se administra un antibiótico de forma sistémica, solo una pequeña parte de la concentración del fármaco alcanza el conducto radicular, lo que lo hace poco benéfico. Frente a lo anterior, la aplicación de antibióticos locales permite administrar concentraciones sustancialmente más elevadas y evitar complicaciones sistémicas (Hoelscher et al, 2006). El manejo de la evidencia anteriormente descrita, ha permitido que desde varios años en la Clínica Integral de la Especialidad en Odontopediatría de la Universidad Autónoma de Zacatecas, se instaure el tratamiento endodóntico no instrumentado en dientes primarios, mediante uso de una pasta antibiótica que contiene la mezcla de fármacos antibacterianos para la desinfección de órganos dentales con afectación pulpar y pronostico dudoso.…”
Section: Discussionunclassified