In vitro evaluation of topical gel prepared using natural polymer.

Kumar, Lalit; Verma, Ruchi

doi:10.5138/ijdd.2010.0975.0215.02012

Cited by 105 publications

(71 citation statements)

References 9 publications

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“…Tarik kaca bulat sebelah atas dengan beban 80 g. Jarak dan waktu yang dibutuhkan untuk memisahkan kedua kaca dicatat. Daya sebar dihitung dengan persamaan (1) 15 . Nilai ∆daya sebar diperoleh dengan menghitung selisih daya sebar antara basis gel yang disterilisasi dan yang tidak disterilisasi.…”

Section: Uji Daya Sebarunclassified

Pengaruh Suhu Dan Durasi Sterilisasi Metode Panas Kering Terhadap Viskositas Dan Daya Sebar Basis Gel Alginat

Putri

Dwiastuti

Tuliani

2017

PJI

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Kata kunci : daya sebar, gel alginat, sterilisasi, suhu, viskositas A B S T R A K Alginat merupakan polimer alami yang dapat digunakan dalam sediaan penutup luka. Sediaan penutup luka harus steril sehingga tidak menimbulkan infeksi tambahan pada luka. Proses sterilisasi dapat mempengaruhi sifat fisik sediaan yang terkait dengan penerimaan pasien. Penelitian ini bertujuan untuk mengetahui pengaruh suhu dan durasi sterilisasi metode panas kering terhadap viskositas dan daya sebar basis gel alginat. Gel alginat disterilisasi dengan berbagai variasi suhu dan durasi kemudian diuji sifat fisiknya yang meliputi sterilitas, penampilan, viskositas, dan daya sebar. Selisih (∆) nilai viskositas dan daya sebar basis alginat yang disterilisasi dan yang tidak disterilisasi kemudian dianalisis menggunakan uji Kruskal-Wallis (∆viskositas) dan ANAVA (∆daya sebar). Hasil penelitian ini menunjukkan bahwa suhu dan durasi sterilisasi mempengaruhi organoleptis, viskositas dan daya sebar basis gel alginat. Semakin tinggi suhu dan lama durasi sterilisasi akan menyebabkan perubahan warna menjadi lebih gelap, menurunkan viskositas dan meningkatkan daya sebar basis gel alginat, yang ditunjukkan dengan meningkatnya nilai ∆viskositas dan ∆daya sebar secara signifikan. Suhu terendah dan durasi terpendek dengan perubahan penampilan, viskositas, dan daya sebar basis gel alginat paling rendah adalah sterilisasi pada suhu 130 o C selama 120 menit.. Effect Of Temperature And Duration Of Dry Heat Sterilization Method On Viscosity And Spreadability Of Alginate-Based GelKeywords: alginat gel, spreadability, sterization, viscosity A B S T R A C TAlginate is a natural polymer which can be used in preparation of wound dressing. Wound dressing preparation should be sterile so it would not cause additional infection into the wound. Sterilization process can affect the physical properties associated with patient's acceptability. The aim of this study was to examine the effect of sterilization temperature and duration using dry heat method to viscosity and spreadability of alginate-based gel. Alginate-based gel that has been sterilized with variation of temperature and duration were characterized for the sterility, viscosity and spreadability. The difference (∆) value of viscosity and spreadability alginate-based gel, with and without sterilization was tested using Kruskal-Wallis test (for ∆ viscosity) and ANOVA (for ∆ spreadability). The result showed that sterilization temperature and duration affect the appearance, viscosity and spreadability of alginate-based gel. Higher temperature and duration of heating will decrease viscosity and increase spreadability of alginate-based gel, indicated by the increased value of the ∆ viscosity and ∆ spreadability.

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Section: Uji Daya Sebarunclassified

Pengaruh Suhu Dan Durasi Sterilisasi Metode Panas Kering Terhadap Viskositas Dan Daya Sebar Basis Gel Alginat

Putri

Dwiastuti

Tuliani

2017

PJI

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“…The extruded gel volume was measured based on the spilled water. 10 method was used to measure bioadhesive properties of the gel. The pig's large intestine was used to represent the mucous-like texture of a fresh wound.…”

Section: Methodsmentioning

confidence: 99%

“…Extrudability study. The modified of Kumar and Verma (2010) 10 method was used to measure extrudability properties of the gel. This test was used to determine the force required to extrude gel from the tube.…”

Section: Methodsmentioning

confidence: 99%

Untitled

2012

IJPSR

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Binahong (Anredera cordifolia (Ten) Steenis) has been used as wound healing in traditional Indonesian medicine and it is relevant to develop dosage forms of binahong using formulation technology approach. The aim of this research was to find out wound healing gel formula of ethanolic extract of binahong. The factorial design method 3 factors and 2 levels were employed to achieve this study. Three factors used in this study were Carbopol, Na-CMC and Caalginate with low and high level for each factor. The wound healing gel of ethanolic extract of binahong was evaluated for their physical properties i.e viscosity, spreadability, extrudability and bioadhesive properties. The results of this research were carbopol and Ca-alginate affecting physical properties of wound healing gel of ethanolic extract of binahong. Na-CMC affected physical properties of the gel except bioadhesive properties. Carbopol provided the greatest contribution to viscosity, spreadability, extrudability and bioadhesive properties of the gel.

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“…When dispersed in an appropriate solvent, gelling agents form a colloidal network structure. 9,10 Lipophilic and hydrophilic drugs can be entrapped in proniosomes either in aqueous layer or in vesicular membrane, which produced chemically and physically stable vesicles having low toxicity because of their non-ionic nature .…”

Section: Introductionmentioning

confidence: 99%

Development of Proniosomal Gel: in-vitro, ex-vivo and in-vivo Characterization

Farooqui¹,

Kar²,

Singh³

et al. 2017

IJPER

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The aim of the present research work was to characterize the ex-vivo, in-vitro and in-vivo studies of proniosomal (PN) gel of ketorolac tromethamine (KT). Experimental work: Proniosomal suspension was prepared by rotatory flask evaporator with addition of nonionic surfactant (Sodium Cholate) at concentration ranges (3%, 2% and 1%). Co-solvent like isopropanol, butanol and ethanol as well as dimethyl sulphoxide (DMSO), was later added which act as permeability enhancers in gel formulations. Carbopol 940 was added as the gelling agent in proniosomal suspension. Characterization: PN gel acts as percutaneous enhancers on the transdermal permeability hence were investigated for ex-vivo (Franz Diffusion Cell), in-vitro (Membrane Diffusion Technique) and in-vivo (Estimation of KT in serum at different time intervals by RP-HPLC) studies. Effect of KT on acute inflammation was evaluated in rat carrageenan-induced edema model. Results: Proniosomal gel formulation F1 consisting of sodium cholate, isopropanol and soya lecithin, showed highest drug release of 94.048 % in 24 hrs and formulation F9 showed lowest drug release of 73.789 % in 16 hrs. Transdermal flux (J) of formulation F1 was found to be high (7.518±0.041µg/cm 2 .hr) as compared to other formulations and marketed preparation. Proniosomal formulation (F1), consisting of sodium cholate (concentration 3%) and cosolvent (isopropanol) attained highest penetrability effect, where sodium cholate and isopropanol induced significant changes in membrane permeability as they completely solubilised membrane phospholipids by sodium cholate micelles. In case of F1 formulation, percent inhibition was found to be 66.84%. Serum estimation of Ketorolac Tromethamine (KT) revealed that application of F1formulation produced 4-fold increase in peak plasma concentration within 12 hours and was maintained upto 24 hours as compared to marketed formulation. Eventually a significant in-vitro-in-vivo correlation was achieved and PN formulation of KT shows significant improvement in bioavailability of KT in systemic circulation when applied via topical route as compared to marketed gel preparation.

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In vitro evaluation of topical gel prepared using natural polymer.

Cited by 105 publications

References 9 publications

Pengaruh Suhu Dan Durasi Sterilisasi Metode Panas Kering Terhadap Viskositas Dan Daya Sebar Basis Gel Alginat

Pengaruh Suhu Dan Durasi Sterilisasi Metode Panas Kering Terhadap Viskositas Dan Daya Sebar Basis Gel Alginat

Untitled

Development of Proniosomal Gel: in-vitro, ex-vivo and in-vivo Characterization

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