In vitro exposure to mercury and cadmium alters term human placental membrane fluidity

Boadi, William Y.; Urbach, Jacob; Brandes, Joseph M.; Yannai, S.

doi:10.1016/0041-008x(92)90139-j

Cited by 31 publications

(13 citation statements)

References 35 publications

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“…Animal data are also in agreement with human observations (Gale & Ferm, 1971;Gale & Hanlon, 1976;Gale, 1981;Holt & Webb, 1986). It has been recently reported that exposure of human placental cells to mercury caused the accumulation of metal in the membranes and lowered the membrane fluidity (Boadi et al, 1992). Inorganic mercury can also be excreted into the mammary gland (Berlin, 1979;Oskarsson et al, 1995).…”

Section: Discussionsupporting

confidence: 77%

Mercury Content in Skin-Lightening Creams and Potential Hazards to the Health of Saudi Women

Al‐Saleh¹,

Al-Doush²

1997

Journal of Toxicology and Environmental Health

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It seems evident from a wealth of scientific research that mercury is toxic. Because of the nature of the Saudi markets, different brands of skin-lightening creams are widely available. In this study, 38 skin-lightening cream samples were collected and analyzed for mercury by inductively coupled plasma spectrometry after an acid digestion procedure. About 45% of the tested skin-lightening cream samples contained mercury at levels well above the FDA's acceptable limit of 1 ppm. These findings are alarming and have wide legal and educational implications for Saudi Arabia in particular and developing countries in general. Further investigation for possible adverse health effects is also needed.

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Section: Discussionsupporting

confidence: 77%

Mercury Content in Skin-Lightening Creams and Potential Hazards to the Health of Saudi Women

Al‐Saleh¹,

Al-Doush²

1997

Journal of Toxicology and Environmental Health

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“…Animal data are also in agreement with human observations (Gale & Ferm, 1971;Gale & Hanlon, 1976;Gale, 1981;Holt & Webb, 1986). It has been recently reported that exposure of human placental cells to mercury caused the accumulation of metal in the membranes and lowered the Downloaded by [Chulalongkorn University] at 03:16 27 December 2014 membrane fluidity (Boadi et al, 1992). Inorganic mercury can also be excreted into the mammary gland (Berlin, 1979;Oskarsson et al, 1995).…”

Section: Discussionsupporting

confidence: 75%

Mercury Content in Skin-Lightening Creams and Potential Hazards to the Health of Saudi Women

Al‐Saleh

Al-Doush

1997

Journal of Toxicology and Environmental Health

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“…Mercury toxicity in placenta includes disturbed amino acid transfer, placental oxygen consumption, enzyme activity, hormonal secretion, and membrane fluidity [53][54][55][56]. Lead interferes with calcium uptake of the syncytiotrophoblast [57].…”

Section: Placental Toxicodynamics Of Mercury Lead and Cadmiummentioning

confidence: 99%

The role of the placenta in fetal exposure to heavy metals

Gundacker

Hengstschläger

2012

Wien Med Wochenschr

226

123

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The heavy metals mercury, lead, and cadmium are toxicants, which are well-known to cross the placenta and to accumulate in fetal tissues. Prenatal exposure to mercury and lead poses a health threat particularly to the developing brain. Fetal exposures to lead and cadmium correlate with reduced birth weight and birth size. The placental passage of cadmium is limited suggesting a partial barrier for this metal. It is very likely that metallothionein is responsible for placental storage of the metals especially of cadmium. It is unclear, however, which proteins are involved in placental uptake and efflux of the metals and where the transporters are located at the placental barrier. Hence, only certain aspects of placental metal toxicokinetics are known so far. The metals have also been shown to adversely affect placental functions. Both metal-specific placental transfer and impairment of placental function can explain the relationships between prenatal metal exposures and adverse effects on intrauterine growth and (neuro)development.

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In vitro exposure to mercury and cadmium alters term human placental membrane fluidity

Cited by 31 publications

References 35 publications

Mercury Content in Skin-Lightening Creams and Potential Hazards to the Health of Saudi Women

Mercury Content in Skin-Lightening Creams and Potential Hazards to the Health of Saudi Women

Mercury Content in Skin-Lightening Creams and Potential Hazards to the Health of Saudi Women

The role of the placenta in fetal exposure to heavy metals

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