In vitro fertilization at a public hospital in Nigeria

Orhue, Aae; Aziken, ME; Osemwenkha, Abieyuwa P.; Ibadin, Kennedy; Odoma, Gabriel

doi:10.1016/j.ijgo.2012.01.022

Cited by 18 publications

(20 citation statements)

References 19 publications

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“…The main findings of the current study were that the number of eggs retrieved, fertilized ovum, the number of embryos successfully transferred and the rate of successful induction of pregnancy depend on age of the woman and endometrial thickness. The pregnancy rate (20.9%) in this study was lower than the rates recently reported in Nigeria (30%; Orhue et al , 2012 ); Tunisia (32.4%; Fourati et al , 2009 ), Vienna, Austria (27.3%; Nouri et al , 2015 ) and in Singapore ( Tan et al , 2014 ). It is worth mentioning, however, that all of these studies (with exception of Fourati et al ) report the pregnancy rate following IVF/ICSI and not the rate following ICSI alone, as in our study.…”

Section: Discussioncontrasting

confidence: 77%

Maternal age and intracytoplasmic sperm injection outcome in infertile couples at Khartoum, Sudan

Ahmed

Shareef²,

Adam

2015

F1000Res

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Background Intracytoplasmic sperm injection (ICSI) was considered as the mainstay of treatment for male infertility. Nowadays, the scope of ICSI has been widened to include other causes of infertility. There are few published data on ICSI in countries with low incomes. Aims A cross-sectional study was conducted at Saad AbuAlla and Banoun Centers, Khartoum, Sudan to investigate outcomes of ICSI and to determine the parameters that might predict pregnancy success rate following ICSI. Methods The study included 191 infertile couples who underwent 296 ICSI cycles between 1st April 2013 and 31 March 2014. Results One hundred and ninety one couples (comprising 296 cycles of ICSI) were enrolled to the study. The mean (SD) number of retrieved oocytes was 9.7 (7.5). The mean (SD) number of transferred embryos was 2.9 (1.0). Out of these, 50 (26.2%) and 40 (20.9%) had chemical and clinical pregnancy, respectively. Thirty–six couples (18.8%) and five couples (2.6%) had miscarriage and had ectopic pregnancy, respectively. Under logistic regression, younger age (OR = 0.8, 95% CI= 0.81 ─ 0.96, P = 0.004) and endometrial thickness (OR = 1.3, 95% CI= 1.07─1.60, P = 0.009) were the significant predictors for the success of ICSI in inducing pregnancy. Conclusion The rates of successful fertilisation and pregnancy-to-term rates in this setting depend mainly on the maternal age.

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Section: Discussioncontrasting

confidence: 77%

Maternal age and intracytoplasmic sperm injection outcome in infertile couples at Khartoum, Sudan

Ahmed

Shareef²,

Adam

2015

F1000Res

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“…Despite the fact that the first IVF centre in Nigeria was established in the eighties 10 the cost is still prohibitive. A single IVF treatment costs around US$2500 but the minimum wage is just US$52.60 a month, therefore the average person cannot afford this option 11 . However Orhue et al recommended that treating the patients in batches may lower the cost of IVF for the individual patient 12 .…”

Section: Discussionmentioning

confidence: 99%

Association between history of abdominopelvic surgery and tubal pathology

Famurewa¹,

Adeyemi²,

Ibitoye³

et al. 2013

Afr H. Sci.

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Background: Pelvic infection, unsafe abortion and previous laparatomy are risk factors for tubal infertility among Nigerian women. Reports on the relationship between these factors and tubal pathology seen on hysterosalpingography (HSG) from our environment have been few. Objective: To assess the prevalence of tubal occlusions among patients referred for HSG and examine the association between previous history of abdominopelvic surgery (including dilatation and curettage for abortion) and tubal occlusion. Methods: We studied one hundred and thirty women referred to the Radiology department for HSG because of infertility. HSG was performed during the early proliferative phase of the menstrual cycle. Information about type and duration of infertility, history of abdomino -pelvic surgery and history suggestive of previous pelvic infection, were obtained from the patients. The data obtained were analyzed using SPSS version 11.Test of association using the chi-square test was done where appropriate and differences were considered at p= 0.05. Results: Sixty one women had bilaterally patent tubes; tubal pathology was seen in sixty nine women. Significant association exits between tubal pathology and history of pelvic surgery p=0.01, pelvic infection p=0.02 and duration of infertility p=0.04. Conclusion: Previous surgery especially dilation and curettage, PID duration and type of infertility are associated with tubal pathology among Nigerian women. Creative methods of lowering the cost of diagnosis and management of tubal occlusion need to be instituted.

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“…Spontaneous reduction in 47.7% of multiples. Average of three embryos transferred.Orhue et al (2012)Case note review to determine outcomes of ART.CPR 30.0%, MPR 20.0% b . Up to three embryos/transfer.…”

Section: Resultsmentioning

confidence: 99%

Availability, effectiveness and safety of ART in sub-Saharan Africa: a systematic review

Botha

Shamley

Dyer

2018

Human Reproduction Open

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STUDY QUESTION What is the evidence pertaining to availability, effectiveness and safety of ART in sub-Saharan Africa? SUMMARY ANSWER According to overall limited and heterogeneous evidence, availability and utilization of ART are very low, clinical pregnancy rates largely compare to other regions but are accompanied by high multiple pregnancy rates, and in the near absence of data on deliveries and live births the true degree of effectiveness and safety remains to be established. WHAT IS KNOWN ALREADY In most world regions, availability, utilization and outcomes of ART are monitored and reported by national and regional ART registries. In sub-Saharan Africa there is only one national and no regional registry to date, raising the question what other evidence exists documenting the status of ART in this region. STUDY DESIGN, SIZE, DURATION A systematic review was conducted searching Pubmed, Scopus, Africawide, Web Of Science and CINAHL databases from January 2000 to June 2017. A total of 29 studies were included in the review. The extracted data were not suitable for meta-analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS The review was conducted according to Preferred Reporting Items for Systematic Reviews (PRISMA) guidelines. All peer-reviewed manuscripts irrespective of language or study design that presented original data pertaining to availability, effectiveness and safety of ART in sub-Saharan Africa were eligible for inclusion. Selection criteria were specified prior to the search. Two authors independently reviewed studies for possible inclusion and critically appraised selected manuscripts. Data were analysed descriptively, being unsuitable for statistical analysis. MAIN RESULTS AND THE ROLE OF CHANCE The search yielded 810 references of which 29 were included based on the predefined selection and eligibility criteria. Extracted data came from 23 single centre observational studies, two global ART reports, two reviews, one national data registry and one community-based study. ART services were available in 10 countries and delivered by 80 centres in six of these. Data pertaining to number of procedures existed from three countries totalling 4619 fresh non-donor aspirations in 2010. The most prominent barrier to access was cost. Clinical pregnancy rates ranged between 21.2% and 43.9% per embryo transfer but information on deliveries and live births were lacking, seriously limiting evaluation of ART effectiveness. When documented, the rate of multiple pregnancy was high with information on outcomes similarly lacking. LIMITATIONS, REASONS FOR CAUTION The findings in this review are based on limited data from a limited number of countries, and are derived from heterogeneous studies, both in terms of study design and quality, many of which include small sample sizes. Although representing best available e...

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In vitro fertilization at a public hospital in Nigeria

Abstract: Successfully conducting an assisted reproduction program at a public health facility is feasible in a low-resource country. Treating couples in batches was cost effective, with a low complication rate.

Cited by 18 publications

References 19 publications

Maternal age and intracytoplasmic sperm injection outcome in infertile couples at Khartoum, Sudan

Maternal age and intracytoplasmic sperm injection outcome in infertile couples at Khartoum, Sudan

Association between history of abdominopelvic surgery and tubal pathology

Availability, effectiveness and safety of ART in sub-Saharan Africa: a systematic review

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