In Vitro Functional Properties of the Rat Bladder Regenerated by the Bladder Acellular Matrix Graft

Piechota, Hans J.; Dahms, Stefan E.; Nunes, Lora; Dahiya, Rajvir; Lue, Tom F.; Tanagho, Emil A.

doi:10.1097/00005392-199805000-00100

Cited by 158 publications

(63 citation statements)

References 44 publications

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“…Collagenbased and biodegradable materials have also been shown to have regenerative and functional capacities and a bladder acellular matrix graft has been claimed to be successful for augmentation cytoplasty in the rat model leading to structural and functional regeneration of detrusor smooth muscle [568] including contractile activity to electrical field stimulation showing responses to muscarinic, purinergic and adrenergic agonists [557].…”

Section: Bladder Graftsmentioning

confidence: 99%

Purinergic signalling in the urinary tract in health and disease

Burnstock

2013

Purinergic Signalling

143

149

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Purinergic signalling is involved in a number of physiological and pathophysiological activities in the lower urinary tract. In the bladder of laboratory animals there is parasympathetic excitatory cotransmission with the purinergic and cholinergic components being approximately equal, acting via P2X1 and muscarinic receptors, respectively. Purinergic mechanosensory transduction occurs where ATP, released from urothelial cells during distension of bladder and ureter, acts on P2X3 and P2X2/3 receptors on suburothelial sensory nerves to initiate the voiding reflex, via low threshold fibres, and nociception, via high threshold fibres. In human bladder t h e p u r i n e rg i c c o m p o n e n t o f p a r a s y m p a t h e t i c cotransmission is less than 3 %, but in pathological conditions, such as interstitial cystitis, obstructed and neuropathic bladder, the purinergic component is increased to 40 %. Other pathological conditions of the bladder have been shown to involve purinoceptor-mediated activities, including multiple sclerosis, ischaemia, diabetes, cancer and bacterial infections. In the ureter, P2X7 receptors have been implicated in inflammation and fibrosis. Purinergic therapeutic strategies are being explored that hopefully will be developed and bring benefit and relief to many patients with urinary tract disorders.

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Section: Bladder Graftsmentioning

confidence: 99%

Purinergic signalling in the urinary tract in health and disease

Burnstock

2013

Purinergic Signalling

143

149

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“…21,22 Native normal bladder tissue retrieved from animals with no-operation was used for normal control. After the retrieve, all the bladders were immediately placed in an ice-cold Krebs-Henseleit buffer (Sigma-Aldrich) and opened along the lateral edges.…”

Section: Muscle Tissue Contractilitymentioning

confidence: 99%

Coadministration of Platelet-Derived Growth Factor-BB and Vascular Endothelial Growth Factor with Bladder Acellular Matrix Enhances Smooth Muscle Regeneration and Vascularization for Bladder Augmentation in a Rabbit Model

Zhou

Yang²,

Sun³

et al. 2013

Tissue Engineering Part A

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“…[22][23][24][25] Transplantation of mesenchymal progenitor cells into damaged bladder has also been attempted, and the importance of scaffolds as a microenviroment has been emphasized. 26 Acellular ECM grafts were attempted for bladder tissue engineering from the early period of regenerative medicine.…”

Section: Bladdermentioning

confidence: 99%

Regenerative medicine as a new therapeutic strategy for lower urinary tract dysfunction

Sumino

Mimata

2013

Int J of Urology

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Abbreviations & AcronymsAbstract: The use of regenerative medicine for the treatment of organic and functional disorders intractable to conventional treatment has increased worldwide. This innovative medical field might particularly hold promise for the treatment of lifethreatening diseases or healing of irreplaceable organs, such as the heart, liver and brain. Dysfunction of the urogenital tract and associated organs other than the kidney might not have immediate life-threatening implications; furthermore, the effectiveness of alternative therapy, such as enterocystoplasty for bladder cancer, has been shown. Therefore, most physicians or scientists do not give much importance to these disorders. However, urological disease has increased in developed societies in recent years. Furthermore, medical costs have also escalated. Disorders of the lower urinary tract, such as urinary disturbance or incontinence, can lead to other complications, impairing quality of life and ultimately increasing short-and long-term medical expenses. Regenerative medicine might hold potential solutions to these problems. Recent advances in urogenital regenerative medicine are reviewed in the present article, with particular reference to lower urinary tract reconstruction. The potential of regenerative medicine for the treatment of intractable lower urinary tract dysfunction compared with conventional treatment is also discussed.

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In Vitro Functional Properties of the Rat Bladder Regenerated by the Bladder Acellular Matrix Graft

Abstract: The present study provides further evidence that augmentation cystoplasty with the BAMG leads to functional regeneration of the rat bladder detrusor smooth muscle.

Cited by 158 publications

References 44 publications

Purinergic signalling in the urinary tract in health and disease

Purinergic signalling in the urinary tract in health and disease

Coadministration of Platelet-Derived Growth Factor-BB and Vascular Endothelial Growth Factor with Bladder Acellular Matrix Enhances Smooth Muscle Regeneration and Vascularization for Bladder Augmentation in a Rabbit Model

Regenerative medicine as a new therapeutic strategy for lower urinary tract dysfunction

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