In Vitro Gene Delivery with Large Porous Silicon Nanoparticles Fabricated Using Cost‐Effective, Metal‐Assisted Chemical Etching

Abstract

The cytocompatibility, cell membrane affinity, and plasmid DNA delivery from surface oxidized, metal-assisted stain-etched mesoporous silicon nanoscale particles (pSiNPs) to human embryonic kidney (HEK293) cells is demonstrated, suggesting the possibility of using such material for targeted transfection and drug delivery.

Tailoring Porous Silicon for Biomedical Applications: From Drug Delivery to Cancer Immunotherapy

“…Much work has also been focused on PSi‐based particulate drug delivery systems, which can be ascribed to their wide applicability and relative ease of fabrication as well as administration . PSi particles are being assessed for biomedical applications,[4c,g,13b,26a,45] and some of them have already been tested in clinical trials by pSiMedica Ltd, UK (pSivida Corp, USA) . The loading of small drug molecules, peptides, proteins, genetic materials, and even nanoparticles in PSi has already been successfully demonstrated, and they showed promising therapeutic effects in the therapy of diseases such as cancer,[13d,48] diabetes,[13b,49] heart diseases, wound healing, and immunotherapy.…”

Crystallographically Determined Etching and Its Relevance to the Metal-Assisted Catalytic Etching (MACE) of Silicon Powders

“…Nanostructured silicon has attracted significant interest for targeted delivery of multiple compounds in a theranostic setting (Salonen et al, 2008; Santos et al, 2011; Santos and Hirvonen, 2012). Porous silicon (por-Si) particles have been studied intensively for sustained release of drugs and used successfully to carry a wide variety of payloads from small-molecule drugs to therapeutic biomolecules, such as peptides, siRNA and DNA (Kaukonen et al, 2007; Anglin et al, 2008; Kilpeläinen et al, 2009; Ashley et al, 2011) as well as genes (Wareing et al, 2017). Nanostructured Si plays an increasingly important role in energy conversion and storage devices (Aricò et al, 2005; Kamat, 2007; Hochbaum and Yang, 2010; Micheli et al, 2013; Han et al, 2014; Mai et al, 2014).…”

Nano-Modified Titanium Implant Materials: A Way Toward Improved Antibacterial Properties

“…The methods of this kind of synthesis include self assembly ( Zhang et al, 2019b ; Deng et al, 2020 ), laser pyrolysis ( Laurent et al, 2010 ; Dumitrache et al, 2019 ), condensation ( Sano et al, 2020 ), CVD ( Gutés et al, 2012 ; Tyurikova et al, 2020 ), sol-gel method ( Gonçalves, 2018 ), soft lithography ( Fu et al, 2018 ), hydrothermal methods ( Zhen et al, 2019 ; Moreira et al, 2020 ), microwave methods ( Henam et al, 2019 ), sonochemical ( Gupta and Srivastava, 2019 ; Moreira et al, 2020 ), synthesis using plant extracts ( Ogunyemi et al, 2019 ; Ranoszek-Soliwoda et al, 2019 ), and green synthesis ( Gour and Jain, 2019 ; Irshad et al, 2020 ). On the other hand, macroscopic level materials can be trimmed down to NPs by different methods, including mechanical grinding ( Sviridov et al, 2017 ; Haque et al, 2018 ), ball milling ( Li Y. et al, 2020 ), lithography ( Fu et al, 2018 ), vapor deposition ( Choi et al, 2018 ), arc-plasma deposition ( Ito et al, 2012 ; Takahashi et al, 2015 ), ion beam technique ( Heo and Gwag, 2014 ; Yang J. et al, 2018 ), severe plastic deformation ( Cui et al, 2018 ; Sarkari Khorrami et al, 2019 ), chemical etching ( Wareing et al, 2017 ; Pinna et al, 2020 ), sputtering ( Pišlová et al, 2020 ), and laser ablation ( Pandey et al, 2014 ; Abid et al, 2020 ).…”