In Vitro Growth and Differentiation of Osteoblast-Like Cells on Hydroxyapatite Ceramic Granule Calcified From Red Algae

Turhani, Dritan; Cvikl, Barbara; Watzinger, Elisabeth; Weißenböck, Martina; Yerit, Kaan; Thurnher, Dietmar; Lauer, Günter; Ewers, Rolf

doi:10.1016/j.joms.2005.02.015

Cited by 50 publications

(32 citation statements)

References 22 publications

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“…Among modern biomaterials, bioceramics (calcium phosphate and hydroxyapatite) are very promising candidates in bone substitution, because of their bone-like chemical composition and mechanical properties [1][2][3][4]6,8,[10][11][12][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

“…Calcium phosphate and hydroxyapatite ceramics are considered among the most promising bone substitutes [1][2][3][4]6,8,[10][11][12][19][20][21][22], because of their bonelike chemical composition and mechanical properties. Hydroxyapatite ceramics, in particular, are used in orthopaedics, maxillofacial and dental implant surgery, either alone or in combination with other substances or materials.…”

Section: Introductionmentioning

confidence: 99%

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Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics

et al. 2006

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“…The culture of chondrocytes and osteoblasts on neat electrospun PCL fibers has also been reported 5,9. In addition, many researchers have reported that incorporation of calcium carbonate (CaCO 3 ) or a type of calcium phosphate such as hydroxyapatite (HA) helped to improve osteoblast proliferation and differentiation 9–12…”

Section: Introductionmentioning

confidence: 98%

Preparation and Characterization of Novel Bone Scaffolds Based on Electrospun Polycaprolactone Fibers Filled with Nanoparticles

Wutticharoenmongkol¹,

Sanchavanakit²,

Pavasant³

et al. 2005

Macromolecular Bioscience

232

129

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Novel bone-scaffolding materials were successfully fabricated by electrospinning from polycaprolactone (PCL) solutions containing nanoparticles of calcium carbonate (CaCO(3)) or hydroxyapatite (HA). The diameters of the as-spun fibers were found to increase with the addition and increasing amounts of the nanoparticles. The observed increase in the diameters of the as-spun fibers with the addition and increasing amounts of the nanoparticulate fillers was responsible for the observed increase in the tensile strength of the obtained fiber mats. An increase in the concentration of the base PCL solution caused the average diameter of the as-spun PCL/HA composite fibers to increase. Increasing applied electrical potential also resulted in an increase in the diameters of the obtained PCL/HA composite fibers. Lastly, indirect cytotoxicity evaluation of the electrospun mats of PCL, PCL/CaCO(3), and PCL/HA fibers based on human osteoblasts (SaOS2) and mouse fibroblasts (L929) revealed that these as-spun mats posed no threat to the cells, a result that implied their potential for utilization as bone-scaffolding materials.

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“…like a coral, algae, or trabecular bone, 19,20 which is converted to the final composition, maintaining the original structure. Joschek et al 19 studied the properties of a porous HA ceramic produced by sintering bovine bone.…”

Section: Introductionmentioning

confidence: 99%

Innovative macroporous granules of nanostructured‐hydroxyapatite agglomerates: Bioactivity and osteoblast‐like cell behaviour

Laranjeira

Fernandes

Monteiro

2010

J Biomedical Materials Res

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To modulate the biological response of implantable granules, two types of bioactive porous granules composed of nanostructured-hydroxyapatite (HA) agglomerates and microstructured-HA, respectively, were prepared using a polyurethane sponge impregnation and burnout method. The resulting granules presented a highly porous structure with interconnected porosity. Both types of granules were characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and mercury intrusion porosimetry. Results showed that nanostructed-HA granules presented higher surface area and porosity than microstructured-HA granules. In vitro testing using MG63 human osteoblast-like cells showed that on both types of surfaces cells were able to adhere, proliferate, and migrate through the macropores, and a higher growth rate was achieved on nanostructured-HA granules than on microstructured-HA granules (76 and 40%, respectively). In addition, these cells maintained similar expression levels of osteoblastic-associated markers namely collagen type I, alkaline phosphatase, bone morphogenetic protein-2, macrophage colony-stimulating factor, and osteoprotegerin. These innovative nanostructured-HA granules may be considered as promising bioceramic alternative matrixes for bone regeneration and drug release application.

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In Vitro Growth and Differentiation of Osteoblast-Like Cells on Hydroxyapatite Ceramic Granule Calcified From Red Algae

Cited by 50 publications

References 22 publications

Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics

Role of scaffold internal structure on in vivo bone formation in macroporous calcium phosphate bioceramics

Preparation and Characterization of Novel Bone Scaffolds Based on Electrospun Polycaprolactone Fibers Filled with Nanoparticles

Innovative macroporous granules of nanostructured‐hydroxyapatite agglomerates: Bioactivity and osteoblast‐like cell behaviour

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