In vitro hydrolytic degradation of poly(para-dioxanone) with high molecular weight

Bai, Wei; Chen, Dongliang; Li, Qing; Chen, Hechun; Zhang, Shenglan; Huang, Xiaochuan; Xiong, Chengdong

doi:10.1007/s10965-008-9250-y

Cited by 25 publications

(11 citation statements)

References 25 publications

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“…After 4 weeks, the cracks of PPDO/6PDO become much wider although it just appears on the surface of PPDO. The cracks appear on the surface of PPDO degradation samples have also been reported previously . As we known, PDO in PPDO/PDO mixture can leach out of the mixtures and dissolve in the solution, and it can convert to monomer acid which can catalyze the hydrolysis during the degradation process further.…”

Section: Resultssupporting

confidence: 74%

The influence of coexisted monomer on thermal, mechanical, and hydrolytic properties of poly(p‐dioxanone)

Zhou

Wen

et al. 2016

J of Applied Polymer Sci

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Poly(p‐dioxanone) (PPDO), a typical aliphatic poly(ether‐ester), is generally synthesized via ring‐opening polymerization of 1,4‐dioxan‐2‐one (p‐dioxanone, PDO) monomer. However, a quite amount of PDO monomer should coexist with PPDO product due to the characteristics of the equilibrium polymerization. To clarify the effects of PDO on the properties of PPDO, a series of PPDO/PDO mixtures with different PDO content were prepared by adding PDO to pure PPDO. The thermal, mechanical, and hydrolytic properties of PPDO and PPDO/PDO mixtures were investigated systematically. It reveals that the existence of PDO in the polymer can act as plasticizer to facilitate the crystallization of PPDO, but the increasing of PDO content deteriorates the mechanical properties of the polymers, especially when the PDO loading is more than 3 php. The PDO does not distinctly affect PPDO thermal decomposition, but obviously accelerates the PPDO hydrolytic degradation. This work may provide an important reference for the industrialization and application of PPDO. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43483.

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Section: Resultssupporting

confidence: 74%

The influence of coexisted monomer on thermal, mechanical, and hydrolytic properties of poly(p‐dioxanone)

Zhou

Wen

et al. 2016

J of Applied Polymer Sci

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“…Due to its excellent biocompatibility, biodegradation and flexibility, PDS has been investigated for use in tissue regeneration and fracture repair applications [291,292,293]. PDS when used for internal fixation of fractures has been shown to be completely biodegradable within the bone tissues [294,295]. PDS can be resorbed completely in vivo within 5–7 months via the alteration of its crystallinity, molecular weight Mw and the melting temperature [47].…”

Section: Biodegradable Materialsmentioning

confidence: 99%

Biodegradable Materials for Bone Repair and Tissue Engineering Applications

et al. 2015

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This review discusses and summarizes the recent developments and advances in the use of biodegradable materials for bone repair purposes. The choice between using degradable and non-degradable devices for orthopedic and maxillofacial applications must be carefully weighed. Traditional biodegradable devices for osteosynthesis have been successful in low or mild load bearing applications. However, continuing research and recent developments in the field of material science has resulted in development of biomaterials with improved strength and mechanical properties. For this purpose, biodegradable materials, including polymers, ceramics and magnesium alloys have attracted much attention for osteologic repair and applications. The next generation of biodegradable materials would benefit from recent knowledge gained regarding cell material interactions, with better control of interfacing between the material and the surrounding bone tissue. The next generations of biodegradable materials for bone repair and regeneration applications require better control of interfacing between the material and the surrounding bone tissue. Also, the mechanical properties and degradation/resorption profiles of these materials require further improvement to broaden their use and achieve better clinical results.

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“…Thus, establishing a method for covalent functionalization would offer a new prospective for PPDO in order to tailor its biointerface. PPDO is highly sensitive to degradation; thus, any functionalization reaction has to be performed under non‐aqueous conditions, and the polymer integrity needs to be proven after the functionalization.…”

Section: Introductionmentioning

confidence: 99%

Perfluorophenyl azide functionalization of electrospun poly(para‐dioxanone)

Luetzow

Hommes-Schattmann

Neffe

et al. 2018

Polymers for Advanced Techs

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Strategies to surface‐functionalize scaffolds by covalent binding of biologically active compounds are of fundamental interest to control the interactions between scaffolds and biomolecules or cells. Poly(para‐dioxanone) (PPDO) is a clinically established polymer that has shown potential as temporary implant, eg, for the reconstruction of the inferior vena cava, as a nonwoven fiber mesh. However, PPDO lacks suitable chemical groups for covalent functionalization. Furthermore, PPDO is highly sensitive to hydrolysis, reflected by short in vivo half‐life times and degradation during storage. Establishing a method for covalent functionalization without degradation of this hydrolyzable polymer is therefore important to enable the surface tailoring for tissue engineering applications. It was hypothesized that treatment of PPDO with an N‐hydroxysuccinimide ester group bearing perfluorophenyl azide (PFPA) under UV irradiation would allow efficient surface functionalization of the scaffold. X‐ray photoelectron spectroscopy and attenuated total reflectance Fourier‐transformed infrared spectroscopy investigation revealed the successful binding, while a gel permeation chromatography study showed that degradation did not occur under these conditions. Coupling of a rhodamine dye to the N‐hydroxysuccinimide esters on the surface of a PFPA‐functionalized scaffold via its amine linker showed a homogenous staining of the PPDO in laser confocal microscopy. The PFPA method is therefore applicable even to the surface functionalization of hydrolytically labile polymers, and it was demonstrated that PFPA chemistry may serve as a versatile tool for the (bio‐)functionalization of PPDO scaffolds.

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In vitro hydrolytic degradation of poly(para-dioxanone) with high molecular weight

Cited by 25 publications

References 25 publications

The influence of coexisted monomer on thermal, mechanical, and hydrolytic properties of poly(p‐dioxanone)

The influence of coexisted monomer on thermal, mechanical, and hydrolytic properties of poly(p‐dioxanone)

Biodegradable Materials for Bone Repair and Tissue Engineering Applications

Perfluorophenyl azide functionalization of electrospun poly(para‐dioxanone)

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