In vitro-in vivo correlation of the chiral pesticide prothioconazole after interaction with human CYP450 enzymes

Perovani, Icaro Salgado; Barbetta, Maike Felipe Santos; Silva, Rodrigo Moreira da; Lopes, Norberto Peporine; Oliveira, Anderson Rodrigo Moraes de

doi:10.1016/j.fct.2022.112947

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Exposure to organochlorine pesticides can provoke inhibition of this enzyme. For example, in vitro experiments have shown that the chiral pesticide Ethofumesate strongly inhibits CYP2C19 [ 47 ]. Another pesticide, Chlorpyrifos, can be activated as a potent β-esterase inhibitor of CYP2B6 or detoxified to dearylated metabolites by CYP2C19 [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Altynova,

Khamdiyeva,

Garshin

et al. 2023

Toxics

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The association of genetic polymorphisms with the individual sensitivity of humans to the action of pesticide pollution is being actively studied in the world. The aim of this study was a molecular epidemiological analysis of candidate polymorphisms of genes involved in pesticide metabolism, detoxification, and antioxidant protection. Some of the selected polymorphisms also relate to susceptibility to cancer and cardiovascular, respiratory, and immune system diseases in individuals exposed to pesticides for a long time. For a case-control study of a unique cohort of people exposed to organochlorine pesticides for 10 years or more were chosen, a control cohort was selected that matched with the experimental group by the main population characteristics. PCR-PRLF and genome-wide microarray genotyping (GWAS) methods were used. We identified 17 polymorphisms of xenobiotic detoxification genes and 27 polymorphisms of antioxidant defense genes, which had a significantly high statistical association with the negative impact of chronic pesticide intoxication on human health. We also found 17 polymorphisms of xenobiotic detoxification genes and 12 polymorphisms of antioxidant defense genes that have a protective effect. Data obtained added to the list of potential polymorphisms that define a group at high risk or resistant to the negative effects of pesticides.

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Section: Discussionmentioning

confidence: 99%

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Altynova,

Khamdiyeva,

Garshin

et al. 2023

Toxics

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“…However, unreasonable use may result in the residue of prothioconazole and its metabolites in agricultural products and the environment. The rapid rise of prothioconazole has aroused extensive research interest among scholars, and current research reports on prothioconazole and its metabolites mainly include toxicity assays [8,9], pathogen and toxin prevention and control [10][11][12], residue analysis method establishment [13], field efficacy [14], residue behavior in environment and crops [15,16], endocrine disruption mechanism [17], etc. Prothioconazole-desthio, the main highly toxic metabolite of prothioconazole, has higher biological activity and endocrine disrupting properties [18,19], and studies have shown that the half-life of prothioconazole-desthio in wheat plants is much longer than that of prothioconazole, with longer residual time [13].…”

Section: Introductionmentioning

confidence: 99%

Insights into the Fungicide Prothioconazole and Its Metabolite in Wheat: Residue Behavior and Risk Assessment

Fang,

Yan,

Zhang

et al. 2023

Agronomy

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To clarify the residue formation of prothioconazole and its main metabolite in wheat plants, the uptake, translocation, and metabolism of prothioconazole in wheat roots and leaves were investigated by nutrient solution culture and the spraying method. The results showed that prothioconazole and its metabolites showed a trend of increasing and then decreasing in wheat plants under two treatment methods, and the concentration of prothioconazole and its metabolites was higher in the high-concentration group (5000 μg/mL) than in the low-concentration group (1000 μg/mL). The transferability from stem to leaf was stronger than that from root to stem. In the nutrient solution culture, prothioconazole and its metabolites were mainly enriched in wheat roots. The concentration of prothioconazole in wheat roots increases with the increase in prothioconazole concentration and was significantly higher than the prothioconazole concentration on stems and leaves. In wheat leaves in the spraying method, prothioconazole and its metabolites were conducted from leaves to stems and roots up to the nutrient solution. Prothioconazole-desthio was detectable in wheat nutrient solution, while prothioconazole was not detected. Analysis of actual samples of 9 wheat grains and 28 flours showed that the residues of prothioconazole and its metabolites met the maximum residue limit (0.1 mg/mL) set in China and by the Codex Alimentarius Commission. The results will provide a theoretical basis for the scientific use of prothioconazole and food security assurance.

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Fertilization can modify the enantioselective persistence of penthiopyrad in relation to the co-influence on soil ecological health

Liu

Chen

et al. 2023

Environmental Research

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In vitro-in vivo correlation of the chiral pesticide prothioconazole after interaction with human CYP450 enzymes

Cited by 6 publications

References 24 publications

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Insights into the Fungicide Prothioconazole and Its Metabolite in Wheat: Residue Behavior and Risk Assessment

Fertilization can modify the enantioselective persistence of penthiopyrad in relation to the co-influence on soil ecological health

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