In vitro induction of the anticarcinogenic marker enzyme, quinone reductase, in human hepatoma cells by food extracts

Hashimoto, Kei; Kawamata, Shinsuke; Usui, N.; Tanaka, Ayako; Uda, Yasushi

doi:10.1016/s0304-3835(02)00018-6

Cited by 24 publications

(15 citation statements)

References 16 publications

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“…An ethyl acetate-soluble crude vegetable extract of ashitaba was shown to induce Hep G2 cell quinone reductase activity by nearly 50% in 48 h (1.42 ± 0.06-fold induction) [29]. Unfortunately, the part of the plant extracted was not specified, and chemical consituents were not determined [29]. Another study determined that NAD(P)H quinone oxidoreductase 1 (NQO1), which also protects against quinone-induced damage, was activated in murine hepatoma Hepa 1c1c7 cells by an ethanol-soluble extract of ashitaba (2.44-fold induction at 25 µg · mL −1 ).…”

Section: Chemopreventive Activitymentioning

confidence: 99%

“…Quinone reductase plays an important role in detoxification by reducing electrophilic quinones. This defends cells against quinone-induced cytotoxic effects and subsequent carcinogenesis [29]. An ethyl acetate-soluble crude vegetable extract of ashitaba was shown to induce Hep G2 cell quinone reductase activity by nearly 50% in 48 h (1.42 ± 0.06-fold induction) [29].…”

Section: Chemopreventive Activitymentioning

confidence: 99%

“…This defends cells against quinone-induced cytotoxic effects and subsequent carcinogenesis [29]. An ethyl acetate-soluble crude vegetable extract of ashitaba was shown to induce Hep G2 cell quinone reductase activity by nearly 50% in 48 h (1.42 ± 0.06-fold induction) [29]. Unfortunately, the part of the plant extracted was not specified, and chemical consituents were not determined [29].…”

Section: Chemopreventive Activitymentioning

confidence: 99%

See 2 more Smart Citations

A Review of the Medicinal Uses and Pharmacology of Ashitaba

Caesar

Cech

2016

Planta Med

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Medicinal plants are commonly employed for therapeutic purposes throughout the world. A recent National Health Interview Survey estimated that nearly 18 % of adults in the United States regularly took non-vitamin, non-mineral dietary supplements in 2012 [1]. Because of the popularity of herbal medicines, it is important to understand the chemical basis behind the purported activities of botanicals. Angelica, a member of the Apiaceae (Umbelliferae) family, is a large genus comprised of over 60 species. Members of the genus have been utilized as medicines across the world, most notably in Asia, to treat numerous ailments, including influenza, hepatitis, arthritis, indigestion, fever, and microbial infections [2]. An increasing number of studies are being conducted on a medicinally promising member of the genus, Angelica keiskei Koidzumi (Apiaceae), or ashitaba. This large leafy perennial plant native to the Pacific coast of Japan is used throughout Asia for its diuretic, laxative, stimulant, and galactagogue properties [3]. In the past decade, several active constituents representing chalcones, flavanones, and coumarins have been isolated and characterized from ashitaba, and several bioactiv-ities have been described. This review presents the current progress on ashitaba pharmacological studies, with a focus on isolated secondary metabolites, biological activity, toxicological data, and clinical relevance. Bioactive Metabolites Isolated from Ashitaba ! Chalcones Most of the literature on the bioactive metabolites from ashitaba concerns the diverse activity of various chalcones (l " Table 1 and Fig. 1), which are most abundant in the root bark of the plant [4]. Chalcones are formed from phenylpropanoid starter units, extended with three malonyl-CoA molecules. The resulting polyketide is folded by the enzyme chalcone synthase to promote Claisen condensations and subsequent enolizations [5]. Interestingly, the bioactive chalcones found in ashitaba are prenylated at the 5′-position (l " Fig. 1), indicating that these molecules have undergone multiple biosynthetic steps, travelling through the acetate, shikimate, and isoprenoid pathways.

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Section: Chemopreventive Activitymentioning

confidence: 99%

Section: Chemopreventive Activitymentioning

confidence: 99%

Section: Chemopreventive Activitymentioning

confidence: 99%

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A Review of the Medicinal Uses and Pharmacology of Ashitaba

Caesar

Cech

2016

Planta Med

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“…Several epidemiological studies have indicated that a high intake of plant products is associated with a reduced risk of a number of chronic diseases, such as atherosclerosis and cancer (Gosslau & Chen, 2004;Gundgaard, Nielsen, Olsen, & Sorensen, 2003;Hashimoto, Kawamata, Usui, Tanaka, & Uda, 2002;KrisEtherton, Etherton, Carlson, & Gardner, 2002;Law & Morris, 1998;Temple, 2000). These beneficial effects have been partly attributed to the compounds which possess antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Natural antioxidants and antioxidant capacity of Brassica vegetables: A review

Podsędek

2007

LWT - Food Science and Technology

928

632

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“…The relationship between a diet rich in vegetables and the reduction of several chronic diseases such as arteriosclerosis and cancer has been well documented in the last decade (Gundgaard, Nielsen, Olsen, & Sorensen, 2003;Hashimoto, Kawamata, Usui, Tanaka, & Uda, 2002;Kris-Etherton, Etherton, Carlson, & Gardner, 2002). In general, the beneficial effects associated with the Mediterranean diet are attributed to antioxidant compounds, such as vitamins C and E, carotenoids and phenolic compounds, especially flavonoids, abundantly present in fruits and vegetables (Podsedek, 2007).…”

Section: Introductionmentioning

confidence: 99%

Optimum controlled atmospheres minimise respiration rate and quality losses while increase phenolic compounds of baby carrots

Simões

Allende

Tudela

et al. 2011

LWT - Food Science and Technology

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a b s t r a c tBaby carrot is a very perishable product mainly due to the abrasion of the cylindrical carrot root segments. The influence of four different controlled atmospheres (CA) (air, 2 kPa O 2 þ 15 kPa CO 2 , 5 kPa O 2 þ 5 kPa CO 2 and 10 kPa O 2 þ 10 kPa CO 2 ) was studied to maintain quality and prolong the shelf life of baby carrots. Respiration rate (RR), the content of vitamin C, carotenoids and phenolics by HPLC as well as the sensory quality of baby carrots during storage at 4 C were evaluated. The lowest RR was observed in baby carrots stored under CA containing the lowest O 2 concentrations. Baby carrots under low O 2 atmospheres preserved the highest vitamin C content, as well as the individual carotenoids. The woundinduced phenolic compounds, mainly trans chlorogenic acid, increased two fold in baby carrots stored under 5 kPa O 2 þ 5 kPa CO 2 . In general, CA maintained the overall visual quality of baby carrots up to 8 days. Controlled atmosphere of 5 kPa O 2 þ 5 kPa CO 2 can be recommended as an optimum atmosphere to maintain quality of baby carrots, increasing bioactive compounds such as chlorogenic acid and avoiding anaerobic fermentation in case of temperature abuse.

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In vitro induction of the anticarcinogenic marker enzyme, quinone reductase, in human hepatoma cells by food extracts

Cited by 24 publications

References 16 publications

A Review of the Medicinal Uses and Pharmacology of Ashitaba

A Review of the Medicinal Uses and Pharmacology of Ashitaba

Natural antioxidants and antioxidant capacity of Brassica vegetables: A review

Optimum controlled atmospheres minimise respiration rate and quality losses while increase phenolic compounds of baby carrots

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