In vitro inhibition of human neutrophil elastase by oleic acid albumin formulations from derivatized cotton wound dressings

The performance of an orthosilicic acid-releasing silica gel fiber fleece in wound healing

“…Furthermore, chronic wounds often remain in the inflammatory stage for too long [32,33]. In contrast to the acute wounds' characteristic of precise balance between production and degradation of molecules such as collagen, this balance is lost and degradation plays a major role in chronic wounds [34,35]. These wounds cause patients severe emotional and physical stress and create a significant financial burden on for patients and the whole healthcare system.…”

Comparative evaluation of traditional prescriptions from Cichorium intybus L. for wound healing: Stepwise isolation of an active component by in vivo bioassay and its mode of activity

“…The metalloproteinases have degenerative effects on the structural proteins (Edwards et al, 2004). Therefore, metalloproteinase inhibitors may contribute the wound healing process.…”

Proteases and Delayed Wound Healing

“…Comparatively, human neutrophil elastase has been targeted with oleic acid/albumin formulations. 54,55 Another example of a dressing type that acts to control the microenvironment of the wound incorporates a healing accelerator, nanooligosaccharide factor, which has antiprotease properties and is released from the dressing upon contact with chronic wound fluid; this type of dressing aims to sequester the protease activity within the nonhealing wound. 56 Alternatively, Adhirajan et al 57 demonstrated the potential of modified gelatin microspheres with a catechol MMP inhibitor combined with antimicrobials incorporated into a collagen scaffold to combine the benefits of infection control and attenuation of proteases in diabetic wound tissue lysates.…”